Because knockdown of Tuba in zebrafish affects cilia in a number of organs, including the brain, a variety of aberrant phenotypes were seen in
the Tuba knockdown zebrafish model.
When grown in a collagen gel, Madin - Darby canine kidney (MDCK) cells form into cysts, and the orientation of proteins, called polarity, are abnormal following
Tuba knockdown.
Not exact matches
In zebrafish, injection of low doses of both
Tuba and Cdc42 antisense morpholinos, which had no effect when administered separately, led to severe phenotypes similar to those seen following
knockdown of other ciliary proteins.
Knockdown of dynamin - binding protein or
Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).