Sentences with phrase «tumor markers for»

Tumor markers for testicular cancer are AFP (alpha fetoprotein) and hCG (human chorionicgonadotropin).

Human papillomavirus (HPV) cfDNA in the blood is a unique tumor marker for metastatic cervical cancers.

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

Researchers targeting a small subset of tumor markers would end up paying for extra controls they didn't need.

These tumor samples consistently tied to worse outcomes in children, suggesting a critical marker for predicting prognosis.

But in May, the U.S. Food and Drug Administration for the first time allowed the use of an existing approved drug, Keytruda, to treat any solid tumor bearing a specific genetic marker.

The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»

Part of the cytoskeleton, vimentin gives flexibility and structure to the cell, but it is also a marker of epithelial - mesenchymal transition (EMT), which is considered a crucial event for metastasis in epithelial tumors.

Three of the four projects receiving CIRM money capitalize on Victoria's expertise at finding markers for differentiated stem cells versus cells that still have tumor - forming potential.

Forde said the number of gene mutations in the tumor correlated closely with response to treatment and was a potential predictive marker for future studies.

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

The enzyme «isn't just a random by - product of a tumor — it's something that can serve as a marker for growth and malignancy,» says Ester Kwon, a former postdoctoral researcher in Bhatia's lab.

Levels of a small non-coding RNA molecule called let - 7 appear to define different stages of cancer better than some of the «classical» markers for tumor progression, researchers from the University of Chicago report in the June 25, 2007, early online edition of the Proceedings of the National Academy of Sciences.

Son et al., SSEA - 1 is an enrichment marker for tumor - initiating cells in human glioblastoma.

Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy.

Yoon says the presence of these cells could be a marker for tumor growth and metastasis. Because tumors often metastasize along lymph ducts and into lymph nodes, studying this type of cells could lead to new targets for blocking tumor metastasis.

Due to these physiopathological complexity and heterogeneously, one of the major requirements for a successful therapy is the design of a multifunctional nanomedicines that is able to selectively attack specific markers from tumor and stroma cells.

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease, consensus molecular subtype, and microsatellite instability and molecular status, according to the results of an analysis (abstract 3503) of data from CALGB / SWOG 80405 presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.

However, as demonstrated by a recent report from Stuelten and colleagues [13], the complexity of CSC markers continues to pose challenges for identifying and isolating the putative tumor stem cell populations by the cell - sorting approach.

Blood Biomarkers Identified in Drug - Resistant Cancer Tumor Cells November 2016 While searching for a non-invasive way to detect prostate cancer cells circulating in blood, Duke Cancer Institute researchers have identified some blood markers associated with...

In a study involving 12 patients with bladder cancer, who also underwent prostate surgery as part of their treatment, she identified the ICOS molecule as the first immunologic marker identified in both tumor tissues and the systemic circulation that can be used as a biomarker for monitoring of anti-CTLA-4 treated patients as a possible marker of therapeutic activity.

Gb3 expression was detected independent of type (diffuse / intestinal), and was negatively correlated to increasing tumor - node - metastasis stages (P = 0.0385), as well as with markers for senescence.

DNA Detectives Find Genetic Markers for Lung Cancers Most Likely to Recur Researchers at the Johns Hopkins Kimmel Cancer Center uncovered clearly recognizable genetic alterations in tumors and tissue removed from patients with early - stage lung cancers that look like good predictors of which of these cancers are more likely to recur.

This study design will establish whether (1) DAXX can serve as a marker for early tumor growth or later advanced / metastatic PCa, and (2) high DAXX expression associates with indolent versus lethal PCa.

«PTEN is a genomic marker we already routinely measure, and based on published data we wanted to know if we could use it to predict which BRCA1 / 2 mutated tumors are likely to respond to checkpoint inhibitors and which are not,» said the study's senior author Katherine L. Nathanson, MD, deputy director of the Abramson Cancer Center and director of Genetics at the Basser Center for BRCA.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Todd, a chemist by training, was well known for his work on CEA (carcinoembryonic antigen), the best known tumor marker of its time, and his structural approach to immune problems.

In 2016, Dmitry I. Gabrilovich, M.D., Ph.D., program leader of Wistar's Translational Tumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotheTumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunothetumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

Haihui Lu, Ph.D., a CRI fellow at the Whitehead Institute for Biomedical Research, has identified a surface marker that distinguishes a population of breast cancer cells that are more prone to metastasis and demonstrate higher levels of «stemness,» the ability to seed other tumors.

Arafat and her team discovered that when they treated pancreatic tumors (developed in animals for the study) with thymoquinone, 67 % of the tumors shrunk significantly, and levels of inflammatory markers in the cells dropped substantially.

I finished chemo for TNBC a year ago, and have regular follow - up blood tests (CBC, Basic Metabolic Panel & CA15 - 3 tumor marker).

There is evidence that tumors secrete IGF - 1, which makes it a potential marker for cancer in some individuals and not necessarily a cause.

Closely monitoring several markers of cell damage (including creatine kinase, lactate dehydrogenase, prostaglandin - E and tumor necrosis factor - alpha) in their sample of 18 male athletes (who used 20 grams of creatine monohydrate per day for five days, mixed with 60 grams of maltodextrine), the researchers found levels of these markers were reduced after the race, compared to 16 control subjects who took only the maltodextrine.

These same techniques also work for other types of cancerous tumors that release these markers.

If an oncologist does a blood test for prostate cancer, he looks for a tumor marker called prostate specific antigen or PSA.