Sentences with phrase «unc phenotype»

Forward and backward movement are both affected, but the forward Unc phenotype is more severe.

The cause of the Unc phenotype is unknown but could be due to loss of functional gap junctions or to extra ectopic gap junctions established between AVA interneurons and B motor neurons, noted in EM serial sections of an unc - 7 (e5) animal (White et al., personal communication, originally cited in [9]; Figure 1).

Eight animals displayed a severe backward Unc phenotype but were still capable of forward locomotion, confirming that AVAs had been properly ablated.

Therefore, part of the characterization of the Unc - 7 phenotype involves understanding how ectopic gap junction channels arise in the absence of the UNC - 7 innexin, and whether or not these ectopic neuronal connections contribute to the Unc phenotype.

Not exact matches

Broods from these animals grown at 15 °C were later examined for the presence of any animals displaying a kinker (Unc -124-like) phenotype.

If ectopic gap junctions are the sole cause of the Unc - 7 phenotype, then laser ablation of AVAs should eliminate communication between these interneurons and the B motor neurons and restore normal forward locomotion; in conjunction with AVA ablation, animals should be backward Unc (Figure 1).

The phenotype of unc - 9 unc - 7 double mutants is no more severe than either single mutant phenotype, consistent with the co-localization of UNC - 9:: GFP and UNC - 7S.

The focus of action of the e1500 rubberband phenotype is the body wall muscles — when the sup - 10 (+) free duplication mnDp3 is present in body wall muscles, the animals have a rubberband phenotype due to unc - 93.

The AVA interneurons in ten unc - 7 (e5) L1 animals were then targeted; none displayed improvement in forward locomotion, supporting the conclusion that ectopic AVA: B gap junctions are not the sole cause of the Unc - 7 phenotyunc - 7 (e5) L1 animals were then targeted; none displayed improvement in forward locomotion, supporting the conclusion that ectopic AVA: B gap junctions are not the sole cause of the Unc - 7 phenotyUnc - 7 phenotype.

The phenotype of unc - 9 daf - 6 unc - 7 mutants was no more severe than unc - 7 alone, consistent with UNC - 7 and UNC - 9 acting in the same process.

Since unc - 7 encodes a gap junction protein, we presumed that the mutant Unc - 7 uncoordinated phenotype reflects a loss of functional gap junction channeunc - 7 encodes a gap junction protein, we presumed that the mutant Unc - 7 uncoordinated phenotype reflects a loss of functional gap junction channeUnc - 7 uncoordinated phenotype reflects a loss of functional gap junction channels.

Although the focus of action of unc - 9 can not be precisely determined from these mosaic experiments, the results are consistent with the interpretation that loss of unc - 9 (+) function from the P1 lineage can be tolerated without apparent effects on locomotion, and that the loss of unc - 9 (+) function from within the AB lineage gives rise to the Unc - 9 phenotyunc - 9 can not be precisely determined from these mosaic experiments, the results are consistent with the interpretation that loss of unc - 9 (+) function from the P1 lineage can be tolerated without apparent effects on locomotion, and that the loss of unc - 9 (+) function from within the AB lineage gives rise to the Unc - 9 phenotyunc - 9 (+) function from the P1 lineage can be tolerated without apparent effects on locomotion, and that the loss of unc - 9 (+) function from within the AB lineage gives rise to the Unc - 9 phenotyunc - 9 (+) function from within the AB lineage gives rise to the Unc - 9 phenotyUnc - 9 phenotype.

unc - 93 (e1500) confers a gain - of - function rubberband phenotype that is suppressed by the recessive sup - 10 (mn219) mutation.