Use of nanoparticles in many applications, e.g. for catalysis, relies on the surface area of the particles.
Not exact matches
Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class
of therapies to target and selectively destroy cancer cells
using viral
nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011
in ocular melanoma (OM).
Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class
of therapies to target and selectively destroy cancer cells
using viral
nanoparticle conjugates, announced today that it has enrolled and dosed the first patient
in its Phase 1b clinical trial
of light - activated AU - 011, an investigational, first -
in - class targeted therapy
in development for the treatment
of ocular melanoma, a rare and life - threatening disease.
Metal oxides such as zinc oxide and titanium dioxide are increasingly being
used in sunscreens and cosmetics
in the form
of nanoparticles — microscopic particles
of matter measured on the nanoscale.
Antimicrobials such as
nanoparticles of silver or titanium dioxide can be
used in packaging to prevent spoilage
of foods.
The researchers
used an ultrastable, variable - temperature stage
in an aberration - corrected scanning transmission electron microscope to subject an array
of size - selected gold
nanoparticles (or clusters) to temperatures as high as 500 °C while imaging them with atomic resolution.
«We envision that these photo - responsive polymer - capped gold
nanoparticles could one day serve as nano - carriers for drug delivery into the body
using our robust and reversible process for assembly and disassembly,» said Zhiqun Lin, a professor
in the Georgia Tech School
of Materials Science and Engineering.
«We envision that our
nanoparticle therapy could be
used to speed the healing
of all sorts
of wounds, including everyday cuts and burns, surgical incisions, and chronic skin ulcers, which are a particular problem
in the elderly and people with diabetes,» said study co-leader David J. Sharp, Ph.D., professor
of physiology & biophysics at Einstein.
As a proof
of concept for this study, the researchers tested the plant virus - derived
nanoparticles with a nematicide called crystal violet, which has been
used to kill nematodes on skin but not
in agriculture.
This clinical study, published
in the Proceedings
of the National Academy
of Sciences, tested the possibility
of imaging inflammation
in the pancreas
of human volunteers
using ferumoxytol, a coated iron
nanoparticle approved by the FDA as an iron replacement therapy, and MRI.
«We
use biological
nanoparticles — a plant virus — to deliver a pesticide,» said Paul Chariou, a PhD student
in biomedical engineering at Case Western Reserve and author
of a study on the process published
in the journal ACS Nano.
«
Use of the
nanoparticle increases soil diffusion while decreasing the risk
of leaching and runoff, reducing the amount
of chemical
in food crops and reducing the cost to treat crops.»
In a paper published in the current online issue of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting,» the researchers report the use of a novel biodegradable and photoluminescent poly (lactic acid) nanoparticle, loaded with melanoma - specific drugs with immune cells as the nanoparticle carrier
In a paper published
in the current online issue of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting,» the researchers report the use of a novel biodegradable and photoluminescent poly (lactic acid) nanoparticle, loaded with melanoma - specific drugs with immune cells as the nanoparticle carrier
in the current online issue
of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic
Nanoparticles for Melanoma Targeting,» the researchers report the
use of a novel biodegradable and photoluminescent poly (lactic acid)
nanoparticle, loaded with melanoma - specific drugs with immune cells as the
nanoparticle carriers.
They
use a near - infrared laser beam, which can penetrate deep —
in this context, deep means a centimeter or two — into the tissue, where a
nanoparticle turns the near - infrared light into blue light, and that directs the activity
of genetically engineered immune cells.
Their research, published online Sunday
in Nature Nanotechnology, involved the
use of cobalt oxide
nanoparticles to split water into hydrogen and oxygen.
Scientists at the University
of Florida Particle Engineering Research Center and personal products manufacturer Kimberly - Clark recently found an answer by coating silica
nanoparticles with copper ions, a potent odor - fighting combination that could be
used in powders and spritzes, mixed with cat litter, or embedded
in products like garbage bags.
So did
using much larger particles
of cobalt - chromium
in place
of the
nanoparticles.
Magnetotactic bacteria can even sense the earth's magnetic field by making
use of magnetic
nanoparticles in their interior that act as an internal compass.
The technique can be applied
in myriad ways, some
of which include droplet - based microreactors (devices
used in chemical synthesis),
nanoparticle synthesis, tissue engineering, drug discovery and drug delivery monitoring.
In earlier work, Demir Akin
of Stanford University and his colleagues
used antibodies and
nanoparticles to attach molecules
of DNA to weakened Listeria monocytogenes, which is a bacterium responsible for many cases
of food poisoning.
To create a new dengue virus vaccine, Stefan Metz, Shaomin Tian
in the laboratories
of Aravinda de Silva, Chris Luft and Joe DeSimone at the University
of Carolina, Chapel Hill, USA designed
nanoparticles of various shapes and sizes
using Particle Replication
in Non-wetting Template (PRINT) technology.
The
nanoparticles were 30 - nanometre - wide beads
of surgical cobalt - chromium alloy, a material
used in much larger pieces to make surgical implants such as hip prostheses.
Wilson, the sporting goods manufacturer, has nanoengineered layers
of clay to double the playing life
of its Double Core tennis balls; L'Oréal
uses nanoscale particles and capsules
in their cosmetic creams that allow replenishing ingredients to penetrate deep into the skin; and the Australian company Advanced Powder Technology has created Zinclear, a translucent zinc oxide sunblock composed
of nanoparticles as small as the tiniest known viruses.
A technique
using anesthesia - containing
nanoparticles — drawn to the targeted area
of the body by magnets — could one day provide a useful alternative to nerve block for local anesthesia
in patients, suggests an experimental study
in the April issue
of Anesthesia & Analgesia, official journal
of the International Anesthesia Research Society (IARS).
To demonstrate one potential
use of the
nanoparticles, the research team
used them as advanced catalysts for ammonia oxidation, which is a key step
in the production
of nitric acid (a liquid acid that is
used in the production
of ammonium nitrate for fertilizers, making plastics, and
in the manufacturing
of dyes).
The second visualization was a movie captured at 23,000 - times magnification that revealed the movements
of a group
of nanoparticles reacting to an electron beam, which mimics the effects
of the infrared radiation
used in cancer therapies.
In general, catalysts are rare metals (platinum, for example), which are often used in the form of nanoparticle
In general, catalysts are rare metals (platinum, for example), which are often
used in the form of nanoparticle
in the form
of nanoparticles.
Now, Johns Hopkins researchers report they have
used nanoparticles to successfully deliver a new therapy to glioma cells
in the brains
of rats, prolonging their lives.
Fiering is testing the
use of heat
in combination with
nanoparticles.
Researchers have begun to focus on the environmental and health consequences
of nanoparticles, tiny shreds
of elements
used in a range
of commercial products.
When Gao joined Koo's lab
in 2013, he proposed
using these
nanoparticles in an oral setting, as the oxidation
of hydrogen peroxide produces free radicals that can kill bacteria.
They also showed that the
nanoparticles» reaction with a 1 percent or less hydrogen peroxide solution was remarkably effective at killing bacteria, wiping out more than 99.9 percent
of the S. mutans
in the biofilm within five minutes, an efficacy more than 5,000 times greater than
using hydrogen peroxide alone.
«We then evaluated the system
in rats with glioma and found that by
using a method called intracranial convection - enhanced delivery, our
nanoparticles could penetrate completely throughout the tumor following a single injection,» says Jordan Green, Ph.D, associate professor
of biomedical engineering and ophthalmology at Johns Hopkins.
To demonstrate the potential for treating lung disease, the researchers
used the
nanoparticles to block two genes that have been implicated
in lung cancer — VEGF receptor 1 and Dll4, which promote the growth
of blood vessels that feed tumors.
Scientists at the U.S. Naval Research Laboratory (NRL) Materials Science and Technology Division have developed a novel one - step process
using, for the first time
in these types
of syntheses, potassium superoxide (KO2) to rapidly form oxide
nanoparticles from simple salt solutions
in water.
His research group will also work on targeted delivery
of the drug
using their patent pending «nanobowls,» which are magnetically guided
nanoparticles that can be packed with drugs and diagnostic molecules, deliver them to particular sites
in the body and release them on demand.
To
use this motion - sensing technique
in a practical device, Aksyuk and Roxworthy embedded the gold
nanoparticle in a microscopic - scale mechanical structure — a vibrating cantilever, sort
of a miniature diving board — that was a few micrometers long, made
of silicon nitride.
Furthermore, the researchers from Aalto University and University
of Jyväskylä have recently shown how DNA origamis can be
used in efficient fabrication
of custom - shaped metal
nanoparticles that could be
used in various fields
of material sciences.
And secondly, this 2D exciton is stable at room temperature and robust against defects, as it is present
in any type
of TiO2 — single crystals, thin films, and even
nanoparticles used in devices.
Anikeeva, who is now at the Massachusetts Institute
of Technology (MIT)
in Cambridge, decided to see if she could
use magnetic
nanoparticles to go deeper.
To achieve gene editing
in mice with thalassemia, professor
of therapeutic radiology and
of genetics Peter M. Glazer, M.D. and his co-authors developed an alternative approach
using a novel combination
of nanoparticles, synthetic pieces
of DNA, and a simple IV injection.
Using transmission electron microscopy imaging and powder X-ray diffraction to study the structural characteristics
of the
nanoparticles and Raman and photoluminescence spectroscopies to quantify lattice strain and photoluminescence behavior, the group found a correlation between the amount
of tin
in the core and how well the core's lattice matched that
of the cadmium - sulfide outer shell.
To date, the method
used to integrate upconversion
nanoparticles into glass has relied on the
in - situ growth
of the
nanoparticles within the glass.
Using DNA strands just 58 nucleotides long to uniquely identify each particle allows researchers to skip the cell culture screening altogether — and test a hundred or more different types
of nanoparticles simultaneously
in just a handful
of animals.
«
Using the DNA barcoding technique, which we call Joint Rapid DNA Analysis
of Nanoparticles (JORDAN), we are able to do the testing
in just three animals.»
Daniel Getts, chief scientific officer
of Cour Pharma
in Chicago, Illinois, says he has written WHO to suggest the
use of his company's Immune Modifying
Nanoparticles, designed to reduce tissue damage by binding immune cells called monocytes.
So far, Roukes has
used this system to measure the masses
of gold
nanoparticles and three proteins found
in the blood serum
of cows.
Joel Friedman, a professor at the Albert Einstein College
of Medicine; Adam Friedman, the chief dermatology resident at Albert Einstein Medical Center; and Kelvin Davies, an associate professor
of urology, have demonstrated that
nanoparticles can be
used to deliver erection drugs
in the form
of a topical cream.
But that is precisely what Yuebing Zheng, assistant professor
of mechanical engineering at The University
of Texas at Austin, is working toward with his «nanotweezers» — a new tool for handling
nanoparticles using light that could create opportunities for innovations
in nanotechnology and individual health monitoring.
Wang's research group designed a five - metal catalyst based on these high - entropy - alloy
nanoparticles and demonstrated superior catalytic performance for selective oxidation
of ammonia to nitrogen oxide, a reaction
used by the chemical industry to produce nitric acid, an important chemical
in the large - scale production
of fertilizers and other products.