Using genetic markers to identify individual dogs» potential for illness; experiences of former chief vet of Los Angeles; why cats are underserved, undervalued as pets
The process was developed
using genetic markers from American Kennel Club (AKC) breeds and some non-AKC breeds in the U.S., as well as purebred dogs from the United Kingdom, Australia, and Europe.
Until recently the process of mapping the spread has been carried out
using genetic markers, a kind of bacterial «fingerprint.»
«One of the ways we can reduce the amount of time is by
using genetic markers to evaluate which genes are of interest to us.»
«
Using genetic markers, people have been able to go far back and show that there were retroviral infections that were responsible for the creation of the placenta in mammals,» says Moore.
«We envision
using these genetic markers to help doctors decide which treatments would work best to keep patients healthy.»
Using genetic markers, the researchers found that 55 subjects had received the chromosome from their mother and 25 from their father.
Using genetic markers, the scientists showed that within the same colony, bees from one lineage started fanning at a slightly different temperature than did bees from a different lineage.
Alcino Silva, distinguished professor of psychology at UCLA, has been
using genetic markers and a highly miniaturized microscope to zero in on sets of brain cells in mice with such interconnected or «linked» memories.
Australian team
uses genetic markers to identify the most viable embryos to eliminate risk of multiple pregnancies
Linkage studies
use genetic markers, which act like signposts, pointing researchers to the general area on the chromosome where genes associated with certain traits likely reside.
«It is still highly contentious whether we can
use genetic markers to predict athletic performance,» she says.
Seed producers can now
use the genetic marker for the Shell gene to distinguish the three fruit forms in the nursery long before they are field - planted.
A couple of years ago
we used genetic markers to prove that in one case the baby's leukaemia was indeed maternal in origin.
Success to date has been hampered by
using genetic marker arrays designed for within - breed genetic mapping [8] in an across - breed mapping context.
Not exact matches
The
use of
genetic engineering, instead of
marker assisted selection, in the development of Golden Rice is being criticized.
But in May, the U.S. Food and Drug Administration for the first time allowed the
use of an existing approved drug, Keytruda, to treat any solid tumor bearing a specific
genetic marker.
The lab has also shifted from testing
genetic markers known as short tandem repeats (STRs), which are standard in paternity testing, to recording single letter variants in the
genetic code known as single nucleotide polymorphisms, or SNPs, which are rarely
used for this purpose.
By identifying the gene,
genetic markers can now be
used in breeding programs to ensure that salt tolerance can be maintained in future cultivars of soybean that will be grown in areas prone to soil salinity.
Then they powdered single teeth from 36 skeletons ranging in age from 3300 years to 1500 years old and extracted tiny fragments of mitochondrial DNA (mtDNA), a
marker commonly
used for
genetic typing of human populations.
A chromosome - specific BAC library was
used to assemble 82 % of the chromosome into 1036 contigs that were anchored with 1443 molecular
markers, providing a major resource for
genetic and genomic studies.
Funded by the National Zoological Gardens of South Africa, Rufford's Small Grants for Nature, and the National Geographic Society, Parusnath is developing and testing microsatellite
markers similar to those
used in human parentage tests to establish the
genetic relatedness of Sungazers in different populations across the species» distribution.
To demonstrate the utility of the gorilla Y chromosome sequence they generated, the researchers designed
genetic markers that can be
used to differentiate the
genetic relatedness among male gorillas and thus to aid in conservation genetics efforts targeted at preserving this endangered species.
«This discovery has allowed us to develop
genetic markers that are being
used to breed more salt - tolerant grapevine rootstocks, allowing new genotypes to be screened at the seedling stage rather than through lengthy and expensive field - based vineyard trials.»
Molecular
markers — pieces of DNA that «mark» a specific gene — allow researchers to comb the
genetic blueprint of a plant, match the sequence with a certain trait
using computer programs, and develop seeds.
This study also increased the number of
genetic markers scientist can
use to study the population biology of great white and related sharks, Stanhope said, by a thousandfold, from which they hope to further expand knowledge of these fascinating animals, many of which are in urgent need of conservation.
After extracting tiny amounts of ancient DNA from the mummies» bones, the researchers amplified 16 short tandem repeats (short sequences in the DNA that create a
genetic fingerprint) and eight polymorphic microsatellites (hereditary molecular
markers) to testable quantities
using techniques commonly employed in criminal or paternity investigations.
They were mapping
genetic markers that could be
used to determine where illegally traded chimps came from so they could be returned to their homes in the wild.
The
genetic variations that the researchers have studied do not affect the oxytocin receptor itself: they are
markers used for practical reasons.
Where previous methods
used just 10 to 20 genes to create an evolutionary history, Faircloth's approach creates a more complete and accurate picture by
using more than 1,000
genetic markers.
Single nucleotide polymorphisms (SNPs,
used as
genetic markers in DNA profiling) can produce single amino acid polymorphisms (SAPs) in the amino acids that make up protein.
With the advent of more and more sophisticated ways to measure
genetic variation and relatedness
using molecular
markers, such as allozyme polymorphisms and DNA - based
markers, not only can individuals be tracked as to their parentage, but changes in allele patterns over time and thus the effects of evolution on populations can be «seen» in the
genetic information.
«In the space of just five years, reasonably affordable studies
using DNA sequencing have advanced from
using only a handful of
genetic markers to more than 2,000 — an unbelievable amount of DNA,» adds Simison.
This time, to check my
genetic fortitude against such toxins I will
use data from more than 1.5 million DNA
markers I had tested for this project.
In one study, researchers at deCODE Genetics Inc., in Reykjavik, Iceland,
used 300,000
genetic markers to scan the DNA of 1607 Icelanders who had had heart attacks, along with DNA from 6728 healthy controls.
«Stepparent - stepchild relationships in particular have neither legal nor
genetic ties, which are the two
markers that legally and culturally we
use to decide who is obligated to whom,» Ganong said.
But Thorsby was able to
use blood samples from the islanders, collected since the 1970s, to examine their DNA for particular
genetic markers.
Here, we
used parentage analysis with multilocus microsatellite
markers to measure how varying levels of
genetic introgression with non-native rainbow trout (Oncorhynchus mykiss) affect reproductive success (number of offspring per adult) of native westslope cutthroat trout (Oncorhynchus clarkii lewisi) in the wild.
Biologists typically look for
genetic connections by
using genome - wide association studies, which statistically associate
genetic markers with disease.
Objective To identify common
genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular
use of aspirin and / or NSAIDs and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.
Hence, understanding the interrelationship between
genetic markers and
use of aspirin and NSAIDs, also known as gene × environment interactions, can help to identify population subgroups defined by
genetic background that may preferentially benefit from chemopreventive
use of these agents and offer novel insights into underlying mechanisms of carcinogenesis.
Previous
genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common
genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular
use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.
This means that the materials are usually non-adapted (exotic or semi-exotic), but their desirable traits can be
used in crosses,
genetic studies, molecular
marker development and parent - building.
Similar issues could arise from the ability to identify people at a higher risk for contracting or spreading a disease
using human
genetic markers.
The booklet discusses in detail and in simple language agricultural biotechnology as it compares with conventional breeding, the agricultural biotechnology tools
used in crops such as tissue culture and micropropagation, molecular breeding and
marker - assisted selection, and
genetic engineering and GM crops.
Genetic markers of infectivity or likelihood of being a super-spreader could be
used to justify quarantine and isolation policies, with the concomitant implications for individual liberty.
In collaboration with data - sharing networks, namely MalariaGEN and STOP - HCV, they are
using genetics as a tool to investigate the underlying biology of infectious diseases and to identify
genetic markers that correlate with clinical outcomes.
Following this insight, the first
genetic maps that allowed researchers to trace patterns of inheritance in humans were made
using as
genetic markers locations on chromosomes where restriction enzymes slice through the DNA.
Botstein and Davis led an effort that resulted in an idea that at the time was absolutely radical, namely, that you don't have to map the observable traits, known as phenotypes, but instead can follow inheritance patterns
using random differences in DNA as
genetic markers — differences neutral to evolution and that have nothing to do with observable traits.
Some gene - editing techniques, while effective at modifying the
genetic code, involve the
use of
genetic markers that then leave a «scar» on the newly edited genome.