Using human colon cancer cells and primary human fibroblasts isolated from tumors and adjacent normal tissues, Alexandros Glentis and colleagues at the Institut Curie addressed the question of whether the cancer cells or the CAF cells were responsible for the breakdown of the basement membrane that leads to cancer progression.
While cautioning that the new radiation delivery system is still far from ready for
use in people, Abraham notes that P32 gives off high energy that can penetrate through 5 millimeters of
human tissue, making it a good candidate to tackle
colon cancer since
colon cancer cells can often form large, thick tumors into which drugs may not penetrate very well.