Sentences with phrase «using laboratory models»

Using budding yeast Saccharomyces cerevisae, a frequently used laboratory model in aging research, Stowers scientists experimentally used heat and other forms of stress to induce misfolded proteins to clump together.

Using a laboratory model made from post-surgery cervical and colo - rectal human tissue, researchers at the University of Pittsburgh Graduate School of Public Health are seeing positive initial results in HIV prevention by adding powerful antibodies to a topical gel.

Not exact matches

Liboiron uses her position as the head of the Civic Laboratory for Environmental Action Research to advocate for open science hardware and lead «a small but growing movement for people who make technology and instruments open source,» something she describes as «very much against the model that runs many universities around the world.»

The machine - learning - based model by Medial EarlySign used data found in EHRs, such as laboratory tests results, demographics, medication, and diagnostic codes, to predict a patient's risk of experiencing renal dysfunction.

The extreme cases of unambiguous wave and particle behaviour occur in mutually exclusive laboratory situations.7 As one physicist puts it, you may have to use a wave model on Mondays, Wednesdays and Fridays, and a particle model on Tuesdays, Thursdays, and Saturdays.

First there are experimental models which can actually be constructed and used in the laboratory.

The reliability and stability of these methods were described by Wu et al. 27 Illumina tag sequencing of the 16S rRNA gene V4 - V5 hypervariable region was performed at the Marine Biological Laboratory in Woods Hole, Massachusetts, using established methods.28, 29 Details of sequencing methods, quality control and filtering, and statistical modeling are presented in the eAppendix in the Supplement.

Using these cells, the team modeled the patients» neurons and blood - brain barrier in a laboratory dish.

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

Using geological observation, laboratory impact experiments and computer modeling, Schultz and Brown graduate student Stephanie Quintana have offered a new explanation for how those streaks were formed.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

The ability of the inorganic component of sea spray particles to take up water has been the focus of this international study where a large suite of well - controlled laboratory experiments have shown, for the first time, that the hygroscopicity of the inorganic component of sea spray is significantly lower than pure sodium chloride, a substance routinely used to describe their hygroscopicity in climate models.

We were very surprised based on the fact that previous models people used for planet formation suggested a much higher critical shock pressure,» says Richard Kraus, now a scientist at Lawrence Livermore National Laboratory and lead author on the paper published in March in Nature Geoscience.

The model has already been integrated into the next generation of the global land model used for climate simulations by the NOAA Geophysical Fluid Dynamics Laboratory, a major national climate modeling center.

As it matures, the authors wrote, it is moving «from laboratory - based experimental studies in model systems to a mature discipline that is yielding products that are being evaluated and used in the clinical domain.

«The problem is that most of the plant - tolerance models we currently use to predict these outcomes are based on laboratory studies or plant physiological studies, so they often don't factor in the compounding effects of simultaneous stressors like drought and pressure from natural enemies.

«For the onboard measurements to be meaningful, we needed to develop a model that predicted the arrival times using ground - based observations provided by our collaborators at radio telescopes around the world,» said Paul Ray, a SEXTANT co-investigator with the U. S. Naval Research Laboratory.

So far Reed has established a proof of concept in Drosophila fruit flies, a commonly used model species in laboratories across the world.

Gerber co-directs UVA's Predictive Technology Laboratory, which uses data to create predictive models with the goal of promoting better decision making.

Working in Morrison's Neurotrauma and Repair Laboratory at Columbia Engineering, the team developed a blast injury model using a shock tube and custom - designed sample receiver to simulate a primary blast event and applied it to an isolated, living model of the BBB that consisted of brain endothelial cells.

The model has been validated through laboratory experiments on a human - made freak or rogue wave (the so - called «soliton splash») using test tanks.

The researchers also plan to continue collaborating with the Pacific Northwest National Laboratory to continue vetting their atmospheric model using cloud chamber simulations and controls.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

Working at the Linac Coherent Light Source (LCLS) X-ray laser at the Department of Energy's (DOE's) SLAC National Accelerator Laboratory, the scientists then used a newly designed injection system, engineered by a team from Arizona State University, to stream the gel into the path of the X-ray pulses, which hit the crystals and produced patterns used to reconstruct a high - resolution, 3 - D model of the receptor.

In the study, Lauren Lowman, a doctoral student in Barros's laboratory, used a hydrological computer model to simulate the ecological impacts of tropical cyclones from 2004 - 2007.

«This study, carried out using laboratory rats modeling stroke, demonstrated that ischemic stroke — in both its subacute and chronic stages — damages the BSCB in a variety of ways, creating a toxic environment in the spinal cord that can lead to further disability and exacerbate disease pathology,» said study lead author Dr. Svitlana Garbuzova - Davis, associate professor in USF's Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair.

So Morton has spent a good chunk of her time at Colby developing a laboratory curriculum that involves starting students off with directed experiments (i.e., with explicit instructions and clear procedures) before giving them the chance — using the directed experiments as models — to design their own experiments.

In laboratory studies, the researchers conducted a series of experiments involving 3,5 di - tert - butylcatechol, or DTBC, a compound that is used as a model substance for tracking the chemistry of oxidation.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

A team led by Charles R. Carrigan at Lawrence Livermore National Laboratory (LLNL) used field experiments to build a new, complex model that predicts isotopic ratios of noble gases that would be released from such explosions (Sci.

A team of researchers from the Hyperbaric Biomedical Research Laboratory at the University of South Florida (USF) doubled survival time in an aggressive metastatic cancer model using a novel combination of non-toxic dietary and hyperbaric oxygen therapies.

The protein was manufactured synthetically for the first time in a laboratory in Vienna 25 years ago and since then has been used worldwide as an allergen model in research.

Yet that's just what researchers have done, using a seemingly simple laboratory model of rifting on the seafloor.

When projects on the scale of a nuclear power station or THORP are concerned, or the release of genetically modified organisms into the environment, to give another example, it is not possible to model them fully in the laboratory using traditional trial - and - error methodology.

The researchers developed algorithms to use in a «systems biology modeling cycle,» in which they repeatedly fit a model to gene expression data obtained from laboratory experiments until a good fit was obtained between the predicted and the measured outcomes.

The scientists are able to use tissue not only from laboratory mouse models, but also from human patients.

The researchers demonstrated the efficiency of the chip laboratory using a model system of gene regulation, the Lac - Operon.

One type of efflux pump, which until recently had only been studied in parts, was recently modeled in its entirety and simulated using supercomputers at Los Alamos National Laboratory.

Such ease of use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workshouse will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workshouse of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workshoUse (which organized the workshop).

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

«If you compare the fuel we use with the devices we have, we're very limited,» says Leonard Tender, an electrochemist at the Naval Research Laboratory in Washington, D.C. «We can look at how microbes do it and use them as a model.»

For assessing the global ocean - carbon sink, McKinley and her co-authors from the National Oceanic and Atmospheric Administration (NOAA) Pacific Marine Environmental Laboratory, NCAR and the University of Colorado Boulder used the model to establish a long - running climate scenario from historical data.

This arrangement, which was modeled using Argonne National Laboratory's Mira supercomputer, gives rise to spirals that twist in opposite directions, a structure not seen in any natural protein.

Using large - scale numerical modeling as well as GPS velocities from the largest GPS data - processing center in the world — the Nevada Geodetic Laboratory at the University of Nevada, Reno — Kreemer and Gordon have showed that cooling of the lithosphere, the outermost layer of Earth, makes some sections of the Pacific plate contract horizontally at faster rates than other sections.

In order to guarantee the compatibility of these tests on a global scale, the laboratories use model species specified by international guidelines, including a species of earthworm.

Combining chemotherapy and birinapant significantly improved disease - free survival in laboratory models of human ovarian cancer compared to using either therapy alone.

Using laboratory mouse models of inflammatory and neuropathic pain, they showed that the antibody can target the Nav1.7 channel and reduce the pain sensation in these mice.

Using both computer modeling and laboratory experiments, they discovered that it was possible to enhance the production of individual components of the cell wall under certain stress conditions by regulating different transcription factors.

With mathematical modelling and sociodemographic data alongside the laboratory values, the scientists used a multidisciplinary approach to elucidate the speed of virus spread, areas most affected by Zika and the link to malformations in newborns.