Using lymphoid tissue infected with HIV, the scientists compared cell death rates between cell - to - cell and cell - free virus transfer.
Not exact matches
Through the
use of powerful genomic techniques, researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) have found that the development of immune cells, called innate
lymphoid cells (ILCs), gradually prepares these cells for rapid response to infection.
Using mice bred to lack some types of
lymphoid cells, among other features, researchers were able to show that those mice still had high levels of suPAR and proteinuria, indicating that
lymphoid cells were not the perpetrators of kidney disease.
Tissue - cultured corneal cells were
used for in vitro studies rather than the usual
lymphoid cells since corneal cells are the relevant target cells in vivo during corneal allograft rejection.
Finally, the HZI will help develop in vivo imaging technologies to characterize (i) vaccine biodistribution and persistence, and (ii) cellular and molecular changes at the injection site and in draining
lymphoid tissues, helping to refine the
use of animal models.
Complete phenotyping of the mouse immune system by polychromatic and mass cytometry (CYTOF), thanks to a set of standardised protocols enabling isolation of viable cells from
lymphoid and non-
lymphoid organs (lung, skin, intestine,...) for labelling
using complex ranges of antibodies whose compatibility allows the simultaneous registration of 50 quantitative parameters at least (size, structure, specific antibodies and cell viability).
The scientists say the latest findings, published in the journal Cell Host & Microbe, should spark greater
use of
lymphoid tissue T cells to study the pathogenic effects of HIV.
Mediastinal: The mediastinum is a term
used for a special aggregation of
lymphoid tissue in the chest.
The mediastinum is a term
used for a special aggregation of
lymphoid tissue in the chest.