Sentences with phrase «using rodent models»

Using rodent models of opiate addiction, Dr. Laviolette's research has shown that opiates affect pathways of associative memory formation in multiple ways, both at the level of anatomy (connections between neurons) and at the molecular levels (how molecules inside the brain affect these connections).

In the current study, researchers at the University of North Carolina at Chapel Hill and Stanford University used rodent models to examine the role of this neurotransmitter in dynamically tracking specific elements of value - based decision making.

It only infects primates so researchers can't use rodent models to study the disease.

To help understand the development of ALD, this study used a rodent model to examine differences in liver damage between binge drinkers and heavy drinkers.

Using a rodent model of opiate addiction, Laviolette's team found that the process of opiate addiction and withdrawal triggered a switch between two molecular pathways in the amygdala controlling how opiate addiction memories were formed.

In the new study, the researchers used rodent models to compare this kind of «biased» KOR agonist, called triazole 1.1, and a conventional KOR agonist.

Currently, the human health risk from exposure to a given endocrine disruptor is normally assessed using a rodent model.

Researchers using a rodent model of childhood manganese exposure have found that too much manganese early in development causes lasting attention deficits and other impairments.

Diet - Induced Metabolic Syndrome in Rodent Models - An article from the March 2007 issue of Animal Lab News on how diets made from purified ingredients influence the phenotypes of the MS in commonly used rodent models, authored by our scientists.

(3) In this brief review, we discuss how diets made from purified ingredients influence the phenotypes of the MS in commonly used rodent models.

A discussion of how diets made from purified ingredients influence the phenotypes of the MS in commonly used rodent models.

Rodent Models: Interventional IER trials in animal populations have exclusively used rodent models.

Using a rodent model, Eftestøl et al. (2016) compared the effects of the same number of electrically - stimulated contractions (using the same magnitude of electrical stimulus) with either a high external load (isometric contraction) or a low external load (high - velocity contraction).

Not exact matches

Using gene editing to create rodents that are ideal research models could narrow the genetic divide between humans and their animal stand - ins.

The study used a proven rodent model of HO that mimics the injuries seen in combat casualties.

Both manuscripts detail the role of the same AP2 - G transcriptional regulator with remarkably similar findings — despite the different groups» having worked with two highly diverged malaria parasites: Plasmodium falciparum, which causes the most severe form of human malaria and Plasmodium berghei, a commonly used model parasite infecting rodents.

Meanwhile the anaesthetist can concentrate on her research interests, on the effect of CO2 on the regulation of circulation by the heart, using the isolated heart model of wildtype and transgenic rodent.

A lot of the work that we do relies on the use of rodents, animal models, rats and mice in particular.

For the JCI study, the team applied the radiotracer to monitor olfactory sensory neuron population dynamics in a rodent model, using PET to measure its uptake across the animals» lifespan, including during age - related neurodegeneration.

In the new study, Dr. Greenamyre and his team — led by coauthors Roberto Di Maio, Ph.D., and Paul Barrett, Ph.D., both of PIND — used a well - established rodent model of PD to show exactly how alpha - synuclein disrupts mitochondrial function.

During panel discussions Sept. 18 at 6, 7 and 8 a.m. PDT (9, 10 and 11 a.m. EDT), scientists and researchers will discuss the various science and research studies, including RapidScat, 3 - D printing in Zero - G, technology to measure bone density, and model organism research using rodents, fruit flies and plants.

NASA will host a prelaunch panel discussion at 8 a.m. PDT Sept. 18, at the agency's Kennedy Space Center in Florida, featuring scientists and researchers who will discuss various science and research studies, including the four Ames - supported payloads to study model organism research using yeast, rodents, fruit flies and plants.

Pandey performed the experiments using an animal model during which rodents were exposed to alcohol for a long period of time.

Emory's Donald (Tig) Rainnie and his research team use freely moving rodent models to examine the effects of DBS on neural circuits thought to be disrupted in depression.

- Modelling Human Disease in Rodents with CRISPR / Cas9 Genome Editing: June 27th - Why do the results discovered using genetically engineered mice sometimes fail to translate to humans?

«Importantly we contend that using juvenile rodent inactivity models will continue to provide a powerful clinical translational tool that can be used for primordial prevention of human childhood obesity.»

We investigate cellular and molecular mechanisms of retinal degeneration and regeneration using rodents and human cells as model systems.

Today, there are more DIO rodent models made using our diets than any other diets in the world.

To carry out pre-clinical testing of stem cell - derived mesDA and striatal GABAergic progenitors in rodent models of PD and HD with the goal to generate efficient and safe candidate cells for clinical use;

There has been a growing body of literature using rodents as models of human obesity, even though there are many confounding factors including species, strain, age of the animals, type of diet, level of fat, and type of control diet.

Use of genetically modified rodents for gene validation - New approaches for time saving and models of higher relevancy

To address these different topics we are developing relevant animal models that will be used in combination with primary neuronal cultures, rodent brain slices, and brain tissues.

Using neurons extracted from rodent models of Huntington's, the team employed the OPL method, which tracked the speed and efficiency with which different types of neurons were able to break down and dissolve the mutant huntingtin.

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

Partners of INFRAFRONTIER, the European Research Infrastructure for phenotyping and archiving of model mammalian genomes, offer an excellent training opportunity in using innovative technology for rodent body temperature telemetry.

To conduct the study, Sanjabi and her team created a new model of viral infection through the rectum that uses lymphocytic choriomeningitis virus (LCMV), a rodent virus often used in research to model other pathogens.

The scientists validated their findings with another RNA virus called lymphocytic choriomeningitis virus (LCMV), which is a rodent virus often used in research to model other pathogens.

Paul Sawchenko uses cell biological and genetic approaches in rodent models to study how stress - responsive systems are organized at a molecular level within the body and particularly within the brain.

T - tubules of isolated cardiomyocytes from rodent models of cardiac diseases are labelled using fluorescent dextran that diffuses from extracellular space to TATS lumen.

Since the presence of phytoestrogen containing sources (i.e. soy protein and isolated isoflavones) has been found to influence atherosclerosis and lipoprotein metabolism in various rodent models (7 - 13), the use of purified Western - type diets provides a clean «reagent» for inducing this disease.

In a second study, published in the journal Stem Cells Translational Medicine, the team showed that in rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung function.

This review will highlight commonly used dietary factors able to influence LDL - C and atherosclerosis in various rodent models, as well as some of the potential benefits and drawbacks associated with using these models for disease induction.

She will discuss the Systems Biology approaches currently used to understand the Omics results from space flight model systems (rodent, fruit fly etc) in the context of tissue response (i.e. muscle, liver, other vital organs).

While an animal model of depression may seem like an absurd idea, currently, lipopolysaccharide (LPS), an endotoxin produced by gram - negative bacteria, is used to induce these clinical models in rodents.

In other research a rodent model of TBI was used to show that CNB - 001 significantly reversed the behavioural deficits in both locomotion and memory that come with the brain injury.

Consequently, alternate - day fasting is a widely used model for studying the effects of calorie restriction in rodent species (15).

Rodents are often used in experimental conditions, and I do think they are very useful models, but it takes more protein or calorie restriction to achieve an appropriate degree of ketosis than it would with humans.

My lab is is a research unit of the Department of Surgery located on the veterinary hospital campus, primarily focused on translational research using complex nonhuman primate (NHP) disease models and screening rodent models.