Sentences with phrase «using tumor profiling»

Using tumor profiling to better understand how patients» tumors become resistant to cancer therapy

Not exact matches

«Next generation sequencing tools were used to profile patients» tumors,» said Razelle Kurzrock, MD, director of the Center for Personalized Cancer Therapy at UC San Diego Moores Cancer Center.

«We found a striking difference between the metabolic profiles of poorly aggressive and highly aggressive ovarian tumor cells, particularly with respect to their production and use of the amino acid glutamine,» said lead researcher Deepak Nagrath of Rice.

One project involves probing Foundation Medicine's growing database of tumor profiles for specific mutations and using that information to either design drugs or to parse patients into clinical trials of the company's drugs, says Pao.

Rather than simply identifying a cancer by location or tissue type, researchers now use advanced molecular profiling tests to characterize tumors, the proteins they express and the novel mutations they develop — known as neoantigens.

Such targets have recently been discovered in cell lines derived from aggressive childhood tumors using phenotypic profiling and RNAi screening.

Individual profiles based on the analysis of each patient's tumor cells revealed clinically relevant information that could be used to prioritize the drugs most likely to be effective in these cases.

They envision using this technique to create mice with tumors carrying the same genetic profile as a patient, then testing different drugs on them to see which have the best effect.

To further confirm the alteration of DDX3 expression in cancer specimens, the expression profiles of DDX3 were examined in normal - tumor paired HCC samples by immunohistochemical staining analysis using specific anti-DDX3 antibody.

Using an array of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these tumors and the clinical outcomes of patients.

To determine the genetic profile of a patient's tumor and identify cancer - driving genes, our team of experts uses advanced genomic sequencing technology.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

In precision medicine, molecular profiling of an individual patient's tumor is used to identify genetic mutations that drive that...

Co-author of the Bisgrove Phase I clinical trial published in fall 2009: A Pilot Study Using Molecular Profiling of Patients» Tumors to Find Potential Targets and Select Treatments for their Refractory Cancers.