Sentences with phrase «vhl tumour suppressor gene»

PTEN is known as a tumour suppressor gene meaning that it typically slows the growth of cells and its loss can lead to cancer.

«Over 40 % of prostate cancers lose PTEN and some lose both PTEN and another tumour suppressor gene, INPP4B, but we didn't previously have a clear picture of how this affects tumour growth,» says IMED Biotech Unit scientist Sabina Cosulich, at AstraZeneca.

Inherited mutations of the tumour suppressor gene CDKN2A are the strongest known risk factors for familial melanoma and mutations in this gene also increase the risk of other cancers.

RUNX3 is a tumour suppressor gene that prevents the formation of tumours by binding to DNA.

BRCA1 is a tumour suppressor gene involved in DNA repair through homologous recombination and in preserving the integrity of the genome.

The task is large but not insurmountable, says Rebecca: «One of the big problems with this cancer is that it doesn't have a recurrent driver gene — it's a disease dominated much more by multiple tumour suppressor genes being lost.

The adenomatous polyposis coli (APC) gene is a tumour suppressor gene, i.e. a gene preventing uncontrolled cell growth that could lead to the formation of a cancer tumour.

Homozygous deletions are rare in cancers and often target tumour suppressor genes.

Not exact matches

2003 Chinese company Shenzhen SiBiono GeneTech gains approval for treating head and neck cancer with Gendicine, a modified adenovirus carrying a tumour - suppressor gene.

A recurring theme is the overlap of these core «multicellularity» genes with genes perturbed in cancer, a disease of aberrant multicellularity (see oncogenes and tumour suppressors in Figs 2 and 3).

Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant - negative isoform, and loss of expression of the potential tumour suppressor p51.