Sentences with phrase «vhl ubiquitination»

«Our results suggest that Importin - 11 is the «Achilles» heel» of the ubiquitination system that maintains the correct levels of PTEN inside cells.»

Moffitt researchers found that SIRT1 is modified by a process called ubiquitination, in which a small residue called ubiquitin is added to SIRT1.

If cells are exposed to a drug called etoposide, SIRT1 ubiquitination blocks cell death.

However, if cells are exposed to oxidative stress, SIRT1 ubiquitination promotes cell death.

The addition of many ubiquitin molecules can target a protein for degradation, while the addition of a single ubiquitin molecule (monoubiquitination) can lead to activation of protein signaling pathways or target other proteins for ubiquitination.

The ubiquitination event is mediated directly by E1 and E2 enzymes, without the traditional involvement of an E3 enzyme.

Proteins can be regulated by a process called ubiquitination, in which an ubiquitin molecule is added to a protein.

«Ubiquitination related to transcription proteins and to DNA repair had previously been described.

In humans, there are about 100 proteins associated with ubiquitination, the process by which a protein labelled with ubiquitin is removed from the cell by specific cell machinery known as the proteosome.

But this is the first time that a protein, dDsk2, that recognises the ubiquitination of a histone, a protein that forms part of chromatin, has been identified.»

Ubiquitin receptors are involved in the detection of ubiquitination.

The study showed that FL118 inhibits p53 polyubiquitination and monoubiquitination through the oncogenic Mdm2 - MdmX E3 complex, while stimulating Mdm2 - mediated MdmX ubiquitination — by changing the target specificity of Mdm2 - MdmX E3 complex from p53 to MdmX.

Matsuda and his team found that signal - transducing adaptor protein - 2 (STAP - 2) stabilizes EGFR by inhibiting its c - CBL - mediated ubiquitination.

This stepwise process, called ubiquitination, is critical for the cell to determine which proteins need to be removed.

Such modifications, including methylation, acetylation, ubiquitination, and phosphorylation, often result in the alteration of gene expression levels that determine cell fate.

Disease - causing pathogens have been shown to manipulate or attack the ubiquitination process to disarm immune cells and evade the body's defense mechanisms, he said.

The common cellular energy source Adenosine Triphosphate, or ATP, had been used in all other observed ubiquitination and was thought necessary for the process, he said.

The researchers discovered that each protein within the family was able to independently accomplish ubiquitination.

In all ubiquitination previously observed, the cascade of three E enzymes performed a sort of relay in which one activated a ubiquitin protein, one transferred it to the target protein and one attached it, he said.

Luo and Qiu lead a research team that identified an enzyme that could independently accomplish ubiquitination, an important cellular signaling process being pursued as a therapeutic target.

The team found another unique aspect of the ubiquitination process is the use of a molecule named nicotinamide adenine dinucleotide, or NAD, as a source of energy.

«Not only does one molecule independently accomplish ubiquitination, it does this in an entirely different way.

Ubiquitination is one way a cell is told what to do through management of the proteins within it.

«If this same alternative ubiquitination process occurs in humans, perhaps an engineered ubiquitin - editing protein could be developed to target and control processes critical to the development of many diseases, including infection,» Luo said.

Ubiquitination of K - Ras enhances activation and facilitates binding to select downstream effectors.

Given their in vivo role in pathogenicity, and based on the yeast two - hybrid interaction data, these results point to the importance of these pathogen proteins in modulating host ubiquitination pathways, phagosomal escape, and actin - cytoskeleton rearrangement processes.

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF -[kappa] B signalling.

RNA interference screen reveals an essential role of Nedd4 — 2 in dopamine transporter ubiquitination and endocytosis.

The α - arrestin ARRDC3 mediates ALIX ubiquitination and G protein — coupled receptor lysosomal sorting.

On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Cbl - b, a RING - type E3 ubiquitin ligase, targets phosphatidylinositol 3 - kinase for ubiquitination in T cells.

Although several proteins have been demonstrated to be targets of Cbl - b, including the TCR itself, much of the inhibition attributable to Cbl - b results from ubiquitination of the p85α subunit of PI (3) K (21, 22).

Regulation of endoplasmic reticulum - associated degradation by RNF5 - dependent ubiquitination of JNK - associated membrane protein (JAMP).

The role of EGF receptor ubiquitination in regulating its intracellular traffic.

Serine - threonine ubiquitination mediates downregulation of BST - 2 / tetherin and relief of restricted virion release by HIV - 1 Vpu.

Protein kinase C - dependent ubiquitination and clathrin - mediated endocytosis of the cationic amino acid transporter CAT - 1.

Competitive Regulation of E-Cadherin JuxtaMembrane Domain Degradation by p120 - Catenin Binding and Hakai - Mediated Ubiquitination.

JNK - mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.

For this purpose, we have generated transgenic lines that monitor in vivo and in real - time the proliferation of β - cells using the FUCCI (Fluorescent Ubiquitination - based Cell Cycle Indicator) system.

DGKζ, a lipid kinase, phosphorylates the second messenger DAG, terminating DAG - mediated activation of RasGRP1 and PKC - θ, whereas Cbl - b, an E3 ubiquitin ligase, facilitates ubiquitination and subsequent degradation of the p85 subunit of PI (3) K. Previous studies have evaluated numerous aspects of T cell biology in the two models (16 — 18, 25, 38), but the signaling and functional effects of DKGζ deficiency and Cbl - b deficiency in T cells had not been directly compared.

AP - 2 and epsin - 1 mediate protease - activated receptor - 1 internalization via phosphorylation - and ubiquitination - dependent sorting signals.

Latham JA, Chosed RJ, Wang S, Dent SY (2011) Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination.

More specifically, he explains, «aberrant ubiquitination results in many diseases, including cancer or neurodegeneration.»

In the absence of cellular oxidative stress, Nrf2 levels in the cytoplasm are maintained at low basal levels by binding to Keap1 and Cullin 3, which leads to the degradation of Nrf2 by ubiquitination [2], [5]--[9].

Analysis was carried out using purified c - ABL and the substrate peptide, EAIYAAPFAKKK, in association with the MRC Unit on Phosphorylation and Ubiquitination, University of Dundee, Scotland.

WEHI - 435, a recently characterized small - molecule RIPK2 inhibitor, was demonstrated to delay RIPK2 ubiquitination and NFκB activation downstream of NOD2 activation.

RIPK2 is activated via tyrosine (Y)(pY474) and serine (S)(pS176) phosphorylation and ubiquitination events to allow for associations with downstream components.

RIPK2 inhibitor 1 inhibits phosphorylation at serine 176 and tyrosine 474 and possible inhibition of ubiquitination of RIPK2.

This effect is mediated by an enhanced interaction of H2AX with the E3 ubiquitin ligase RNF168, which is associated with H2AX poly - ubiquitination and promotes its degradation by the proteasome.