Not exact matches
Inna Afonina and Elien Van Nuffel under the leadership of prof Rudi Beyaert (
VIB / UGent) investigated the molecular signaling mechanism by which mutations in CARD14 lead to increased
inflammation in psoriasis patients.
Professor Rudi Beyaert (
VIB / UGent): «We found that pharmacological treatment of human skin cells with drugs that inhibit the activity of MALT1 reduced the production of
inflammation promoting proteins caused by mutant variants of CARD14.
A
VIB / UGent research team now reveals the molecular signaling mechanism by which mutations in CARD14 lead to increased
inflammation in patients with psoriasis.
Dr. Julie Deckers, Prof. Karolien De Bosscher and Prof. Hamida Hammad (all
VIB - UGent Center for
Inflammation Research) created a mouse model to look further into the relationship between the two diseases.
Dr. Julie Deckers (
VIB - UGent): «As predicted, our test showed that house dust mite - induced skin
inflammation leads to aggravated levels of allergic airway
inflammation.