Sentences with phrase «vaccine trial on»

The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees?

Not exact matches

But while thousands of clinical trials on immunotherapy drugs, of which many are predicted to fail, are springing up, the depth of information on neoantigen vaccines is much shallower: Just two studies on neoantigen vaccines for melanoma, recently profiled in Nature, were completed last year in Boston and Germany.

Following disappointing Phase 3 results for the RSV vaccine in older adults, Novavax, Inc. (NASDAQ: NVAX) reported mixed results for a Phase 2 trial of the vaccine on older adults who were reimmunized.

Most biotechs would have shuttered a clinical program that showed absolutely no efficacy whatsoever in a late - stage trial, but Novavax has instead doubled down on RSV by going forth with its phase 3 trial of the RSV F vaccine for infants via maternal immunization, and begun planning for another trial in older adults that's reportedly on track to kick off in 2018.

«Obviously one would want to have a higher efficacy when it comes to severe disease, but we're still hoping we can improve on the vaccine as we go along with the trials.»

So say scientists at Merck, who learned from trials in 2007 that their vaccine, based on a live, weakened adenovirus carrying genes for HIV proteins, was ineffective.

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

In the latest trial, reported in the October issue of the Journal of Pediatrics, the vaccine prevented 70 % of severe diarrhea cases on American Indian reservations, where incidence rates are higher than in the general U.S. population.

Testing a new vaccine on humans in a clinical trial costs tens of millions of dollars.

The recent phase 2 STEP trial of the HIV vaccine (V520) showed disappointing results, but another vaccine made by GeoVax will be moving into phase 2 clinical trials in the next few months based on promising phase 1 results.

To be sure, scientists have zeroed in on some promising vaccine - adjuvant combinations, and a few well - designed trials are now under way.

Throughout the company's trials the FDA has been on alert for signs that a patient could have a bad reaction as a result of this vaccine - making approach.

Phase II trials for that vaccine candidate are set to begin within the next two months, so it will not likely be available to combat the current swine flu outbreak, which could kill as many as 90,000 Americans and land up to 1.8 million in the hospital, according to the President's Council of Advisors on Science and Technology (PCAST).

«We are pleased to have demonstrated such a potent and durable immune response to the vaccine,» said the study's lead author, Sita Awasthi, PhD, a research associate professor of Infectious Diseases at Penn. «If found effective in clinical trials, the vaccine will have a huge impact on reducing the overall prevalence of genital herpes infections and could reduce new HIV infections as well, especially in high - burden regions of sub-Saharan Africa.»

The German biotech CureVac, for example, has brought mRNA - based vaccines for rabies and cancer to clinical trials, and Karikó now heads a research team at BioNTech in Mainz, Germany, that focuses on mRNA - based drugs.

In 2011, Science's editors will be watching a smaller detector at the Large Hadron Collider called LHCb, which will study B mesons in great detail; new techniques that should lead to the discovery of many more genes contributing to adaptation; an ignited fusion burn at the National Ignition Facility; broadly neutralizing antibodies, which are capable of disabling a wide range of viral variants; the first plug - in hybrid electric cars whose batteries are charged from a wall socket go on the market; and the results of the first phase III trial of a malaria vaccine.

CDC based its decision for children under 10 to receive two doses on preliminary data from clinical trials of the vaccines being used in the United States, but he said more complete data should emerge soon.

At the end of the trial, those who received the high - dose vaccine scored an average of 39 percent lower on symptoms and medication use than did those who got the dummy shots.

Phages would require a less traditional approach to get official approval, such as the annual process for influenza vaccines in which manufacturers secure approval of new formulas based on the flu bug that is going around that year, instead of conducting big clinical trials every time.

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

«Vaccine for malignant brain tumors: Update on phase II trial.»

Science's picks for Areas to watch in 2017 are human embryo research, Zika vaccine trials, the search for Planet Nine, and the impacts on research of the U.S. election and «Brexit» vote.

«[T] he visit also comes as the White House awaits action from Congress on a nearly $ 6.2 billion emergency appropriations request to continue fighting [Ebola] in West Africa and to move candidate vaccines through clinical trials.

Dr Welaga says that researchers should consider testing the effect of measles vaccines and other routine vaccines on all - cause mortality in randomized trials.

«The findings from this trial are very encouraging to those of us who have spent many years working on vaccine candidates to protect against dengue, a disease that is a significant burden in much of the world and is now endemic in Puerto Rico,» said Stephen Whitehead, Ph.D., of NIH's National Institute of Allergy and Infectious Diseases (NIAID).

Vaccine efficacy was set at an average of 60 % (actual numbers depended on the different virus subtypes and on whether a person had been exposed due to a prior natural infection) based on recent phase III trial results for the Sanofi - Pasteur vaccine that had shown moderate effectiVaccine efficacy was set at an average of 60 % (actual numbers depended on the different virus subtypes and on whether a person had been exposed due to a prior natural infection) based on recent phase III trial results for the Sanofi - Pasteur vaccine that had shown moderate effectivaccine that had shown moderate effectiveness.

Just a few weeks ago, WHO said that using any of the experimental drugs or vaccines in the pipeline simply wasn't in the cards, because none of them have been through a phase I clinical study, the type of trial in which medical products are tested on healthy volunteers to study their toxicity.

The latest vaccine experiments aim to build on the modest success of a trial in Thailand in 2009, when an earlier vaccine showed a 31 percent reduction in infections.

In their new study, researchers from the Johns Hopkins Bloomberg School of Public Health, Imperial College London and the University of Florida re-analyzed data from vaccine trials conducted in 10 countries with more than 30,000 participants as well as recently published data on the long - term follow - up of these participants.

On 31 July, The Lancet published the interim results of a clinical trial in Guinea that showed that an Ebola vaccine produced by Merck appears to be highly effective.

The vaccine, which is about to go on trial in the US, aims to re-educate T cells so that they no longer react to the dander.

Howard Weiner, Danny Frenkel, and their colleagues built on the results of a failed 2003 Alzheimer's vaccine trial.

Vaccine developers are trying to improve vaccines for transplant recipients and other people with a weak immune system, and the samples used in this study came from a clinical trial of different versions of a flu vaccine in patients on immune - suppressiveVaccine developers are trying to improve vaccines for transplant recipients and other people with a weak immune system, and the samples used in this study came from a clinical trial of different versions of a flu vaccine in patients on immune - suppressivevaccine in patients on immune - suppressive drugs.

Vaccine trials started last week, and initial observations are promising, but Donnelly and her team warn that it will take many months to scale up production sufficiently to start having an effect on the current epidemic.

So far in tests on mice, plant proteins have worked as well as traditional vaccines, and the U.S. Navy is planning human trials later this year.

A new clinical trial in which the vaccine will be given intravenously to 51 volunteers is scheduled to start next month at VCR; another trial in Tanzania is on the drawing board.

«To rid the world of meningitis epidemics altogether, we need to go after all the major strains in one public health vaccine,» noted Adar Poonawalla, CEO and executive director of Serum Institute of India Private Ltd. «We are partnering with PATH on a pentavalent meningitis vaccine — targeting five meningitis strains, A, C, W, X, and Y — and will begin clinical trials this year.»

If the other trials bear out the Colombian findings or improve on them, the vaccine will be needed in larger quantities.

Based in part on these results, the Butantan Institute in São Paulo, Brazil, this year launched an efficacy trial of the vaccine that plans to enroll 17,000 people.

The problem with traditional methods of vaccine development is that they depend on a great deal of trial and error: researchers develop a compound they think should cause an immune response in the body and then test it on thousands of people, hoping to see a positive change.

Up until now, efforts in generating a vaccine against TB have been mainly focused on T cells (cells from the adaptive arm of our immune response with memory capacity), with very disappointing outcomes in both pre-clinical as well as clinical trials.

An Ebola vaccine made by GlaxoSmithKline (GSK) in Rixensart, Belgium, is the furthest along, having entered phase I human trials on 2 September.

Merck began a second trial of its vaccine in February in South Africa, where the circulating virus differs from the one the vaccine is based on.

Nelson Michael of the Walter Reed Army Institute of Research in Silver Spring, Maryland, says that the trial Zika vaccine will be tested on mice and monkeys that already have antibodies to dengue, to see if that interferes with the vaccine.

A clinical trial in humans of a vaccine based on Ab antibodies was halted in 2002 because 5 percent of the patients developed encephalitis.

Those who oppose the trial think the approach with the greatest chance of success would be to test a vaccine based on one subtype in a population at risk from the same subtype.

The vaccines were developed for strains of the virus more commonly found in white women, on whom the clinical trials had been based.

Activists often slam large pharmaceutical companies for failing to develop drugs that are of critical importance to the developing world.Andrew Witty, GlaxoSmithKline's youthful chief executive, gave those critics pause yesterday in a speech to the Council on Foreign Relations in New York City.Witty promised to sell the company's malaria vaccine that is in late - stage clinical trials in Africa for no more than a 5 percent profit.

Led by University of Texas Austin researcher Dr Steve Bellan, and in collaboration with the U.S. Centers for Disease Control and Prevention (CDC), the study on the design of CDC's vaccine trial in Sierra Leone is published in The Lancet Infectious Diseases.

Key figures share their perspectives on a controversy that led to the suspension of Ebola vaccine clinical trials in Ghana.