Vaccine trials started last week, and initial observations are promising, but Donnelly and her team warn that it will take many months to scale up production sufficiently to start having an effect on the current epidemic.
Not exact matches
A top U.S. health official says long - anticipated clinical
trials of a possible Ebola
vaccine will
start soon in West Africa.
The long search for an AIDS
vaccine has produced countless false
starts and repeated failed
trials, casting once bright hopes into shadows of disenchantment.
After years of false
starts, a new generation of DNA
vaccines and medicines for HIV, influenza and other stubborn illnesses is now in clinical
trials
The company is
starting larger
trials to see if the
vaccine can actually protect people from getting sick.
In 1991 the WHO decided to support Uganda, Rwanda, Thailand and Brazil in preparing for the first field
trials of AIDS
vaccines, but of these only Thailand is close to
starting a
trial.
And this week clinical
trials for a potential Ebola
vaccine will be
starting at the National Institutes of Health.
They will also work with Vir Biotechnology, Inc. of San Francisco, which has licensed aspects of their CMV - based
vaccine approach, to expand testing with plans to
start a human clinical
trial in 2020.
«We observed rapid and durable protective immunity without adverse events, and so we think this candidate
vaccine represents a promising strategy for the global fight against Zika virus,» said senior author Drew Weissman, MD, PhD, a professor of Infectious Disease at Penn. «We hope to
start clinical
trials in 12 to 18 months.»
Human safety
trials for a
vaccine to jump -
start immunity could begin later this year; larger efficacy
trials may be a year and a half away.
Trials of the
vaccine therapy are planned to
start later this year at Massachusetts General Hospital in Boston, Johns Hopkins Medical Center in Baltimore, the Queensland Institute of Medical Research (QIMR) in Brisbane and the Royal Netherlands Cancer Institute in Amsterdam.
Tested in a U.S. - sponsored
trial that involved more than 16,000 volunteers in Thailand, the
vaccine was administered in six injected doses
starting in 2006 to half of the group, and the other half received a placebo.
Today, anti-dengue
vaccines that primarily evoke antibody responses are in clinical
trials or
starting to be licensed in certain countries but show only moderate success.
A new clinical
trial in which the
vaccine will be given intravenously to 51 volunteers is scheduled to
start next month at VCR; another
trial in Tanzania is on the drawing board.
A
Vaccine against Epstein - Barr virus, which causes glandular fever and is implicated in several cancers, will
start trials in people within a year.
Negotiations with the U.S. company that holds the license for commercialization of the
vaccine — which contains a gene for the Ebola surface protein stitched into a livestock pathogen known as vesicular stomatitis virus (VSV)-- have needlessly delayed the
start of the
trial, Becker and several other scientists tell Science.
But for a clinical
trial to
start, regulators require information about how the
vaccine was manufactured, and that resides with NewLink Genetics, which has been slow to release it, people familiar with the negotiations say.
A second
trial would
start simultaneously in Sierra Leone, Ripley Ballou, who is heading the GSK Ebola
vaccine project, told ScienceInsider.
Vaccine trials are
starting but there won't be enough doses to make a difference until April — by which time the epidemic may have peaked in some regions
Though health officials were already «cutting corners» in an effort to produce an Ebola
vaccine, Collins said that a best - case scenario would be for a clinical
trial to
start in December, and it would take until February or March to know if the drug worked.
«But, overall, this report illustrates well the current rapid pace of Zika
vaccine development and one US company (Inovio) reported recently plans to
start a
trial of their DNA
vaccine technology for Zika very soon.»
The
trials would be for proof of concept, to show whether researchers can, for the first time in humans, stimulate the right B cells to
start the process of making broadly neutralizing antibodies, long considered the «holy grail» of HIV
vaccine research because they defend against infection by a broad spectrum of HIV strains.
In 2005, Dan co-founded and served as President and CEO of Inviragen Inc., which he transformed from a virtual
start - up to a global clinical stage company with sites in Colorado, Wisconsin and Singapore and translated two
vaccines from the research bench to human clinical
trials, including one for dengue fever.
... Three small
trials of the same
vaccines will
start in Thailand during the next year; they should further clarify the role of V1 / V2 antibodies in protection, COL Jerome Kim says.
The same year, the FDA approved the
start of the first human clinical
trial of this
vaccine that demonstrated its safety and efficacy at inducing an immune response against the virus.
This rapid sequencing was one factors that meant
vaccine trials could be
started in February 2015, less than one year after the epidemic had been recognised.