But that all came to an end in 2002, when
the WHI clinical trial dealt HRT a death blow.
The National Heart, Lung and Blood Institute of the U.S. Department of Health and Human Services, the National Cancer Institute and Wyeth - Ayerst Research Laboratories funded the study, which involved researchers at nine institutions and 15
WHI clinical - study sites nationwide.
«I was surprised by the magnitude of the effect — the doubling of breast density associated with combination - hormone therapy,» said McTiernan, lead physician of
the WHI Clinical Coordinating Center, which is based at Fred Hutchinson.
Not exact matches
Ross Prentice, lead investigator of the
WHI breast cancer study, defends the importance of
clinical trials.
The
WHI wasn't the first such highly touted
clinical trial that did not live up to expectations.
On the basis of HERS and other secondary prevention trials, the American Heart Association recommended against initiating postmenopausal hormones for the secondary prevention of cardiovascular disease.43 The American Heart Association made no firm recommendation for primary prevention while awaiting the results from randomized
clinical trials such as
WHI, and stated that continuation of the treatment should be considered on the basis of established noncoronary benefits and risks, possible coronary benefits and risks, and patient preference.