Sentences with phrase «whi trial»

Some women objected to the use of pregnant mares» urine — the source of estrogen in oral conjugated equine estrogens (Premarin), the only estrogen tested in the WHI trial.

Dr. Manson was a coauthor on a March 2008 study in the Journal of the American Medical Association that followed up on the WHI trial.

The WHI trial results provide the first definitive data on which to base treatment recommendations for healthy postmenopausal women with an intact uterus.

The authors analyzed the relationship between the blood levels of vitamin D and a number of menopause symptoms, including hot flashes, night sweats, sleep disturbance, concentration, and forgetfulness in 530 women who participated in the calcium and vitamin D WHI trial.

Based on an evaluation of nearly 22,000 women included in the WHI trials, women aged younger than 40 years already in menopause had significantly higher risks for fracture than women who experienced menopause between the ages of 40 and 49 or after 50, regardless of treatment intervention.

Not exact matches

The WHI hormone therapy trials assessed heart disease, breast cancer, stroke, blood clots, colorectal cancer, hip fractures and deaths from other causes in women who used the hormones versus those who took a placebo.

The trial, part of a multifaceted project called the Women's Health Initiative, or WHI, was meant to examine hormone therapy's effectiveness in lowering the risk of heart disease and other conditions in women ages 50 to 79.

Recently, Manson and colleagues published a long - term study of the risk of death in women in the two WHI hormone therapy trials — combined therapy and estrogen alone — from the time of trial enrollment in the mid-1990s until the end of 2014.

Along with the focus on prevention, the WHI hormone therapy trials were largely studies of older women — in their 60s and 70s.

Ross Prentice, lead investigator of the WHI breast cancer study, defends the importance of clinical trials.

The WHI wasn't the first such highly touted clinical trial that did not live up to expectations.

The study involved a randomly selected subgroup of 413 racially and ethnically diverse postmenopausal women, ages 50 to 79, who were participants in the WHI estrogen - plus - progestin trial, which involved more than 16,500 women nationwide.

Hazard ratios (HRs) were estimated using Cox proportional hazards models stratified by age, prior disease (if appropriate), and randomization status in the WHI dietary modification trial.

On the basis of HERS and other secondary prevention trials, the American Heart Association recommended against initiating postmenopausal hormones for the secondary prevention of cardiovascular disease.43 The American Heart Association made no firm recommendation for primary prevention while awaiting the results from randomized clinical trials such as WHI, and stated that continuation of the treatment should be considered on the basis of established noncoronary benefits and risks, possible coronary benefits and risks, and patient preference.

But that all came to an end in 2002, when the WHI clinical trial dealt HRT a death blow.

«In the Womens Health Initiative (WHI) trial, when women got seven years of estrogen alone, there was no increased risk of breast cancer, but after four to five years on combined hormone therapy, the risk emerges,» she says.