Sentences with phrase «wnt signaling pathway»

Because miR - 142 is upregulated in the BCSCs and stimulates the canonical WNT signaling pathway that is an important regulator of the stem cell properties in mammary tissues, we tested the ability of miR - 142 to regulate the organoid formation of BCSCs.

We note that our results show that miR - 142 upregulates the expression of miR - 150 when miR - 142 is highly expressed and / or the WNT signaling pathway is strongly stimulated in mammary epithelial cells.

In this study, we report that miR - 142 efficiently recruits the APC mRNA to an RNA - induced silencing complex, activates the canonical WNT signaling pathway in an APC - suppression dependent manner, and activates the expression of miR - 150.

Because each miRNA has multiple target genes, we speculate that the presence of many other target genes with higher affinity to the miR -150-containing RISC will perturb the ability of miR - 150 to regulate the APC mRNA and that miR - 150 has much weaker effect, if any, on the WNT signaling pathway in vivo.

We note that our new results show that miR - 142 upregulates the expression of miR - 150 when miR - 142 is highly expressed and / or the Wnt signaling pathway is strongly stimulated in mammary epithelial cells.

1) The results of the inhibition of miR -142-3p in the human breast cancer xenograft cells and the Wnt signaling pathway inhibition in human breast cancer cells have confirmed that our finding that miR - 142 targets APC, activates the Wnt signaling pathway and upregulates miR - 150 is applicable to human breast cancers.

«Any miscues with the Wnt signaling pathway,» says Katsanis, «and you're looking at major childhood diseases and defects.»

Surrozen is a biotechnology company focused on discovering and developing novel regenerative medicines with a focus on unlocking the powerful self - renewal properties of the body through specific control of the Wnt signaling pathway.

Because both notum and the Wnt signaling pathway are so evolutionarily ancient, their interaction in planarians may indicate a relationship that is important in other animals as well.

In particular, the lab studies the non-canonical Wnt signaling pathway, which comprises a family of proteins with great implications in fetal development as well as cancer.

Novel Role for the Innate Immune Receptor Toll - Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis.

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

The ortholog genes that were found to be associated with cartilage development, along with bmp which acts as a key member gene, are known to be involved in the Wnt signaling pathway (Kim et al., 2013; Lin & Hankenson, 2011).

Among the total gene transcripts that were differentially expressed during daytime six biological processes were found: Wnt signaling pathway, cell junction organization, SMAD binding, regulation of cell morphogenesis, TGF - β signaling pathway, and amino acid synthesis (Fig. 4A).

Taken together, these results suggest that CSCs are essential for metastatic colonization and that CSCs induce stromal fibroblasts to secrete POSTN in the metastatic niche to support tumor cell outgrowth by augmenting the Wnt signaling pathway.

Researchers also know that a cellular pathway called the Wnt signaling pathway induces hair growth.

«We concluded that RAC1 regulates lung branching morphogenesis, in part through the so - called canonical Wnt signaling pathway, which leads to the regulation of the transcription of many genes,» said principal investigator Denise Al Alam, PhD, of the Department of Surgery and the Developmental Biology and Regenerative Medicine Program at The Saban Research Institute.

In their new paper, Cheyette and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active in tissues of the brain and interacts with DISC1, a gene implicated in schizophrenia, depression, bipolar disorder, and autism spectrum disorders.

Taken together, the findings demonstrate that the GRN mutation causes the defect in cortical neuron formation by altering the Wnt signaling pathway.

One of the top defective pathways in the iPSCs was the Wnt signaling pathway, which plays an important role in neuronal development.

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

Looking at the mechanism downstream, the researchers found that the loss of Cbf - beta impeded the canonical Wnt signaling pathway, particularly through decreased Wnt10b expression.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

«We discovered that three particular proteins involved in the Wnt signaling pathway aren't just involved in the development of severe illnesses, but also in the qualitative refinement of highly developed tissue,» says co-first author Claudio Cantù from the molecular biologist research group lead by Prof. Konrad Basler.

Researchers filled in other details about the selective role of LKB1 in regulatory T cells, including that the molecule unexpectedly works through the Wnt signaling pathway to adjust regulatory T cell function.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

According to Prof. Holstein, the origin of the first nerve cells depends on the Wnt signal pathway, named for its signal protein, Wnt.

«There has been a lot of work on Wnt signaling pathways, for example, so there are a lot of small - molecule drugs that could be tested to trigger a stem cell to mature into a neuron.»

Birgit Kagermeier - Schenk (Weidinger, TUD)-- «Genome - wide analysis of Wnt / beta - catenin target genes in zebrafish embryogenesis and characterization of a novel modifier of Wnt signaling pathways» (2010)

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.

Adenoma (benign tumour) formation - driven by mutational activation of the Wnt signalling pathway in intestinal stem cells

Aulicino F, Theka I, Ombrato L, * Lluis F, * Cosma MP (2014) Temporal perturbation of the Wnt signalling pathway controls cell reprogramming via Tcf1 activity.

Not exact matches

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

The study also found that some of the morphing genes in the python's intestine, notably those in a signaling pathway called WNT, were genes that were involved in intestinal and other cancers.

OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells.

Through many painstaking experiments, she zeroed in on a signaling pathway called Wnt, known to be important in mouse lung development.

«We also showed for the first time that AHR signaling in primary human orbital fibroblasts disrupts the pro-fibrotic Wnt / β - catenin pathway, which is important for scar cell formation,» noted Dr. Phipps.

Researchers at the Center for Regenerative Medicine (CReM) at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have discovered that one particular signaling pathway, Wnt, helps direct lung development.

«When we blocked the Wnt - signaling pathway in mice with amputated fingertips, the nail and bone did not grow back as they normally would,» says Dr. Ito.

NANCI appears to act upstream of Nkx2.1, but down - stream of Wnt signaling, a critical pathway for specifying cell type later in lung tissue development.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

Named after the BMP signal protein, this pathway controls the evolution of various cell types depending on the protein concentration, similar to the Wnt pathway, but in a different direction.

The Wnt / β - catenin signaling pathway and microRNA 335 are instrumental in helping form differentiated progenitor cells from stem cells.

Professor Heiko Lickert, director of the IDR, in collaboration with Professor Gunnar Schotta of LMU München, showed that the Wnt / β - catenin signaling pathway regulates Sox17, which in turn regulates molecular programs that assign pluripotent cells to the endoderm, thus inducing an initial differentiation of the stem cells.

«The cool thing is that this raises the question of whether our common ancestor used these pathways — Wnt and Bmp signaling — to regenerate or not.»

Interestingly, a previous STEM CELLS study from Janeczek et al. [3] established that activating the WNT signaling «pathway in BM led to the generation of an osteogenically enhanced subset of stem cells.

The Wnt, Shh, BMP, Insulin / IGF, and FGF signaling pathways have all been implicated in establishing and maintaining the adult retinal stem cell niche (reviewed in [34]--[37]-RRB-.

Inhibition of signaling pathways, especially of the Wnt / β - catenin and hedgehog transduction cascades are newly described modalities involved in antitumor activity of the anthelminthics.

Yao H, Ashihara E, Maekawa T. Targeting the Wnt / β - catenin signaling pathway in human cancers.