Sentences with phrase «wt htt»

More research is needed to further explore the role of WT htt in the adult as well as to determine what level of adult WT htt knockdown will be permissible while attempting to reduce the mutant Htt protein.

In order to better understand the liabilities associated with reducing normal htt in adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycycline.

Reduction of endogenous striatal htt using siRNA in rats expressing Htt171 - 82Q had no further detrimental effect on neuronal survival nor htt inclusion load indicating that partial inactivation of endogenous WT htt in the adult striatum (~ 50 %) had no major impact on the course of HD pathology (Drouet et al, 2009).

Not exact matches

Expression of mutant Htt appeared to alter the firing rate of STN neurons, as firing rates in HET and HOM mice were lower than their WT littermate.

We present here the first comprehensive behavioral analysis of the effects of a conditional knock - down (starting at 4.5 weeks of age) of WT endogenous htt in adult mice in the absence of any potential mutant gain - of - function.

These results highlight the potential toxic liabilities of therapies aimed at significantly reducing both WT and MT htt and indicate the need for a better understanding of the lower limits of htt suppression that can be tolerated prior to the onset of toxicity.