Sanger Researchers, Collaborators Uncover
Warfarin Response Genes in Large GWAS GenomeWeb News - Nov 14, 2008
Our objective was to examine the effect of genetic variability in the CYP4F gene cluster on expression of the individual CYP4F genes and
warfarin response.
Not exact matches
More potent coumarins were developed as a
response to
warfarin resistance in the mid-1970s and are now more widely used than
warfarin, but it is not uncommon for the
warfarin resistance gene to mutate further so that the rats become invulnerable to these chemicals too.
In addition to
warfarin, he is also in involves in other pharmacogenetic studies such as clopidogrel
response, NSAID induced angioedema, drug induced Stevens - Johnson Syndrome and clinical studies using pharmacogenetic markers.
Many studies have focused on identifying the genetic factors influencing an individual's
response to
warfarin.
Pharmacogenetics tests, such as CYP2C19 or
Warfarin Sensitivity, help predict a patient's individual
response to a given medication, allowing for highly personalized treatment plans.