Sentences with phrase «when telomeres»

When your telomeres are healthy, your cells divide normally, meaning your body's tissues renew and regenerate properly.

When telomeres start wearing away, cells are no longer dividing properly and your body starts exhibiting signs of internal and external aging.

Telomeres protect a cell's chromosomes from fusing with each other or rearranging — abnormalities which can lead to cancer — and so cells are normally destroyed when their telomeres are consumed.

This exhaustion of proliferative potential, called senescence, can be triggered when telomeres — the ends of linear chromosomes - can not fulfil their normal protective functions.

Titia's studies have also informed us on what happens when telomeres are shortened or when their numbers are depleted, shedding a light on the processes that can lead to cancer.

Scientists think that normal cells, which apparently lack the telomerase enzyme, stop dividing and die off appropriately after 50 to 100 divisions when their telomeres are worn to the nub.

When the telomeres are worn away, the chromosomes become vulnerable to mutations, possibly paving the way for age - related diseases such as atherosclerosis and certain cancers.

Cell - culture studies show that when telomeres can no longer shield chromosomes from damage, cells stop dividing or become unstable.

«Nevertheless, we have evidence that the second step has to happen, and that the second step is initiated by or is occurring at a time where telomeres are critically short and when telomeres can be dysfunctional and drive genomic instability,» he said.

When the telomeres get too short, the ends stick to one another, wreaking havoc when the cell divides and in most cases killing the cell.

But cells stop dividing and die when telomeres drop below a certain length — a normal part of ageing.

When your telomeres are finally eaten away after many years, your cells begin to show signs of age, and this process may be a key part of what makes us grow old.

It potentially also suggests applications for the human ageing process even at old age when telomere length has already decreased,» said Dr Grishma Rane, Research Fellow at CSI Singapore and co-first author of the study.

While everyone's telomeres dwindle as they grow older, a big split occurs after age 50, when telomere shortening among men accelerates.

Not exact matches

First a chromosome is catastrophically shattered when it loses the caps on its ends, known as telomeres, that hold it together.

Blackburn and Szostak determined that it was a specific DNA sequence in the telomeres that kept chromosomes from fraying whenever they were copied when a cell splits in two.

The changes were observed by Mats Olsson of the University of Wollongong in New South Wales, Australia, and colleagues when they measured the telomeres of wild sand lizards, Lacerta agilis (Biology Letters, DOI: 10.1098 / rsbl.2010.0126).

12 Telomeres, sequences of DNA at the tips of chromosomes, get shorter every time a cell divides; when they get too short, the cell dies.

The personal telomere test, like the personal genome test, is coming at a time when we've still got many more questions about what it will reveal than solid answers.

The key to cancer cell immortality are the cell's telomeres, repetitive stretches of DNA at the ends of chromosomes that may protect the chromosomes when they divide.

Mariela Jaskelioff and her colleagues at the Dana Farber Cancer Institute in Boston, Massachusetts, engineered mice with short telomeres and inactive telomerase to see what would happen when they turned the enzyme back on.

With each division the telomere would shorten by a notch from whatever it had been when we took telomerase out.

If cells fail to turn up telomerase, they also fail to immortalize, and eventually die from short telomeres because chromosomes stick together and then shatter when the cell divides.

The gender division continues to widen until about age 75, when those with the blunted telomeres die from disease.

When imposing repair on broken DNA strands during mitosis, some telomeres are seen to fuse together (one dot).

Telomeres are the caps at the end of chromosomes that keep them from shrinking when cells replicate.

The other weird thing was when we dampened down the level of telomerase, the cells didn't run out of telomeres.

Usually, when a cell makes a copy of itself, the telomeres shorten, which may explain why cells age and die.

Telomerase is an enzyme that replicates the ends of chromosomes (sections of DNA called telomeres), replacing the DNA lost when chromosomes are copied before cell division and, therefore, maintaining the stability of the genome.

Because when Carol [Greider] and I first discovered this enzyme in 1985, we thought of it as being a humble bricklayer that ploddingly puts nucleotides together and builds up this little wall of telomeres.

The finding relates to telomeres, the caps that protect the tips of chromosomes when cells divide.

They found that when chicks first hatched, there was no effect of parental age on offspring telomere length, suggesting there were no pre-natal effects of parental age.

When researchers took a close look at the cells of Dolly, the cloned sheep, they found that her telomeres, the caps on the ends of the chromosomes, were shorter than normal.

Lundblad's group has engineered yeast cells that lack telomerase, to study how cells respond to eroding telomeres when telomerase is not present to counter-balance.

When Dolly the cloned sheep died at the premature age of 6, scientists discovered unusually short telomeres in her cells.

Experts consider telomeres — the protective ends of chromosomes — when calculating this age difference.

When Szostak heard about Blackburn's Tetrahymena repeat sequences, he proposed testing whether they would function as telomeres in his yeast system.

Telomeres are longest when we're young and naturally shorten as we age.

Every time DNA replicates, the telomeres get slightly shorter and eventually when they get small enough, the process of cell death begins.

When a group of the participants was tested at five years, their telomeres had increased in length compared to a control group who had shortened during that time period.

After each new replication the telomeres shorten until they reach a critical length when they stop dividing, begin to «age» and ultimately die.4 Scientific laboratories like SpectraCell now provide telomere testing as «a window into your cellular age.»

Telomeres keep your cells young and keep them from losing genetic information when your cells divide.

It's an herb that generally reduces a lot of this stress or the jitteriness that might be accompanied by a little bit of coffee, and they also blend it with astragalus which is a longevity herb that when paired with all the antioxidants in coffee is a match made in telomere - longevity enhancing heaven.

My simple blood test showed that when I was 44 years of age, I had the shortened telomeres of a 64 - year - old woman.

If that's not enough to get your attention, another silent and insidious problem is that you may lose bone strength and bone density when cortisol is high, [i] although this is not conclusively proven in women of all ages, [ii] nor is it absolutely clear that run - of - the - mill chronic stress is causal when it comes to bone loss (though it certainly shortens telomeres).

I'm just wondering, when Ornish says that a vegan diet along with exercise can boost telomere strength — how much exercise must one do?