Sentences with phrase «while significant advances»

While significant advances in the treatment for kidney cancer over the last decade have led to the approval of a dozen drugs, these drugs are mostly palliative, lacking the potential for cure.

Not exact matches

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

When women routinely win Nobel Prizes in physics, chemistry or medicine, when a woman becomes a world chess champion, when a woman conceives and develops a brand new computer chip that represents a significant advancement over quad cores, when a woman invents warp drive or phasers, when a woman solves an «insolvable» math problem, when a woman, while working with the Large Hadron Collider, discovers the now - hypothetical Higgs Boson to be an actual scalar subatomic particle, when a woman figures out how to pinpoint the exact location of an electron at any point in time, when a woman working for Merck or Pfizer develops a remedy for Alzheimer's disease, when a woman's baseball team can defeat the New York Yankees, when a woman can bench press six hundred pounds, run the 100 meter dash in under nine seconds or set a world record in the high jump, then the fairer sex will have made an advance or contribution unlike any it has made before.

While these teams measure up pretty similarly when it comes to a number of advanced metrics, FIU does have a significant advantage in the red zone, where they rank second in the country in scoring percentage, while Temple ranks While these teams measure up pretty similarly when it comes to a number of advanced metrics, FIU does have a significant advantage in the red zone, where they rank second in the country in scoring percentage, while Temple ranks while Temple ranks 96th.

Impact sensor technology, while still obviously in its infancy, holds out the promise, in my view and that of many others, of becoming the most significant advance in concussion safety, ever.

The Senate GOP has allowed for key votes on the legalization of same - sex marriage and gun control, while Cuomo has also racked up significant economic victories, including a property - tax cap and three budgets in a row passing in advance of the April 1 deadline.

By committing significant funding and support to advanced technology, sciences and R&D institutions, New York is laying the groundwork for new jobs and new economic development opportunities, while ensuring that Long Island continues to attract the best of the best to establish roots here and join our great community.»

While Mr. de Blasio faced significant challenges advancing his agenda this year in Albany and Washington, it has been the opposite at the City Council, where fellow Democrat Ms. Mark - Viverito has helped him win approval on a number of planks from his 2013 mayoral campaign.

The court also will be asked to decide whether the Fifth Circuit erred in concluding that this standard permits Texas to enforce, in nearly all circumstances, laws that would cause a significant reduction in the availability of abortion services while failing to advance the state's interest in promoting health — or other valid interest.

Significant advances have been made in chemotherapy over the past decade, but targeting drugs to cancer cells while avoiding healthy tissues continues to be a major challenge.

Andrews says the team's research marks an important turning point in the field because it represents a significant advance toward solving the cathode problem while also highlighting the inherent advantages of using much more imaginative, metastable materials like this new form of vanadium pentoxide.

«While medication and therapist - led interventions have shown some benefit for select survivors, online training marks a significant advance by giving survivors convenient access to an effective intervention.»

While the number of platelets produced per megakaryocyte was lower than normally made in the body, the researchers note that the system represents a significant advance over previous models.

These carbon nanotube quantum light emitters may be important for optically - based quantum information processing and information security, while also being of significant interest for ultrasensitive sensing, metrology and imaging needs and as photon sources for fundamental advances in quantum optics studies.

Overall, this report offers strong evidence that Building America's investments have advanced the American homebuilding landscape while yielding significant dividends for taxpayers.

While an earlier study had shown a similar immunotherapy drug to be effective for a significant proportion of patients with advanced melanoma or lung or kidney cancer, checkpoint inhibitors weren't making headway with colon cancer.

While its causes are not fully understood, significant advances in its diagnosis and treatment have been made in the past 25 years.

While there were no significant overall gains among students of other ethnic groups, black students in their second year of private - school attendance improved their test scores by 6.3 percentile points — a striking advance at a time when schools around the country are trying to close a persistent gap between scores of white and black students.

While teaching 3rd grade, 22 out of my 23 students received a score of «advanced» on the ISAT, and ALL students demonstrated significant growth on their MAP math scores.

While the field of teacher preparation has made significant advances in recent decades — creating stronger clinical partnerships, developing better performance assessments, making better use of newly available data sources, meeting more demanding state approval and national accreditation standards, and developing new models and patterns of preparation — not all of these advances have been universally adopted at the program level.3 To consolidate the gains and to overcome challenges to implementing universal high standards for admission and academic rigor in teacher preparation, states, school districts, and teacher preparation programs must work together to enact key policy changes.

The strong utilization of TIFIA credit assistance for the wide array of projects described in this report demonstrates the significant importance of the program to advance infrastructure investments across the United States while ensuring private sector engagement in infrastructure financing.

Advanced driver assistance systems, significant suspension and steering improvements, and available intelligent AWD vastly improve the Kia Sportage's driving dynamics while premium materials and world - class craftsmanship create a class - up experience in an otherwise utilitarian segment.

The Kia Niro received a «dual rating» from Euro NCAP; the standard car achieved a four - star safety rating, while a model featuring the optional «advanced driving assistance pack» was awarded the full five stars thanks to the significant improvements to scores in the pedestrian protection and safety assist categories.

This advanced technology has true potential to keep the entire family safe while also reducing the risk of an accident by a significant margin.

While ASG's study reveals that these advanced powertrains are largely responsible for leading significant fleet fuel economy gains in 2018, there is one notable model with a conventional powertrain that is a standout in the API.

While these numbers may seem impressive at first glance, as Robin Birtle (CEO at Sakkam Press in Tokyo) noted recently on TeleRead they «belie the fact that comics make up 75 % of the revenue, and apart from comics and magazines, there seems little significant advance in broadening the e-book customer base within Japan.»

Finally, while it's important to be aware of — and prepare in advance for — the impact a market downturn might have on your retirement prospects, you should also keep in mind that even a significant market setback doesn't necessarily doom you to a post-career life of penury.

Twilio posted a solid month in February, showing extremely high rates of revenue growth of greater than 60 % outside of Uber, while gross margins were stable, which led to the stock's significant advance.

Worst of all, it suffers from the Yellen collar (which I wrote about here)-- the Fed put's still there under the market (but with a much tighter strike than the Greenspan era), while any significant market advance will prompt the Fed to raise rates.

Graphically, Wolfenstein II: The New Colossus has had an engine upgrade in comparison to its prequel as Wolfenstein: The New Order was running on the id Tech 5 engine, while Wolfenstein II is powered by id Tech 6 resulting in the introduction of significant graphical enhancements including dynamic lighting effects and advanced particle effects.

While these funds may be spent on any advanced technology, it is likely that a significant portion will be spent on plug - in vehicle technologies.

The continued shrinkage of thaw ponds could bring significant changes to local ecosystems, as spruce forest is likely to supplant tundra as the dominant land cover.14, 20 This could lead to a northward advance of some species of plants and other trees, while leaving resident vegetation more vulnerable to early mortality — potentially further disrupting the climate.14, 20,21

Doing so effectively calls for research skills beyond those that students acquire through working with domestic legal resources.56 Mary Rumsey explains that students must go beyond their dependence on domestic databases to learn how to access the different resources relevant to international and comparative law.57 She describes, as examples, the need to find customary international law through treaties, laws of other nations, diplomatic correspondence, and scholarly works, and she points out that civil law research requires much more emphasis on statutes and scholarship than on the case law that plays such a dominant role in American legal analysis.58 While there have been significant advances in access to foreign and international legal sources, there are still substantial barriers, 59 and the research methods needed to obtain these resources can be different (in ways either subtle or stark) from those that apply to domestic law.

While the long - awaited new corebot and missions are the main draw of this update, some significant technical advances have also been made.

While voice recognition technology advanced in a significant manner in recent years, it still requires users to be relatively close to the microphones that are capturing their commands, which is why not even shouting at one's smart speaker across the room is always a reliable method of controlling smart devices and even if it was, its efficiency is less than ideal.

The tide has turned in the cryptocurrency segment today, as the recent short - term trends reversed with most of the major altcoins losing significant ground, led by Ripple, while Bitcoin advancing after a period of underperformance.

Professional Duties & Responsibilities Directed professional installation of advanced residential and commercial satellite television and internet Oversaw, trained, and reviewed customer service, sales, and installation staff ensuring effective operations Directly responsible for approximately 50 technicians at 5 offices throughout the region Designed and implemented training workshops for certification in Satellite Internet System installation Successfully reduced staff turnover while improving team skill sets and morale Responsible for multimillion dollar company inventory, tools, and vehicles Generated significant sales through cold calling, networking, and other sales tactics Consistently exceeded service goals through effective scheduling, routing, and relationship management Authored company sales and service reports and presented to senior leadership Delivered exceptional customer service resulting in client satisfaction, repeat business, and referrals Resolved customer service inquiries in a timely, positive, and professional manner Built and strengthened relationships with key clients, partners, and industry leaders Consistently promoted and awarded for excellence in sales, customer service, and leadership

While a significantly lower proportion of participants in the advance provision group (47 %) reported condom use at last intercourse than in the clinic access group (54 %), this difference was not significant after adjusting for race / ethnicity and clinic site (OR, 0.79; 95 % CI, 0.60 - 1.04, P =.09).

While several investigators have demonstrated that women who receive EC before they need to use it («advance provision») are more likely to use it if unprotected intercourse occurs, there have been no trials in the United States evaluating the impact of pharmacy access on key reproductive health outcomes.4 - 6 Glasier and Baird demonstrated that Scottish women who had an advance supply of EC on hand were almost twice as likely to use the medication if needed; however, the sample size was small and the difference in pregnancy rates between access groups was not statistically significant, making it difficult to draw conclusions about the effect of advance provision on unintended pregnancy rates.7

While break - up strategies can provide significant financial benefits, the process should not be taken without careful consideration and advanced planning to ensure success.