• Genetic quality control monitoring
Whole genome scanning (rapid or more detailed) for routine strain background monitoring, or in case of suspected contamination error, is a quick, inexpensive and reliable method compared to physical, immunological and biochemical assays, traditionally used for genetic quality assessment.
• Mouse
whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic software.
Not exact matches
While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ
genome - wide association (GWA) analysis, which
scans an individual's
whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.
They have made possible wholesale
scans that turn up new gene modifications and variations, and the same should prove true for the new human gene arrays, says Joseph Ecker, a plant scientist at the Salk Institute for Biological Studies in La Jolla, California, who has helped pioneer
whole -
genome chips for Arabidopsis.
In addition to Affymetrix, another California company, Agilent Technologies Inc. of Palo Alto (a sponsor of ScienceNOW), has begun distributing its own human
genome array as an experimental prototype, and since June, NimbleGen Systems Inc. of Madison, Wisconsin, has been using yet another
whole -
genome setup to support a DNA -
scanning service at a lab in Iceland.
Whole -
genome scans will tell parents a story about a particular future for their child — a future that those parents may not be rooting for.
But because the fetus's sequences were inferred from their parents» gene
scans,
whole -
genome sequences of the parents (rather than a comparison with 900,000 points) are needed to get a complete fetal
genome, Lo says.
Researchers led by Kari Stefansson at deCODE genetics in Reykjavik
scanned whole -
genome data from 1795 Icelanders for variations in APP that protect against Alzheimer's.
Within this consortium, she has conducted
genome - wide association
scans for over 75,000 participants and has undertaken one of the first large - scale
whole -
genome sequencing studies for colorectal cancer, sequencing the
whole genomes of 2,000 patients with colorectal cancer and 1,000 healthy control participants.
Furthermore, by chromatin immunoprecipitation and
whole -
genome scanning approaches, we show that the chromosome ends of senescent cells directly contribute to the DNA damage response, and that uncapped telomeres directly associate with many, but not all, DNA damage response proteins.
Therefore, we have to
scan the
whole genome (all of the DNA) to find the defect.
A
whole -
genome scan in 164 Dutch sib pairs with attention - deficit / hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q