Sentences with phrase «wide association studies ashg»

The results of the present study suggest that the debate about the validity of cG × E (Duncan and Keller, 2011) and the preferred strategy of genome - wide association studies, rather than studies of candidate genes, merits nuance, as these designs are complementary.

Genetic research comprises formal genetic studies, candidate gene studies, linkage analyses, and recently large - scale genome wide association studies, gene - environement interaction studies, and pharmacogenetics.

While genome - wide association studies (GWAS) are an efficient approach for the identification of recessive alleles, they require several unrelated affected individuals [17]--[19].

Two genome - wide association studies were conducted to identify a genetic component within the Friesian horse breed that may cause CPL or predispose them to the condition.

In human populations, genome - wide association studies have revealed associations between variants of the circadian clock — related gene Mntr1b, which encodes melatonin receptor 1B, fasting glucose concentrations, and the risk of type 2 diabetes (12 — 14).

Given the large number of genome - wide association studies that have recently been performed, it is clear that genome - wide interaction testing will be the logical next step after single - locus testing.

Despite the significant insights gained from large - scale studies designed to interpret this instruction book, including HapMap, Encyclopedia of DNA Elements (ENCODE), and genome - wide association studies (GWAS), our knowledge of the human genome remains far from complete.

While FDR is a well - recognized approach in biology, one could also argue for using a family wise error rate (FWER), which has been the norm in recent large - scale, genome - wide association studies (GWAS).

Genome - wide association studies (GWAS) of common variants have successfully implicated more than 70 genomic regions in type 2 diabetes, revealing new biological pathways and potential drug targets.

Incorporation of data from BP genome ‐ wide association studies (GWAS) revealed four BP coexpression network modules (coEMs) that are enriched with eSNPs that demonstrate low P ‐ values in BP GWAS.

Genome - wide association studies use «genechip» technology to identify genetic variants (single gene polymorphisms or «SNPs») that could explain differences in health between individuals.

Here, Kiel and colleagues perform a meta - analysis of genome - wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

In our laboratory we study the relation between the genetic variation that were identified in genome - wide association studies (GWAS) or by whole exome / genome sequencing (WES / WGS) and the cardiac disease.

69/3: 00 Genome - wide association studies identify RAB38 and HS6ST1 associated with albuminuria in diabetes.

Mapping hundreds of genetic variants through genome wide association studies provided an opportunity to gain insights into the pathobiology of immune mediated diseases.

In addition, recent genome - wide association studies have identified several hundred common genetic variants — inherited changes in the DNA sequence of the human genome — that play a role in an individual's susceptibility to complex human illnesses such as heart disease, mental illnesses, cancer and diabetes.

The paper, «Meta - analysis of genome - wide association studies of asthma in ethnically diverse North American populations» by Dara Torgerson et al., will be published online July 31, 2011 by Nature Genetics.

Genome - wide association studies (GWAS) have detected association between variants in or near the Lysophospholipase - like 1 (LYPLAL1) locus and metabolic traits, including central obesity, fatty liver and waist - hip ratio.

Recent technological advances have enabled genome - wide association studies and emerging next - generation sequencing studies to begin to decipher the nature of the heritable contribution to traits and disease.

Genome - wide association studies, or GWAS, are a popular method used by geneticists to find genetic variants associated with elevated risk for a particular disease.

Using individual - level data from 335,464 participants in the UK Biobank and summary association results from seven large - scale genome wide association studies, we examined the effect of this nitric oxide signaling score on cardiometabolic and other diseases.

Information was extracted from a recent meta - analysis of five genome - wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed.

The results of this study suggest that high - resolution fine - mapping in large samples can convert many discoveries from genome - wide association studies into statistically convincing causal variants, providing a powerful substrate for experimental elucidation of disease mechanisms.

339/11: 30 A practical guide to drug discovery through phenome - wide association studies.

Genome - wide association studies have identified associations between body mass index and two loci near cell adhesion molecule 1 (CADM1) and cell adhesion molecule 2 (CADM2), which encode membrane proteins that mediate synaptic assembly.

Computational methods for identifying new risk loci, training risk prediction models, and fine - mapping causal variants from summary statistics of genome - wide association studies are playing an increasingly important role in the human genetics community.

This includes Genome - Wide Association Studies (GWAS) to identify genetic loci associated with insecticide resistance and population genetic studies to describe population sub-structuring.

This discovery approach greatly enhances the future potential of epistasis analysis for systems biology, and can complement genome - wide association studies as a means of formulating hypotheses for targeted experimental work.

220/2: 30 PolyTest: A novel method for joint analysis of genome - wide association studies and functional annotations.

Saturday, Oct. 21, 9:45 - 10:45 a.m., Room 220B, South Building Platform Session: Transcriptome - wide Association Studies Moderators: Hae Kyung Im, University of Chicago; and Alexander Gusev, Harvard University

Genome - wide association studies have identified 200 inflammatory bowel disease - associated loci, but few have been conclusively resolved to specific functional variants.

Genome - wide association studies (GWAS) have yielded thousands of reproducible genotype - phenotype associations.

These genes are usually found using genome wide association studies (GWAS) and GenoMEL is carrying out a very large study indeed.

ASHG 2008: Advancing Our Understanding of Genetic Disease: New Findings from Genome - Wide Association Studies ASHG Press Release - November 12, 2008

Again, putting aside questions about the accuracy or utility of this information, there is a lot of published scientific literature that is potentially relevant to people with a particular genotype (including genome - wide association studies as well as a lot of classical human genetic literature and other functional studies).

During the past few years, various novel statistical methods have been developed for fine - mapping with the use of summary statistics from genome - wide association studies (GWASs).

Researchers will use GTEx data to follow up on findings from genome - wide association studies and as a resource for the general study of gene expression networks.

With funding for over a decade from the NSF and the USDA, the Rice Diversity Project supports QTL mapping, Genome Wide Association Studies (GWAS), and gene discovery using a suite of open - source genetic, genomic and bioinformatic resources developed in the McCouch lab.

LD Score regression distinguishes confounding from polygenicity in genome - wide association studies.

Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than replication - based analysis for two - stage genome - wide association studies.

Such work has become increasingly important given the expansion of genome - wide association studies identifying genetic risk factors for common diseases and corresponding efforts to commercialize genetic testing using these markers.

Genome - wide association studies have revealed genomic regions associated with more than 200 diseases, including heart disease, diabetes and different types of cancer.

The NASP output can be used for genome - wide association studies (GWAS) to correlate the genotype and phenotype, and can also be used for phylogenomics, which allows for an understanding of the relatedness of microbial isolates across temporal and spatial scales.

The sequencing work for this project has been done at the Wellcome Trust Sanger Institute, and the next phase of work is to develop a detailed catalogue of variants and a reference panel of quality - controlled genotyping data that can be used for accurate imputation in genome - wide association studies of malaria and other diseases.

Common risk alleles are often detected by genome - wide association studies (GWAS) 1,2.

Sur I, Tuupanen S, Whitington T, Aaltonen LA, Taipale J. Lessons from Functional Analysis of Genome - Wide Association Studies.

Yet another primary interest is in the genetics of hearing and deafness disorders using mouse models of human deafness disorders and genome - wide association studies in age - related hearing impairment.

«We started with candidate gene studies, then moved to common variants and genome wide association studies, and then, most recently, leveraged exome sequencing, he said.

«What can genome - wide association studies tell us about the genetics of common disease?»

deCODE MI ™ The deCODE MI ™ test detects two SNPs located on chromosome 9p21, discovered by deCODE and which various genome - wide association studies have confirmed as the highest impact genetic risk factor for heart attack and coronary artery disease identified to date.