Sentences with phrase «with axonal»

Marsh - Armstrong, N., Oglesby, E., Buckingham, B., Horner, PJ., Soto, I. (2007) Molecular Changes in DBA / 2J Retinal Ganglion Cells Coinciding With Axonal Transport Dysfunction (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 5553).

Glial changes in the optic nerve correlate with axonal degeneration in a mouse glaucoma model.

A) Proteins that associated with axonal guidance and signaling were significantly enriched (p = 6 × 10 − 20) in the CSF proteomes for all pooled samples.

In these studies, we developed a method to simultaneously record the activity of multiple excitatory thalamic neurons (ETN) together with the axonal activity of inhibitory thalamic neurons (ITN) in the same brain volume.

In a final set of experiments, the researchers used necrostatin - 1 to treat mice with axonal damage and hind leg weakness, a telltale sign of axonal demise similar to the muscle weakness that occurs in the early stages of ALS in humans.

Not exact matches

Instead, the researchers found that dendritic, but not axonal, varicosities could be induced by prolonged treatment with glutamate, an excitatory neurotransmitter that is released from damaged axons.

Chen Gu and colleagues at The Ohio State University discovered that they could induce the formation of axonal varicosities in hippocampal neurons grown in the lab by «puffing» them with bursts of liquid from a small pipette.

Ice hockey players with sports - related concussion have elevations in the axonal injury biomarker total tau and the astroglial injury biomarker S - 100 calcium - binding protein B, according to a study published online March 13 in JAMA Neurology.

They found subtle evidence of axonal injury at the cellular level in six athletes who had not been diagnosed with concussion but sustained RHI during the normal course of play.

Even small defects in the genes that assemble tubulin are associated with serious developmental disorders, such as Kenny - Caffey syndrome and Giant Axonal Neuropathy.

Strikingly, the researchers noticed the same signs of axonal demise in spinal cord cells obtained from human patients with ALS.

«Given the effectiveness of inosine in promoting cortical plasticity, axonal sprouting, and dendritic branching, the present evidence of efficacy after cortical injury in a non-human primate, combined with a long history of safe use, indicates a need for clinical trials with inosine after cortical injury and spinal cord injury,» noted Dr. Moore.

Necrostatin - 1 not only restored the myelin sheath and stopped axonal damage but also prevented limb weakness in animals treated with it.

When pathologists perform autopsies on people with diffuse axonal injury, they see severed axons with swollen tips, just like what Smith sees in his experiments.

When it is experimentally prevented (either by severing the projecting axons, by treating them with the drug vinblastine, which blocks axonal transport, or by administering 6 - hydroxydopamine, which destroys the nerve endings), the innervating sympathetic neurons in the ganglion die off.

In conclusion, our findings suggest that microstimulation, with its anatomical precision, physiologic - level currents, and action via axonal projections, holds promise for modification of memory circuits and thus for the treatment of memory impairments in people suffering from neurological disorders.

Work in several laboratories has shown that the retrograde axonal transport of NGF follows its interaction with specific receptor sites on the nerve terminals of the newly established fibers.

The lethal effects of blocking the axonal transport of NGF can be completely overcome, however, by supplying the cell bodies with externally administered NGF.

The distribution and morphology of neurons and axonal endings (puncta) immunostained with antibodies to gamma - aminobutyric acid (GABA) and glycine (Gly) were analyzed in auditory brainstem, thalamic,

In my laboratory, we hypothesize that age - dependent neuronal death occurs partly in response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survival.

Aβ proteins, which build up to toxic levels in the brains of people with Alzheimer's disease, impair the axonal transport of these cargoes.

Del -1-deficiency was associated with increased EAE severity, accompanied by increased demyelination and axonal loss.

This was then subjected to initial testing for immunological efficacy in mThy1 - AS mice, which overexpress WT human AS under the murine Thy1 promoter, and which exhibit sensorimotor behavioral deficits, axonal AS pathology, and C - terminally - truncated AS aggregates with regional distribution similar to PD and PD dementia (PDD).

Radial axonal growth initiates with myelination, and is dependent upon the C terminus of neurofilament medium (NF - M).

Illustrative example of pathway analysis with respect to axonal guidance pathways.

The proband underwent two nerve biopsies which showed an axonal degeneration, myelin modifications, and intra-axonal mitochondria with distorted cristae.

Furthermore, CRF - induced phosphorylation of tau protein interferes with neuronal energetics as it impairs axonal transport of mitochondria.»

Preliminary analysis found that children from families living in poverty tended to have a smaller, less - developed hippocampus with fewer axonal connections with the PFC.. On further analysis, the authors determined that it wasn't poverty itself that was associated with a less - functional hippocampus.

i) The insured person is accepted for admission, on an in - patient basis, to a public hospital named in a Guideline with positive findings on a computerized axial tomography scan, a magnetic resonance imaging or any other medically recognized brain diagnostic technology indicating intracranial pathology that is a result of the accident, including, but not limited to intracranial contusions or haemorrhages, diffuse axonal injury, cerebral edema, midline shift or phneumocephaly.

... There is severe axonal shear injury with grade I, grade II and grade III lesions noted.

Diffuse axonal injuries are common traumatic brain injuries that occur when the head rapidly accelerates or decelerates, with the brain moving faster than the skull.