Sentences with phrase «ylopo as a single agent»

But they dealt with things that do not act as one and therefore do not feel or enjoy freedom as single agents.

In multiple preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapy.

This may explain why thymidine showed limited effectiveness as a single agent in clinical trials.

Research has previously shown that veliparib is effective in combination with chemotherapy, but little data was available to indicate whether veliparib was effective as a single agent.

«Our results suggest that this treatment as a single agent is effective for mTNBC,» Adams says.

Gad Berdugo, CEO of EpiVax Oncology, says that such therapeutic vaccines could be used in combination with checkpoint inhibitors or, potentially, as single agents.

A safe attenuated replicating virus to combat cancer as a single agent or in combination with other therapies.

Currently, researchers are studying arsenic trioxide, as a single agent or in combination with other medicines, for treating myelodysplastic syndromes.

As a single agent, ipilimumab is approved as a second - line treatment, as well as adjuvant therapy for patients with completely resected melanoma.

Pfizer initiated a Phase 1 clinical study for EOS200271 (NCT02764151) as a single agent in patients with malignant gliomas (brain cancer), an area of significant unmet need, based on brain penetration of the compound.

Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-cancer effects either as a single agent or in combination with other drugs in treatment of esophageal cancer, B - cell chronic lymphocytic leukemia, endometrial carcinoma, recurrent / metastatic squamous cell carcinoma and most relevantly, previously treated locally advanced or metastatic breast cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).

In fact, they stressed the fact of quercetin's effectiveness as a single agent against pancreatic cancer tumors, declaring: «Quercetin alone inhibited tumor growth to such an extent that it could not be further enhanced by the addition of gemcitabine.»

It appears to work best in combination with other seizure medications rather than as a sole therapy but many dogs are able to use it as a single agent.

The study aimed at evaluating the product's effectiveness as a single agent treatment for canine lymphoma.

As real estate salespeople, the success of your business, or business that you generate as a single agent, depends entirely on your personal habits.

While I've had a team for eight years now, the decision to form a team ultimately boiled down to the fact that teams are always outproducing those real estate professionals working as single agents.

When you hire Eric, you get Eric plus his Team of Professionals working for you for the same price as a single agent... Why would you want to fly coach if it cost the same as 1st class!

«Transaction broker» means a broker who provides limited representation to a buyer, a seller, or both, in a real estate transaction, but does not represent either in a fiduciary capacity or as a single agent.

A real estate licensee in this state may enter into a brokerage relationship as either a transaction broker or as a single agent with potential buyers and sellers.

Not exact matches

«We as an industry have eliminated all single - cause agents, so we've learned a lot, but it's become more mysterious.

Program sales were up in the quarter driven by the sale of a number of shows, including Grey's Anatomy, America's Funniest Home Videos and Marvel's Agents of S.H.I.E.L.D. Ad revenue at the ABC Network was down low single - digits, as lower news and daytime ratings were partially offset by higher rates.

«In our March survey of Chinese overseas property buyers, buyers ranked trustworthiness as the single most important factor in choosing an agent.

ChemPro can even scale its manufacturing processes to produce single purpose chemical products such as a degreasing agent it created exclusively for a specific machine used by the automotive industry.

It is a history, and it has functioned — as history tends to function — as a binding agent, melding disparate individuals together into a single people by giving them a common past.

Annenberg countered that comic content (such as cartoons) is indeed a highly effective form of conveying serious lessons; that when a new person or agent enters a scene a «single» violent episode becomes «multiple»; that a six - week analysis made by the researchers revealed the same general results as the one - week sample; and that the risk ratio validly takes into account the fear that potential victims (such as young women) have when viewing violent television.8.

Identifying targets earlier and speaking to players, agents and clubs as soon as possible, rather than waiting until the last minute, is certainly one way of improving a transfer policy that nearly left the Gunners without a single significant signing before the window closed.

He has plenty of people talking about him but his agent has already singled out Arsenal as the perfect club.

A single New York county outside of Albany — Rensselaer — participates in a program that deputizes local authorities as immigration agents — and now advocates are calling on Cuomo to prohibit the initiative statewide.

Although both schemes see religious or supernatural agents as imposing codes of moral conduct, BSP does not assume a single supreme deity who oversees that process.

Out of various options, the manufacturer chose blood clotting factor VIII octocog alfa as a comparator, but limited its selection to a single third - generation agent of octocog alfa (trade name: Advate).

The term state is in quotes, because a wide variety of agents — ranging from single atoms such as xenon to polycyclic hydrocarbons — can produce insensibility to pain and loss of awareness.

As networked control systems have grown increasingly large and complex, system designers have moved away from having system devices — or «agents» — coordinate their activities through a single, centralized computer hub, or brain.

Tuberculosis continues to be a global pandemic, second only to AIDS as the greatest single - agent killer in the world.

The research team has found that linking two or more different toxin - neutralizing VHHs results in VHH - based neutralizing agents (VNAs) that have extraordinary antitoxin potency and can be produced as a single molecule in bacteria at low cost.

It has recently surpassed HIV / AIDS as the greatest killer worldwide due to a single infectious agent.

A team of scientists from Whitehead Institute and the University of Texas Southwestern Medical Center has added markedly to the job description of prions as agents of change, identifying a prion capable of triggering a transition in yeast from its conventional single - celled form to a cooperative, multicellular structure.

The tumors formed in mice co-treated with chidamide and decitabine were significantly smaller than those that formed in untreated animals or those treated with the single agents, starting from 15 days of treatment (Figure 4C, left panel), as visualized by 18F - fluorodeoxyglucose small - animal positron emission tomography — computed tomography at 21 days of treatment (Figure 4C, right panel).

In the next several years, when the laboratory process for recreating micro tumors is fast and reliable, Dr. Simeone expects to offer a Phase 1 clinical trial to design tailored single and combination therapies, as well as experimental agents targeting specific mutations.

Second, prominent thought leaders — in this case, cancer doctors — read these early reports and offer up opinions that only add to the hype, overlooking the fact that the drug has never been proven to help when used by itself (known as «single - agent activity).

«This really established the combination therapy with a BRAF inhibitor as the standard, as opposed to single - agent therapy in patients who are candidates for these options,» said Salama.

These results serve as a rationale for ONC201 single - agent trials in relapsed / refractory acute leukemia, non-Hodgkin's lymphoma, MM and combination trial with dexamethasone in MM, provide pharmacodynamic biomarkers and identify further synergistic combinatorial regimens that can be explored in the clinic.

In order to detect whether an excess body burden of lead, cadmium, and other toxic metals is present, a challenge test should be performed with a single dose of a chelating agent such as EDTA or DMPS to see how much of the metal (s) can be pulled into the urine.

Although both scientists and lay people alike may frequently identify a single dietary element as the cause of chronic disease (eg, saturated fat causes heart disease and salt causes high blood pressure), evidence gleaned over the past 3 decades now indicates that virtually all so - called diseases of civilization have multifactorial dietary elements that underlie their etiology, along with other environmental agents and genetic susceptibility.

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Still, it's all so overwrought and difficult to settle into, as nearly every single character is given their own monologue about spiritual turmoil, right down to Ortiz's insurance man coming off like this angelic agent because each story he hears is «different» and thus life - altering in some way.

As satire, it can't touch any single episode of «Arli $ $,» the riotous (if profane) HBO series about an agent, which mercilessly skewers the world of sports on a regular basis.

There's an extended, perfectly calibrated cat and mouse encounter with a cagey, boy scout - faced FBI agent (Kyle Chandler) that adds some texture to this single - minded plot; there's Margot Robbie as Belfort's wife so blondly beautiful, it's hard to imagine men not expiring at the sight of her; and there's one early scene with Matthew McConaughey so kooky and venal, he's just got to walk away with the Oscar for best supporting actor.

The ensemble is really wonderful (pity that SAG didn't honor them) but I'd like to single out five: Kyle Chandler's visible bullshit - meter as an upstanding FBI agent is a special treat; Australian actress Margot Robbie's baby - talking sex doll who has one heel in DiCaprio's face, one hand in his wallet, and her other hand....

But they insist on that set - up because, as the exclusive bargaining agent, they then get to collect dues from every single worker.