Sentences with phrase «zebrafish as»

121/4: 00 Cbx3 and its role in craniofacial development: Zebrafish as a model system for testing dysmorphology candidate genes.

«Because of this functional conservation of lincRNAs between zebrafish and humans, we're introducing the zebrafish as a new vertebrate tool that could be used basically to uncover the functions of other lincRNAs,» says Shkumatava.

This RegMedNet Podcast talks to Sandra Rieger (MDI Biological Laboratory; Bar Harbor, ME, USA) about how the Rieger lab uses zebrafish as a model to study wound healing mechanisms and nerve regeneration in peripheral neuropathy.

In particular we are interested to unravel the mechanisms that ensure the maintenance of the apical membrane when exposed to physical stress, e. g. during morphogenesis of epithelial tissues, or when exposed to light stress in photoreceptor cells, using Drosophila and zebrafish as model organisms.

Before coming to Columbia she worked as a technician in Leonard Zon's lab at Harvard Medical School using zebrafish as a model for investigating the molecular mechanisms of hematopoietic stem cell differentiation and self renewal.

11:50 - 12:10 Per - Erik Olsson, Örebro University, School of Science and Technology Zebrafish as a model for endocrine disruption

The main focus is to understand how cell biology drives morphogenesis using vertebrate eye formation as a model and zebrafish as main experimental organism.

So desirable is the zebrafish as a scientific model that the National Institutes of Health recently launched the NIH Zebrafish Initiative Website, offering funding for studies of cancer, cardiovascular, blood and pulmonary diseases, eye development and disease, gene function, circadian rhythms, aging, longevity, immune system development and function, addiction, hearing, balance, smell and taste.

We aim to comprehensively annotate functional elements, decipher genomic codes of transcription, as well as coding and non-coding gene function during development and enhance zebrafish as an attractive developmental, comparative and disease model.

Tobin, who helped to develop the zebrafish as a model of TB, decided to use the system to study the blood vessels associated with granulomas.

Using zebrafish as a model system, the researchers exposed the fish embryos to seven different types of TAML activators.

This approach opens new avenues for research into memory using zebrafish as model organism,» concludes Dr. Okamoto.

OIST scientists selected the zebrafish as an animal model because its retina is rich in cones and its visual acuity can be measured with a simple device.

We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.

His lab is continuing to use the zebrafish as a model organism, but Junker also sees great potential in applying the technique to human organoids.

To solve such a complex puzzle, Jasmine McCammon, a postdoctoral researcher in Sive's lab, enlisted the zebrafish as a «living test tube.»

She commented: «Our previous research to validate zebrafish as a model for epilepsy put us in a good position to be able to help the EuroEPINOMICS consortium investigate the function of CHD2.

More recently, Godinho Ferreira, who now employs three Ph.D. students and four postdocs, has been working to establish Zebrafish as a new model system to try and understand the role of telomeres in aging and the role of telomere - elongation enzymes in cancer.

Not exact matches

COVER A three - dimensional micrograph of computationally separated cells with their internal organelles, as captured by a movie of the developing zebrafish eye.

Zebrafish that stop swimming when left without company are showing promise as the first fish model of a human mood disorder.

The centers exploit the core infrastructure of the chosen institutions, such as ARMI's zebrafish facility.

That allows her to image the cells of awake, moving creatures, such as the flashing neurons of crawling fly larvae or the beating hearts of twitching zebrafish, without the problem of blurring when the animal moves.

Baier plans to use larval stages but he admits it is not clear yet whether the larval zebrafish will react in the same way as the adult mutants.

Forthcoming workshops cover techniques as varied as «molecular and genetic tools for the analysis of medaka and zebrafish development» and «cryo - electron microscopy and 3 - D image reconstruction.»

So Farber and Quinlivan and their team were actually able to see the fats that they fed their zebrafish glowing under the microscope as they were broken down and reassembled into new molecules in different organs.

«Thus, we hypothesize that Gdf3 combines with Ndr1 and Ndr2 to facilitate Nodal signaling during zebrafish development, acting as an essential factor in embryonic patterning,» said Pelliccia, a graduate student in molecular biology.

In the study, Burdine and two graduate students Jose Pelliccia and Granton Jindal used CRISPR / Cas9 gene editing to remove Vg1, known as Gdf3 in zebrafish.

Unlike humans, zebrafish larvae are transparent, which allowed researchers to watch their brains as they slept.

In contrast to mammals, the elimination process is delayed as a result of the accumulation of cocaine in zebrafish eyes: 50 % of the cocaine was eliminated after eight hours in clean water, and 30 % still remained after 48 hours.

«Like zebrafish, we have this rich source of gut microbes that have figured out how to coexist with us and soothe the immune system,» she says, adding that «there is enormous potential to harness those mechanisms» to address ailments such as inflammatory bowel disease and other chronic inflammation.

To gain more insights as to why zebrafish are more successful at regenerating spinal tissue, the researchers analyzed the gene expression of fish spinal tissue following injury, identifying seven genes of interest.

These fundamental discoveries were made in non-human organisms such as the algae, Chlamydomonas reinhardtii, and the zebrafish, Danio rerio.

«But the zebrafish heart robustly regenerates missing or damaged tissue in as little as 30 to 60 days.

Salamanders and newts take this approach to heal and rebuild a severed limb, as do zebrafish to mend clipped fins.

The protein itself has been known to researchers for some time as a result of research on zebrafish, where it plays an important role in the healing process following damage to the spinal cord.

«Using models such as zebrafish and neonatal mice that regenerate their hearts naturally, we can begin to identify important molecules that enhance heart repair,» said Ellen Lien, PhD, of The Saban Research Institute of Children's Hospital Los Angeles.

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes — fam57ba and doc2a — in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity.

For this reason, the zebrafish is now used as a model organism by scientists around the globe.

As a next step, Dr. Reimer's research team intend to analyse the effect of different drugs on zebrafish OPCs in order to potentially identify a method to improve functional spinal cord repair in humans.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

Based on analyses of scales from highly relevant species for aquaculture such as common carp (Cyprinus carpio), gilthead sea bream (Sparus aurata), sea bass (Dicentrarchus labrax), Mozambique tilapia (Oreochromis mossambicus), Atlantic salmon (Salmo salar), rainbow trout (Oncorhynchus mykiss) and pike perch (Stizostedion lucioperca) as well as from fish commonly used in experimental studies such as zebrafish (Danio rerio), it was found that glucocorticoids, especially cortisol, incorporate in fish scales over time.

National Institutes of Health researchers studying zebrafish have determined that a population of cells that protect the brain against diseases and harmful substances are not immune cells, as had previously been thought, but instead likely arise from the lining of the circulatory system.

In addition to fruit flies, they successfully used the program to analyze images of zebrafish and mice, as well as data collected from a commercial light sheet microscope and a commercial confocal microscope.

In the current study, the researchers showed that FGPs are present on the surface of the zebrafish brain and that these blood vessel - associated FGPs do not arise from the immune system, as had been previously thought, but from endothelial cells themselves.

Zebrafish have emerged as an important vertebrate model for cardiovascular research for a number of reasons, including the ability to regenerate its heart if damaged, and because the transparency of the embryos allows easy observation of internal processes like blood vessel development.

These studies demonstrate that inflammatory intestinal pathologies, such as Hirschsprung - associated enterocolitis or inflammatory bowel disease, can be explained as an overgrowth of certain pro-inflammatory groups of bacteria or a loss of anti-inflammatory bacteria, said Judith Eisen, a professor of biology and an expert on gut neurons in zebrafish.

Building on traditional SIM technology, the iSIM allows real - time, 3 - D super resolution imaging of small, rapidly moving structures — such as individual blood cells moving through a live zebrafish embryo.

Thus, it came as a surprise that it is Abcb4 that in zebrafish acts as «multidrug» or «multixenobiotic» trans - porter.

Zebrafish (Danio rerio) embryos illustrating the function of the transporter protein Abcb4 acting as effective chemical defense by keeping out chemical compounds from the embryos.

According to Monk and Ackerman, possible future work includes using the zebrafish model system as a drug - screening tool to search for small molecules that may flip that switch.