Sentences with phrase «zika rna»

The authors emphasize that clinicians should continue to consider testing for Zika RNA when a definitive diagnosis has not been reached.

(A) Standard curve for Zika virus RNA transcript dilution series showing the threshold cycles Ct plotted against the log10 of Zika RNA transcripts and (B) Standard curve obtained with 10-fold serial dilutions of Zika virus.

They then used a portable isothermal amplification device — which could be used for point - of - care testing — to identify Zika RNA.

Other important findings in the Nature Medicine article include: • Zika RNA was detected in blood plasma as early as one day after Zika virus infection.

Although the CDC recommends that men exposed to Zika wait at least six months before having sex without condoms, researchers found that, for most men in the study, Zika RNA disappeared from semen by 81 days.

In 95 percent of participants, Zika RNA was no longer detectable in urine after 39 days, and in blood after 54 days, researchers report February 14 in the New England Journal of Medicine.

In 95 percent of men tested, Zika RNA disappears from semen by 81 days.

In 95 percent of people tested, Zika RNA is cleared from the blood by 54 days after symptoms begin, and urine by 39 days.

albopictus mosquitoes that hatched tested positive for Zika RNA (ribonucleic acid), meaning that females collected in the field had encountered Zika and passed fragments of the virus to their offspring.

«It is important to test all mosquitoes collected in areas with a high number of Zika cases for Zika RNA, and if the mosquitoes are positive for Zika RNA they must be tested for live Zika virus prior to transport or use in a laboratory for experiments.»

«Detecting Zika RNA fragments without finding live Zika virus suggests that either the female parent was not itself infected with live Zika virus or it was not able to transfer live Zika virus to her eggs,» Smartt says.

• Zika RNA was detected in blood plasma as early as one day after Zika virus infection.

• During early and late states of infection, Zika RNA was detected in tissues, including the brain and male and female reproductive tissues.

• Zika RNA cleared from blood plasma and urine within 10 days, but viral RNA was detectable in saliva and seminal fluids until at least three weeks after Zika virus was no longer present in the blood.

Not exact matches

Zika, dengue and chikungunya (which are also found in Colombia) are RNA viruses, which refers to how they encode their genetic material, and each is transmitted by a specific mosquito called Aedes aegypti.

Chotiwan et al. describe a loop - mediated amplification (LAMP) assay that detects Zika virus RNA in human biofluids such as serum and semen as well as in mosquitoes, the insect vector that transmits the disease.

So they have solved the structure of the Zika virus helicase bound to a strand of its genomic RNA as well, which identifies a tunnel running through the whole enzyme to hold the viral RNA.

A rapid, specific, sensitive, and inexpensive method has been developed that detects RNA from a Zika virus strain associated with the current outbreak.

The scientists were most surprised by the fact that the Zika virus helicase undergoes significant conformational change when encountering its genomic RNA.

Peersen's group seeks to understand the complex biochemical replication machinery of positive - sense single - stranded RNA viruses, a group that includes coxsackievirus, poliovirus, dengue and Zika.

The paper reports that 306 of the affected babies were tested for Zika virus infection with the ultrasensitive polymerase chain reaction that detects viral RNA or immune markers.

There also are questions about how much spread occurs without a mosquito vector: Zika can persist in semen and be transmitted sexually, and there's an outside chance that viral RNA in saliva, which never has been linked to an infection, might pose a risk.

In a recent test of Asian tiger mosquitoes collected in Brazil, researchers found fragments of Zika virus RNA, raising concerns that it may be carried by species other than Zika's known primary vector, the yellow fever mosquito.

«RNA interference is activated in human response to influenza, other important viruses: Discovery could lead to better ways of combating serious infections, including Ebola and Zika.»

By contrast, the new Zika candidate vaccine uses tiny strands of RNA that hold the genetic codes for making viral proteins.

«In the future we hope to apply this strategy to target other disease - causing RNAs, which range from incurable cancers to important viral pathogens such as Zika and Ebola,» added Research Associate Sai Pradeep Velagapudi, the first author of the study and a member of the Disney lab.

«We are trying to fill the knowledge gap between the infection and potential neurological defects,» says first author Hengli Tang, the team's virologist whose lab studies RNA viruses like Zika, Dengue, and hepatitis C virus.

TRACES OF ZIKA Zika virus RNA lingers in bodily fluids for different lengths of time.

ZIKA PEEK Inside an immature Zika virus (interior shown at right), the protein and RNA core (dark blue) contacts the inner layer of the viral membrane (aqua, see arrows).

If that is the case, the intranasal RNA therapy could theoretically be developed for treatment of other mosquito - borne diseases, such as St. Louis encephalitis, Japanese encephalitis, and perhaps Zika, the researchers noted.

Dengue virus and Zika virus are both positive - strand RNA flaviviruses, which means that once a virus particle infects a cell, its RNA genome can be immediately translated by cellular machinery into viral proteins to make new virus particles and spread the infection.

However, how reliably do these tests detect the Zika virus, i.e. do they also detect viral RNA in very low virus concentrations?

«Chemical tags affect ability of RNA viruses to infect cells: Similar controls found in Hepatitis, Zika, Dengue, Yellow Fever.»

If the sample contains the RNA of the Zika virus, the test area turns purple.

Because Zika has a similar RNA polymerase, a number of labs have been looking at Sovaldi's possible impact on the virus.

Placenta and fetal heads from the placebo cohort showed high levels of viral RNA levels while corresponding tissues in mice immunized with Moderna's Zika mRNA vaccine showed marked virological protection (placenta, 200-fold mean reduction; fetal head, 13,000-fold mean reduction).

10 of 19 (53 %) placentas and 11 of 19 (58 %) fetal heads from mice who received Moderna's Zika mRNA vaccine had viral RNA levels at the limit of detection of the assay, suggesting virtually complete protection, and the remainder had substantially lower levels than those detected in samples from mice in the placebo cohort.

In addition, vaccinated mice had significantly lower levels of Zika virus RNA in maternal, placental and fetal tissues compared to placebo - injected mice, resulting in protection against damage to the placenta and fetus.

CAMBRIDGE, Mass., July 13, 2017 — Moderna Therapeutics, a clinical stage biotechnology company that is pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, today announced new data demonstrating that its Zika mRNA vaccine prevented Zika virus transmission from pregnant mice to their fetuses.

A drop of the boosted RNA to the paper discs - which are freeze - dried and contain different cells and proteins - will change color to signify a positive Zika virus.

For this project, they presented a color - changing technology that could detect Ebola virus by embedding a sensor to screen for particular RNA sequences, which can represent the presence of Ebola and other viruses such as Zika and measles.

In order to test this discovery, the study co-authors spiked Zika - or dengue - infested samples with fluorescent reporter RNAs.

They then scanned multiple RNA sequences from the sample, and used genetic databases to help them decide which candidate sequence would be best suited for its purpose as a broad Zika reference.

Testing for Zika virus RNA in placental tissue can confirm Zika infection when the mother's blood tests are inconclusive, according to a new study.

They have identified specific small RNAs from Zika virus that could impact brain development and lead to microcephaly, at least in mice.

The researchers observed changes in human small RNAs produced in hNPCs upon Zika infection, as well as in small RNAs directly generated from Zika virus.

Among other things, human tears potentially could be tested for viral RNA or antibodies, which would offer a less painful way to diagnose Zika infection than drawing blood.