For instance, the way
Zika infects human cells and hijacks their machinery to copy itself many times has proved elusive.
In a study published Tuesday, lead author and professor of medicine Dr. Michael Diamond explained that by infecting these manipulated mice, the researchers were able to mimic how
Zika infects humans.
Not exact matches
The
Zika virus is most commonly transmitted in
humans as the result of a bite from an
infected mosquito or from an
infected human to another
human.
Using
human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the
Zika virus changes the properties of neural stem cells in the developing brain of an
infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).
Benzoquinoline was also effective against vesicular stomatitis virus from the rhabdovirus family, which can
infect insects, cattle, horses and pigs, and
Zika virus, which is spread to
humans by mosquitoes.
Human placental cell line Jeg - 3 can be readily
infected by a circulating strain of
Zika virus (left panel) and completely protected by treatment with nanchangmycin (right panel).
Confocal microscopy of
human neural stem cell culture
infected with
Zika virus (red).
The team can not yet say if similar signaling happens in
human fetuses
infected with
Zika.
The two reports also showed that
Zika virus
infected and damaged neuronal stem cells harvested from mice and
humans.
Pregnant mice were
infected with
Zika virus early in pregnancy (corresponding to mid — first trimester in
humans).
The researchers tested that idea by
infecting newborn mice (which developmentally resemble a
human fetus) with different lab - made versions of
Zika.
That's consistent with earlier in vitro findings that
Zika can
infect and damage
human neural precursor cells.
O'Connor points out that
Zika -
infected monkeys do not perfectly reflect
humans, either, and he sees the various models as complementary.
It's very unlikely that she was
infected by a bite by a mosquito that first bit her husband; the three tropical Aedes mosquito species known to transmit
Zika don't live in northern Colorado, and moreover, the virus has to complete a 2 - week life cycle within the insect before it can
infect the next
human; Foy's wife fell ill just 9 days after his return.
Pregnant mice were
infected vaginally with
Zika at one of two times — one corresponding to mid first trimester in
humans, the other to late first trimester.
Monkeys are naturally
infected with
Zika virus and are far closer to
humans in many ways, and at least a half - dozen studies are underway.
Scientists are currently testing the bacterium as a potential foil against the master vector — the Aedes aegypti mosquitoes — that
infect humans with dengue fever,
Zika among other diseases.
The multinational research group utilized a model system where
human retinal pigment epithelial cells were
infected with
Zika virus strain they isolated earlier from fetal brain [T1].
«It appears that pregnant women
infected with
Zika can pass the virus to babies in utero and that newborns also may be susceptible to infection,» said Diamond, also an associate director of the university's Center for
Human Immunology and Immunotherapy Programs.
Like 80 % of
humans infected with the
Zika virus, most of the non-human primates used in this study lacked any apparent clinical symptoms.
Garcez and her colleagues at the Instituto D'Or in Rio de Janeiro in Brazil are starting experiments in which they will
infect so - called cerebral organoids — tiny models of the developing
human brain — with
Zika virus and see whether their development is affected.
* Update, 7 December, 11:30 a.m.: This item has been updated to indicate that although
Zika has been shown to
infect mice, it is not clear whether it would have similar effects on pregnant animals as it may in
humans.
Previous research conducted recently in Brazil and elsewhere points to increased mortality rates for
human neural progenitor cells (hNPCs)
infected by
Zika virus, as well as growth inhibition and morphological abnormalities.
«What we show is that the
Zika virus
infects neuronal cells in dish that are counterparts to those that form the cortex during
human brain development.»
Despite vaccines and efforts to eradicate the pesky insects, they continue to
infect humans with feared diseases like
Zika virus, malaria and West Nile virus.
«
Zika virus
infects human neural stem cells.»
The approach enabled a wide range of studies of
human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the
human brain and identifying how the mosquito - borne
Zika virus may contribute to microcephaly in infants
infected in utero.
VIRUS VICTORY
Zika virus (green)
infects and kills stem cells (red) in
human glioblastoma tissue, without
infecting healthy brain cells.
«Mosquitoes could
infect humans with
Zika and chikungunya viruses at the same time: Second study links three mosquito - borne viruses —
Zika, chikungunya and dengue — currently hitting Americas to severe neurological problems.»
In tests using
human neural progenitor cells (NPCs)-- self - renewing, multipotent cells that generate neurons and other brain cell types — the scientists found that exposure to sofosbuvir not only rescued dying NPCs
infected with the
Zika virus, but restored gene expression linked to their antiviral response.
Mosquitoes are capable of carrying
Zika and chikungunya viruses simultaneously and can secrete enough in their saliva to potentially
infect humans with both viruses in a single bite, according to new research presented today at the 2016 Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH).
Strengthening the link between
Zika virus and microcephaly, scientists at UC San Francisco have discovered that a protein the virus uses to
infect skin cells and cause a rash is present also in stem cells of the developing
human brain and retina.
Concord, NH — The New Hampshire Department of Health and
Human Services (DHHS) is announcing the first confirmed case of a New Hampshire resident
infected with
Zika virus.
«However, these new findings strongly suggest that testes function in
human men
infected with
Zika should be closely investigated so that we can try and establish whether or not
Zika poses a new threat to male reproductive function.»
To determine whether the
Zika virus caused this, a number of independent teams of researchers — including two in Brazil and one at the University of California, San Diego — created brain organoids from healthy
human cells and
infected some of them with the
Zika virus.
«It certainly doesn't take much for a virus that is perfectly adapted to
infect humans to spread provided the conditions are ideal — and in the case of
Zika it found a population that had never seen the virus before and so had no immunity to it, and also a bountiful supply of the insect that it needs to spread.
The Dallas County Health and
Human Services Department said that an unidentified patient had become
infected with the
Zika virus after having sex with an individual who had returned from Venezuela, one of the Latin American countries where
Zika is circulating.
One study from Indonesia performed in the 1970's found that the virus could
infect livestock and bats but there are no documented cases of any of these animals transmitting
Zika virus to
humans.