Science's picks for Areas to watch in 2017 are human embryo research,
Zika vaccine trials, the search for Planet Nine, and the impacts on research of the U.S. election and «Brexit» vote.
Not exact matches
Then if there is a
Zika outbreak in its area, a centre would be ready to begin a
vaccine trial straight away.
A phase I clinical
trial for a
Zika vaccine which began in August 2016 in partnership with the Wistar Institute and Inovio / GeneOne Pharmaceuticals aims to discover the safety and effectiveness of a DNA
vaccine for
Zika.
By some estimates one in 5,000
Zika patients develops GBS, but the question of whether the
vaccine — which would contain some viral DNA if not the whole virus — will also cause this rare side effect will not be adequately answered in small
trials that contain less than 100 volunteers.
Three
vaccine approaches have been shown to protect monkeys against
Zika infection, and human
trials began in July.
The ZPIV
vaccine candidate was developed by WRAIR as part of the US Department of Defense response to the 2015 - 2016 outbreak of
Zika virus in the Americas, and it was advanced to a Phase 1
trial in November 2016.
Healthy adults mounted strong immune responses after receiving an investigational whole inactivated
Zika virus
vaccine, according to interim analyses of three Phase 1, placebo - controlled, double - blind
trials conducted at Beth Israel Deaconess Medical Center (BIDMC), Walter Reed Army Institute of Research (WRAIR), and Saint Louis University School of Medicine.
«We observed rapid and durable protective immunity without adverse events, and so we think this candidate
vaccine represents a promising strategy for the global fight against
Zika virus,» said senior author Drew Weissman, MD, PhD, a professor of Infectious Disease at Penn. «We hope to start clinical
trials in 12 to 18 months.»
Ferguson's team is calling for
trials of
Zika treatments and
vaccines to be designed so that even if the epidemic burns out, they are ready to kick in quickly should
Zika roar back again.
Candidate
Zika vaccines, which have shown early promise, should be in clinical
trials next year.
If new money does not surface soon, Fauci warned that human
trials of
Zika vaccines might be delayed.
«The rapid advancement of
Zika vaccine candidates into clinical
trials reflects the uniquely focused and effective collaboration among scientists in the field to address this important global problem,» said Barouch.
Nelson Michael of the Walter Reed Army Institute of Research in Silver Spring, Maryland, says that the
trial Zika vaccine will be tested on mice and monkeys that already have antibodies to dengue, to see if that interferes with the
vaccine.
PHILADELPHIA --(April 19, 2018)-- The Wistar Institute and partners at the Perelman School of Medicine at the University of Pennsylvania, Inovio Pharmaceuticals, and GeneOne Life Science were recognized among the Top 10 Clinical Research Achievement Awards by the Clinical Research Forum for their ground - breaking phase 1 DNA - based
Zika vaccine research — the first
trial of a
Zika vaccine in humans, which proved safe and effective.
In just the last 6 years the EID outbreaks of MERS, Ebola,
Zika, CHIKV as examples have underscored the importance of rapid
vaccine development and deployment capabilities to meet EID challenges, as well as growing appreciation for creativity and flexibility in clinical
trial design.
The Walter Reed Army Institute of Research (WRAIR) began vaccinations today in a Phase 1 human clinical
trial to test the safety and immunogenicity of the
Zika purified inactivated virus (ZPIV)
vaccine.
[NIH officials accelerate timeline for human
trials of
Zika vaccine, saying they will now begin in the summer]
A study published in Nature reports the results of
trials of two potential
vaccines against the
Zika virus in mice.
«But, overall, this report illustrates well the current rapid pace of
Zika vaccine development and one US company (Inovio) reported recently plans to start a
trial of their DNA
vaccine technology for
Zika very soon.»
Recently at Wistar, Muthumani was one of the creators of a
Zika vaccine that was the first to enter clinical
trial.
More than a dozen experimental clinical therapies and
vaccines have been developed from research from the Weiner laboratory, including the first
Zika vaccine in clinical
trials, as well as a novel immunotherapy for HPV - associated cancer and precancer.
The study, published in the August issue of the journal Science Communication, examines what happened in August 2016 after the launch of the first human
trial of a
Zika vaccine.
Last Wednesday, U.S. health officials announced that a potential
vaccine for the
Zika virus had entered early clinical
trials to assess its safety in humans.
In other news, research on a potential
vaccine for the
Zika virus entered early clinical
trials last week.
Meanwhile, the Obama administration said last week that it will transfer $ 81 million from existing federal health programs so there's enough money to continue
trials of a
Zika vaccine.
On Monday, the National Institutes of Health (NIH) announced the launch of the first of five clinical
trials in humans to test the safety and effectiveness of a
Zika vaccine.