While
zonisamide also decreased both UPDRS Part II (off - time) and UPDRS total scores compared to placebo (UPDRS Part II [off - time] scores: WMD, — 0.79; UPDRS total scores: WMD, — 2.51), there were no significant differences in other secondary outcomes between the two groups.
Zonisamide — this is a sulfa - class medication that is used as a second or third - line treatment, however, it can
also be used as a first - line therapy.