Sentences with phrase «aberrant activity»
In addition to being integral to cell biology, tyrosine kinases also present targets for new anticancer therapies: One of the most highly touted, rationally designed anticancer compounds, Gleevec, inhibits an oncogenic tyrosine kinase whose aberrant activity fuels the rampant growth of cells in patients with chronic myeloid leukemia.
https://www.the-scientist.com/
With hair - thin electrodes, it is now possible to put a pump on the side of them and deliver drugs to the site when there is aberrant activity, quiet it down.
Not exact matches
Needless to say our more mechanistic colleagues regarded these as somewhat aberrant, if not bizarre, activities!
FGFRs work in an aberrant manner in 10 - 15 % of HER - 2 negative breast cancers, which could explain a greater the compound's greater anti- tumour activity compared to other compounds.
Electronic monitors now in development could mold to the brain's surface to sense aberrant electrical activity.
«More importantly, these findings encourage the search for personalized music - based interventions for the treatment of brain disorders associated with aberrant dopaminergic neurotransmission as well as abnormal mood and emotion - related brain activity.»
They found that by elevating the activity of PV - GPe neurons over the activity of the Lhx6 - GPe neurons, they were able to stop aberrant neuronal behavior in the basal ganglia and restore movement in the mouse model for at least four hours — significantly longer than current treatments.
Discovered that mouse models of AD (APP mice) develop aberrant patterns of neuronal network activity, including network hypersynchrony, epileptiform activity, and seizures.
Discovered that aberrant patterns of neuronal network activity result in profound anatomical and physiological alterations of learning and memory centers and may contribute to cognitive deficits in humans with AD and related mouse models.
Dr. Palop discovered that mice genetically engineered to simulate AD (hAPP mice) develop aberrant excitatory patterns of neuronal network activity, including network hypersynchrony, epileptiform activity, and seizures.
Aberrant intrinsic brain activity and cognitive deficit in first - episode treatment - naive patients with schizophrenia.
These observations raise the possibility that aberrant neuronal activity in AD is a primary upstream mechanism of cognitive dysfunction.
A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.
University of Washington School of Medicine Therapeutic inhibition of aberrant protease activity in inherited neutropenias
Our data yield novel insight in the organization of neuronal ensemble activity consisting of excitatory and inhibitory cells, provide basic, experimental data for computational neuroscience and will allows the investigation of the pathomechanisms underlying aberrant thalamocortical oscillations which characterizes all major neurological diseases.
Targeted drugs bind and shut down the activity of aberrant proteins - products of specific mutations.
Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically.
Mice lacking this protein developed an autoimmune disease as a result of aberrant T cell activity and over-inflammation.
The generation of double - strand DNA breaks as a result of aberrant AID activity is strongly implicated in the genesis of MYC / IG translocations (Robbiani et al., 2008; Dorsett et al., 2007).
She also had to worry that any telomerase activity she saw was an aberrant result caused by one of the DNA polymerases that replicate the middle of the chromosomes.
For example in individuals with reactive aggression aberrant amygdala activity but intact amygdala structure is observed [151].