Sentences with phrase «aberrant cells»

It is literally defined as «self eating,» because when the body has no other fuel, it feeds its cells and does cleanup work by metabolizing cancerous growths, and breaking down yeasts, mold, fungi, viral, bacterial, and many other aberrant cells and growths.

Longo's research culling epidemiological studies, as well as centenarian studies and his own research with various populations, points to not just the «self - eating» phenomenon of autophagy burning out aberrant cells first (not muscle mass, my friends, not unless that muscle needed replacing)--

Vibrational + Contains astragalus root, a powerful adaptogenic herb that heightens immune system responses and lengthens telomeres in healthy cells, * but not in aberrant cells.

Furthermore, when injected into live animals, these aberrant cells form tumors.

Cancerous tumors are composed of clonal cells — genetically aberrant cells that derive from a single wayward ancestor.

In addition to being the first line of defense against pathogenic attack, the immune system seeks out aberrant cells within the body that may become cancerous.

In this rewriting of the textbooks, a tumor is not just a clump of aberrant cells; it also includes a support system, a tumor microenvironment, which encompasses a multitude of varying immune cell types and crisscrossing chemical signals, along with a network of blood vessels.

The act of reprogramming cells to make them as capable as ones from embryos apparently can result in aberrant cells that age and die abnormally, suggesting there is a long way to go to prove such cells are really like embryonic stem cells and can find use in therapies.

A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.

Not exact matches

CRAC channels are found on many cell types, including immune cells and pancreatic acinar cells, where aberrant activation of these channels is thought to play a key role in the pathobiology of acute pancreatitis.

Engineers are well - equipped to sketch so - called wiring diagrams of biochemical pathways that lead to aberrant cancer cells.

Rapidly dividing, yet aberrant stem cells are a major source of cancer.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

Though scientists have managed to come up with drugs that target and turn off aberrant BRAF signaling, cancer cells are clever.

HeLa cells are so biologically aberrant in their chromosome makeup that they could never be used to model immortal human life, but they nevertheless point the way.

Several factors newly discovered to be phosphorylated by GSK - 3 are also known to be mutated in acute myeloid leukemia, a condition in which aberrant splicing causes uncontrolled white blood cell proliferation.

The current finding, Gladfelter says, «helps us understand how the right components get recruited to droplets so cells can potentially avoid this transition to an aberrant, solid state.»

Cancer cells, although aberrant in many respects, are still influenced by their cellular milieu.

The aberrant and ongoing activation of ERVs caused an accumulation of retroviral proteins in the affected cells and deregulation of genes and pathways.

The experiments reveal that the sudden loss of energy supply to the heart cells and the subsequent rapid «reboot» during treatment causes mitochondria to falter and trigger a whirlwind of aberrant electrical signals.

In asthma this aberrant immune response leads to immune cells infiltrating the lungs, where they cause inflammation that affects lung function and leads to difficulties in breathing.

«Our organotypic models demonstrate the power of the microenvironment by showing that normal cells in their native architecture naturally steer fully malignant, genotypically aberrant tumor cells into a quiescent state,» Ghajar says.

The mutated gene, FAA, codes for an aberrant, as - yet - unnamed protein that initiates a cascade of malfunctions in various body systems, including production of blood cells and platelets in the bone marrow.

EPFL scientists have found that chronic inflammation can cause regenerating cells to grow into new, aberrant types; this is called metaplasia, and is a disorder linked to prolonged inflammation.

Just as youthful stem cells use telomerase to offset telomere length loss, cancer cells employ telomerase to maintain their aberrant and destructive growth.

What's more, mice with the selective deletion of MHCII in ILCs also developed inflammatory bowel disease, which was driven by aberrant CD4 + T - cell responses to commensal bacteria.

If Rbfox1 proteins are lost and mRNA is no longer repressed, that could lead to aberrant growth of cells, or cancers.

In the current paper, knowing that MYC, a transcription factor that binds the genome through sites that are identical to the binding sites of BMAL1, the team hypothesized that aberrant MYC expression perturbs the clock by deregulating components of the circadian network in cancer cells.

«For a cell, aberrant activation of autophagy could easily have lethal consequences.»

Star - shaped brain cells known as astrocytes aid perform many indispensible functions, but a new study shows that an aberrant version of the cells may contribute to many neurodegenerative diseases.

Blood founder cells showed a much lower propensity for aberrant methylation than did other founder cells, which could explain why in the past scientists attributed the founder cell to the effectiveness of differentiating iPS cells to the hematopoietic lineage.

A better understanding of aberrant brain receptor signaling that leads to nerve cell dysfunction could reveal a target for therapy, according to the authors.

The ability to dispose of proteins that are either aberrant or (in the worst case) toxic is fundamental to a cell's survival.

«The advances in transplant techniques and the range of available cell sources that can be used to optimize the treatment of aberrant corneal wound healing can give reassurance to patients with corneal injuries that preserving vision may be possible in the near future,» wrote the authors of the Stem Cells review.

Cancer cells that have a relatively large number of mutations in their DNA express aberrant proteins — or neoantigens — that reveal the cancer to the immune system.

The class of compounds that includes GDC - 0449 could also help contain other cancers, such as ovarian and colorectal cancers, that are not triggered in the same way as medulloblastoma or basal cell carcinoma but that are still partly driven by aberrant Hedgehog signaling.

Transformed cells such as the Jurkat line may show aberrant DNA methylation patterns at specific loci [57], possibly complicating analyses of cytosine methylation and HIV - 1 latency.

We have discovered that in normal cells, the aberrant replication origins are subsequently eliminated.

Furthermore, high - resolution analysis of cytosine methylation in primary and transformed cells has found less aberrant methylation of CpG island promoters in transformed cells than had been previously hypothesized based on candidate gene studies [58].

This aberrant 2 - AG signaling reduces inhibitory GABAergic signaling at ventral tegmental area dopaminergic synapses, resulting in enhanced dopamine cell excitability and excessive dopaminergic responses to nicotine.

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

Xu and her colleagues could duplicate those effects with his cardiac muscle cells in culture, by observing the ability of the drugs to suppress aberrant «calcium sparks.»

Scientists investigating the mechanisms of Down Syndrome (DS) have revealed the earliest developmental changes in embryonic stem cells caused by an extra copy of human chromosome 21 — the aberrant inheritance of which results in the condition.

In addition to being integral to cell biology, tyrosine kinases also present targets for new anticancer therapies: One of the most highly touted, rationally designed anticancer compounds, Gleevec, inhibits an oncogenic tyrosine kinase whose aberrant activity fuels the rampant growth of cells in patients with chronic myeloid leukemia.

Aberrant regulation of planar cell polarity in polycystic kidney disease.

This result was similar to recently published data from the Egli lab in New York, which used an alternative technique, that of maternal spindle transfer or MST in eggs prior to fertilization, where they also had one aberrant ES cell line where this occurred (out of 8).

Anaplastic lymphoma kinase (ALK)-- positive anaplastic large cell lymphoma (ALCL) frequently carries the t (2; 5)(p23; q35) resulting in aberrant expression of chimeric nucleophosmin - ALK.

Intractable diseases, disorders, and injuries are characterized by cell death or aberrant cellular function.

of aberrant amyloid and tau in the retina, quantification of any neuronal degeneration, delineation of cellular stress responses of neurons and particularly glial cells, and investigation of oxidative stress.