Sentences with phrase «aberrant expression»

Within some (small) circles of debate this may be true (or is this pointing to the aberrant expression of the minority climate change debate in the USA?)

However, it may also be an aberrant expression of the predatory behavior that is, if you will, hijacked by the laser movement.»

A possible explanation for this finding is that residual mRNA expression from oocytes was still present in morula stage parthenotes and / or chemical activation induced the aberrant expression of certain genes in parthenotes.

However, we can not suspect any abnormal effect on parthenotes due to the aberrant expression of CCNA1 since the protein is not expressed at the blastocyst stage [33], and its cell cycle regulation role is limited in meiotic cells [34].

Defective BRCA1 causes aberrant expression of non-coding satellite RNA that leads to genomic instability, thereby promoting cancer development.

Anaplastic lymphoma kinase (ALK)-- positive anaplastic large cell lymphoma (ALCL) frequently carries the t (2; 5)(p23; q35) resulting in aberrant expression of chimeric nucleophosmin - ALK.

Until now the mechanism by which the aberrant expression of glutamate receptor 1 in melanocytes leads to oncogenesis remains unknown.

Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy.

On the other hand, aberrant expression of miR - 7 was observed in glioblastomas, and it has been characterized as a putative tumor suppressor by targeting EGFR and AKT (23, 24).

With these tools, Verma is revealing how the aberrant expression of normal cellular genes can causes tumors.

Section of a stomach cancer (seen under a microscope) showing aberrant expression of YBX1 protein (stained brown).

«What is exciting about this study is that it goes beyond correlation and shows causation, because we demonstrated for the first time that aberrant expression of this protein is sufficient to induce pathology.»

This work provides a proof of principle for a new approach in the study and treatment of cancer: the aberrant expression in a tissue or organ of genes specific to other tissues could become a new tool for establishing a prognosis and personalizing therapeutic care.

From a more fundamental viewpoint, the researchers still need to explain the relationship between the aberrant expression of these genes and the virulence of the cancer.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

Not exact matches

Their aberrant behavior challenged the daily ritual which had been an expression of faithfulness for generations.

In the third trial of the nurse home visitor program, nurse - visited, 6 - month - old infants born to mothers with low psychological resources (i.e., maternal IQ, mental health, and sense of efficacy) displayed fewer aberrant emotional expressions (e.g., low levels of affect and lack of social referencing of mother) associated with child maltreatment.18

In the current paper, knowing that MYC, a transcription factor that binds the genome through sites that are identical to the binding sites of BMAL1, the team hypothesized that aberrant MYC expression perturbs the clock by deregulating components of the circadian network in cancer cells.

Publication: Loss of NF - κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT -1-Dependent Manner.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

In cancers, aberrant promoter CpG island hypermethylation correlates highly with gene inactivation and can account for lack of gene expression where mutations do not exist.

Sovak MA, Bellas RE, Kim DW, et al: Aberrant nuclear factor - kappaB / Rel expression and the pathogenesis of breast cancer.

In the third trial of the nurse home visitor program, nurse - visited, 6 - month - old infants born to mothers with low psychological resources (i.e., maternal IQ, mental health, and sense of efficacy) displayed fewer aberrant emotional expressions (e.g., low levels of affect and lack of social referencing of mother) associated with child maltreatment.18