Sentences with phrase «aberrant genes»

29) Chari R, Coe BP, Vucic EA, Lockwood WW, Lam WW (2010) An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer.

It is a genetic disease caused when a child carries two copies of an aberrant gene — one copy from each parent.

Not exact matches

That's not to say gene editing is new (it isn't), but Crispr simplifies the process by using molecular scissors that can be precisely targeted to snip out aberrant regions of genetic code, which can then be replaced with the correct sequences.

There's the challenge of CRISPR» ing an unprecedented number of genes without compromising the viability of the designer pigs and without introducing aberrant edits.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

From a more fundamental viewpoint, the researchers still need to explain the relationship between the aberrant expression of these genes and the virulence of the cancer.

The scientists have shown that, in all cancers, an aberrant activation of numerous genes specific to other tissues occurs.

This work provides a proof of principle for a new approach in the study and treatment of cancer: the aberrant expression in a tissue or organ of genes specific to other tissues could become a new tool for establishing a prognosis and personalizing therapeutic care.

The researchers bred together mice that each carried one normal copy of the gene and one aberrant copy — that is, they were heterozygous.

The aberrant and ongoing activation of ERVs caused an accumulation of retroviral proteins in the affected cells and deregulation of genes and pathways.

In cancers, both gene mutations and aberrant regulation of genes (promoter inhibition by methylation of DNA) are known to play pivotal roles regulating cancer growth.

The mutated gene, FAA, codes for an aberrant, as - yet - unnamed protein that initiates a cascade of malfunctions in various body systems, including production of blood cells and platelets in the bone marrow.

Some researchers have conjectured, however, that the normal WS protein quashes formation of aberrant DNA structures in humans, a process that might go awry when the gene suffers a mutation.

This is an example of normal genes put together in an aberrant situation.

With these tools, Verma is revealing how the aberrant expression of normal cellular genes can causes tumors.

Furthermore, high - resolution analysis of cytosine methylation in primary and transformed cells has found less aberrant methylation of CpG island promoters in transformed cells than had been previously hypothesized based on candidate gene studies [58].

Targeted disruption of IRF - 1 or IRF - 2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.

The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure, suggesting an aberrant skin barrier as a potential risk factor for atopic dermatitis.

lentiviral vectors contain a deletion in the 3» LTR that prevents aberrant activation of nearby genes.

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

Additionally, alterations of subcellular localization through aberrant splicing or genetic mutations also provide ways to inactivate tumor suppressor genes (50).

This is believed to be true given the results of previous RNA - seq experiments (1, 4, 5) along with a belief that the odds are very low that Cas9 would have an off - target that lands in the promoter of another gene, thereby driving aberrant transcription.

A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

A possible explanation for this finding is that residual mRNA expression from oocytes was still present in morula stage parthenotes and / or chemical activation induced the aberrant expression of certain genes in parthenotes.

Aberrant beta - catenin - TCF target gene activation plays a major role in colorectal cancer development.

A recurring theme is the overlap of these core «multicellularity» genes with genes perturbed in cancer, a disease of aberrant multicellularity (see oncogenes and tumour suppressors in Figs 2 and 3).

Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»

«The data show that aberrant epigenetic gene programming can now be considered a hallmark of acute lymphoblastic leukemia, occurring in all patients regardless of the presence of genetic mutations,» Melnick said.

In cancers, aberrant promoter CpG island hypermethylation correlates highly with gene inactivation and can account for lack of gene expression where mutations do not exist.