Sentences with phrase «aberrant insulin»

CRAN reduces mitochondrial ROS production, lessening aberrant insulin signaling (and thus inhibition of FOXO1 and SIRT1), and promotes mitochondrial renewal via autophagy.28 Preliminary research indicates that even moderate CRAN (a reduction in caloric intake of just 8 % rather than the traditional 30 - 40 %) may promote muscle mitochondrial biogenesis in middle - aged human subjects and may therefore both delay onset and mitigate progression of sacropenia in older adults.29 30 31

But in older individuals in whom basal levels of oxidative stress are already increased, aberrant insulin signaling during the fasting state that militates against mitophagy and further decreases glutathione stores, becomes the final straw.

Bottomline: aberrant insulin signaling that inhibits autophagy, particularly mitophagy, is the first cause of death.

Wulf Dröge has proposed an alternate, much more optimistic, explanation: the shift from a homeostasis of repair to one of snowballing damage is due to the age - related onset of aberrant insulin signaling, which prevents autophagic recycling.15 16 17 18

Not exact matches

With age, ROS - induced aberrant triggering of the insulin signaling mechanism in the postabsorptive state inhibits autophagy, preventing maintenance of plasma cysteine and intracellular glutathione levels throughout the night and early morning hours, and initiating a vicious cycle of progressively increasing oxidative stress and mitochondrial dysfunction.