Sentences with phrase «aberrant pathways»

«This gives us a target to work on,» Young said at a press conference in New York this morning, alluding to the possibility that this basic research discovery may lead to a possible way to intervene in the aberrant pathway and fix it, enabling people who suffer from the condition to adhere to a normal sleep schedule without the need for sleeping pills.

Not exact matches

Engineers are well - equipped to sketch so - called wiring diagrams of biochemical pathways that lead to aberrant cancer cells.

«We identified the cytosolic protein Vms1 as a key component of a novel pathway termed mitoRQC that protects mitochondria from the toxic effects of such aberrant proteins,» explain the authors of the study.

The aberrant and ongoing activation of ERVs caused an accumulation of retroviral proteins in the affected cells and deregulation of genes and pathways.

The current approach provides a novel and unique, non-invasive strategy that aims to modulate and correct the aberrant neural pathways that cause tinnitus.

One possibility has emerged in the last decade: inhibitors of the Hedgehog pathway, whose aberrant activation drives growth in medulloblastoma.

Such changes are reflective of corticostriatal pathway degeneration and MSN hyper - excitability and are likely to result in aberrant striatal output.

We are applying an interdisciplinary approach to study the consequences of aberrant activation of the cAMP / CREB / CRTC signal circuit on these adaptive responses and how cooperative signaling with other pathways promotes oncogenic processes in oral, head, and neck cancers.

A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Novel treatments for cancer depend on the ability to modulate aberrant cellular pathways and effectively deliver therapeutics to the tumor.

29) Chari R, Coe BP, Vucic EA, Lockwood WW, Lam WW (2010) An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer.

This study shows for the first time proteins interacting with Nbeal2 and points to the dysregulation of the canonical signaling pathway of Dock7 as a possible cause of the aberrant formation of platelets in GPS cases and Nbeal2 deficient mice.

My laboratory aims to identify, characterize and validate lncRNA - driven pathways active in allergy - driving helper T cells and airway epithelial cells that could hold promise as therapeutic targets in altering the aberrant immune responses underlying asthma.

According to Benoit, one recently identified pathway to disorganized attachment is children's exposure to specific forms of aberrant caregiving behaviours that are referred to as «atypical.»