Sentences with phrase «aberrant proteins»

Targeted drugs bind and shut down the activity of aberrant proteins - products of specific mutations.

Mutations in a deubiquitinating enzyme of S. cerevisiae, which arose during the evolution of an aneuploid isolate, leads to improved proliferation of many aneuploid strains, likely by promoting degradation of aberrant proteins produced in perturbed stoichiometric ratios [11].

Studies have shown that magnetic resonance imaging, positron - emission tomography and spinal taps — and newer methods now in the lab — can detect the effects of the buildup of aberrant proteins characteristic of Alzheimer's some 10 to 15 years before the first symptoms appear.

Cancer cells that have a relatively large number of mutations in their DNA express aberrant proteins — or neoantigens — that reveal the cancer to the immune system.

«We expected that we might get aberrant proteins,» Simms said.

«We identified the cytosolic protein Vms1 as a key component of a novel pathway termed mitoRQC that protects mitochondria from the toxic effects of such aberrant proteins,» explain the authors of the study.

Either way, a drug that replaces the aberrant protein might counteract an otherwise devastating condition.

For the new study, O'Rourke and his colleagues designed a CAR targeting an aberrant protein called EGFRvIII that is present in roughly 30 % of glioblastomas and is thought to promote malignancy.

Not exact matches

Those anecdotes are often dismissed as aberrant behaviors — opportunistic protein snacks added to a diet made mostly of salad.

University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba with the Departments of Neurobiology & Behavior and Psychiatry & Human Behavior and their colleagues from UCI and from Children's Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

The aberrant and ongoing activation of ERVs caused an accumulation of retroviral proteins in the affected cells and deregulation of genes and pathways.

The mutated gene, FAA, codes for an aberrant, as - yet - unnamed protein that initiates a cascade of malfunctions in various body systems, including production of blood cells and platelets in the bone marrow.

He said the next step is to study how we can prevent these aberrant SNO reactions on particular proteins like PINK1.

Both unfolded proteins and aberrant membrane lipid compositions are sensed by Ire1 and can activate the so - called unfolded protein response.

The post-synaptic density is a specialized area full of proteins needed for communication between neurons, so changes in its structure or capacity may explain the aberrant electrical responses.

If Rbfox1 proteins are lost and mRNA is no longer repressed, that could lead to aberrant growth of cells, or cancers.

Some researchers have conjectured, however, that the normal WS protein quashes formation of aberrant DNA structures in humans, a process that might go awry when the gene suffers a mutation.

«What is exciting about this study is that it goes beyond correlation and shows causation, because we demonstrated for the first time that aberrant expression of this protein is sufficient to induce pathology.»

Section of a stomach cancer (seen under a microscope) showing aberrant expression of YBX1 protein (stained brown).

The ability to dispose of proteins that are either aberrant or (in the worst case) toxic is fundamental to a cell's survival.

Defective mRNAs will result in aberrant, potentially harmful proteins; an efficient process for recognizing and disposing of such mRNAs is therefore essential.

The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure, suggesting an aberrant skin barrier as a potential risk factor for atopic dermatitis.

«It may be that the normal TEL allele successfully suppresses the function of the aberrant TEL - AML1 protein resulting from the fusion, so full - blown leukemia doesn't occur,» said the lead author of the study, Joseph Wiemels, PhD, now a UCSF assistant research molecular epidemiologist.

The results of her project will help scientists develop novel therapies to target the regulatory proteins that cause CD47 overproduction in leukemia and other cancer stem cells, with the goal of restoring immunosurveillance and enabling the immune system to recognize and destroy these aberrant cancer cells.

However, we can not suspect any abnormal effect on parthenotes due to the aberrant expression of CCNA1 since the protein is not expressed at the blastocyst stage [33], and its cell cycle regulation role is limited in meiotic cells [34].

Recent work in fragile X syndrome suggests aberrant fronto - striatal and fronto - parietal networks and relates these abnormalities «forward» to behavior and «backward» to decreased protein expression.As the field of neuroimaging has matured, it has revealed its promise as a safe, reliable, in - vivo tool in the study of developmental disorders.

Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).

Mice lacking this protein developed an autoimmune disease as a result of aberrant T cell activity and over-inflammation.

This study shows for the first time proteins interacting with Nbeal2 and points to the dysregulation of the canonical signaling pathway of Dock7 as a possible cause of the aberrant formation of platelets in GPS cases and Nbeal2 deficient mice.

«On the other hand, neurofibrillary tangles are composed of aberrant tau proteins.