Sentences with word «abl»

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

(B) Model for the role of ABL kinases in the regulation of breast cancer bone metastasis.

Here, we uncovered a critical role for ABL kinases in the regulation of breast cancer metastasis to bone.

To directly examine whether ABL kinases regulate tumor - induced osteoclast activation, we used an in vitro osteoclastogenesis assay (Fig. 5A).

Translocation results in an oncogenic BCR - ABL gene fusion that can be found on the shorter derivative 22 chromosome.

This gene encodes for a Bcr - abl fusion protein.

(B) Survival of mice after intracardiac injection of 1833 (1 × 105) breast cancer cells and treatment with either dimethyl sulfoxide (DMSO) control or the allosteric ABL inhibitor GNF5.

This gives a school full, unlimited access to Abl Master Scheduler, ongoing upgrades throughout the year, and personalized support.

ABF Journal spoke with Haddad and Sterling Specialty Lending Division President Ted Geisel about the impact the merger will have on the unit and their outlook on ABL lending in 2016.

The team at Abl understands how difficult this work can be, and has developed an intuitive platform that allows us to easily evaluate master scheduling options to best support student course needs, avoid scheduling conflicts, and create more time for teacher planning.»

Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage - independent growth and survival

The first out ABL lenders sought full payment for contingent indemnification claims and certain expenses as a condition to a credit bid by Standard General, its counterparty under the 2013 credit agreement AAL.

To directly evaluate the relationship between ABL family kinases and metastasis, we analyzed ABL1 and ABL2 protein abundance in MDA - MB - 231 — derived breast cancer cell lines with different organ metastasis tropisms (19).

ABL provides financing solutions that typical lenders can not.

The fused BCR - Abl protein interacts with the interleukin - 3 receptor beta (c) subunit.

Decreased metastasis by ABL - deficient breast cancer cells was accompanied by a significant reduction in the extent of hindlimb osteolytic lesions, as determined by x-ray and micro — computed tomography (μCT) imaging (Fig. 2, I and J).

At the time of filing, the obligations under this facility were owed to a variety of funds referred to as the «first out ABL lenders» as well as to Standard General acting as last out lender under the 2013 credit agreement.

An interview with two leaders from Abl, a new San Francisco - based venture seeking to help schools rethink how they use time.

Its regional brands — such as ABL Management, Aladdin, A'viands, Cura, STARR Catering and Valley Services — have operational autonomy in their local regions and markets and receive overall corporate support for finance, purchasing, sales and marketing and human resources.

Dr Richard Byers, who jointly led the research, said: «Previous studies have linked high levels of the BCR - ABL mutation with drug resistance.

BCR / ABL expression of myeloid progenitors increases beta1 - integrin mediated adhesion to stromal cells.

To test the theory, Arlinghaus and colleagues first demonstrated that BCR - ABL positive cells expressed 24p3 and secreted it into the surrounding tissue, causing cell death.

Similarly, inhibiting ABL kinase activity with the allosteric inhibitor GNF5 decreased TAZ protein abundance (fig.

The initiative focuses on small retail outlets that have the widest consumer reach within ABL's distribution network, and are a...

In order to make trading a little easier and hopefully less stressful, I have developed the EminiScalp ABL AutoTrade Strategy.

Our EminiScalp ABL AutoTrade Strategy is designed to assess a variety of trading factors when price reaches these areas.

In analyzing the asset - based lending market at the dawn of a new year, David Gaito, SVP and regional sales manager of PNC Business Credit, notes three significant factors: 2012 was not as bad as advertised, a supply / demand imbalance remains and ABL potential in 2013 is mixed.

«Over a year of collaboration with schools nationwide, we've learned firsthand what a complex and frustrating process master scheduling can be for school leaders,» said Abl Founder, Adam Pisoni.

To support acquisition by Fred's of 865 Rite Aid stores, Bank of America, Merrill Lynch and Regions Capital have provided $ 1.05 billion of committed ABL financing.

«I think M&A is going to continue at a solid pace, but its impact on ABL demand does depend on which industries it is happening in,» reminds Philbrick.

In an ABF Journal interview, three active participants share their outlook on the current state of ABL capital markets.

In less than a year as CEO, Poplin has seen nearly a 50 percent growth in revenue thanks to strong organic growth and three recent acquisitions: STARR Catering, Cura and ABL Management.

ABL Co. said Hayashi had worked with the firm but declined to comment on his claims.

Double knockdown of ABL1 and ABL2 was required to decrease the phosphorylation of CrkL by more than 90 %, which indicates inactivation of the endogenous ABL kinases (Fig. 2K).

RH: How did you wind up focusing Abl on this whole question of how schools use time and how administrators organize instruction?

«The master schedule is, in many ways, the blueprint of a school — but a Rubik's Cube of programs, people, and events can make the scheduling process overwhelming and time - consuming for school leaders,» said Abl Founder and CEO Adam Pisoni, who previously served as CTO and Co-Founder of Yammer.

To support its pioneering efforts to simplify the master scheduling process, education technology startup Abl today announced $ 7.5 million in Series A funding, led by Rethink Education.

In addition, ABL offers competitive New Construction loans to experienced investors.

«The Staples acquisition of Office Depot is a good example on M&A driving ABL demand.

«Banks continue to flow into ABL, and smaller banks are creating groups.

Make checks payable to ABL Services or pay online.

Contributing editor Howard Brod Brownstein talks to five leading ABL capital markets players about market conditions now that the official end of the downturn is four years behind us.