As applied to the Initiative, the enhanced sensitivity of the laser
ablation measurement approach will be harnessed for measuring stable isotope content of nanogram amounts of RNA samples.
Not exact matches
These include custom - built light sheet microscopy for single molecule and whole embryo
measurements, laser
ablation to perturb and dissect the architecture of microtubule structures, quantitative polarization microscopy, and new fluorescence correlation spectroscopy
approaches.
Experimental
approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser
ablation for cortex tension
measurements, AFM).