Sentences with phrase «abnormal accumulation of»

A surprising number of cats have problems with constipation (abnormal accumulation of feces and difficulty defecating), and similar but more serious conditions such as obstipation (complete obstruction of the colon by feces) and megacolon (damaged nerves and muscles in the colon causing an inability to defecate).

Anything that results in an abnormal accumulation of material in the ear canal often can not get out due to the canal pointing upward and thus inhibiting drainage.

Edema is an abnormal accumulation of fluid in the cavities and intercellular spaces of the body.

Foul breath because of the abnormal accumulation of nitrogenous wastes in the blood unable to be eliminated because of kidney failure

Known as bloat, distended abdomen is an abnormal accumulation of fluid in the abdomen.

For liver disorders associated with abnormal accumulation of copper, the amount of ingested copper must be minimized.

The exact mechanisms leading to the abnormal accumulation of air in respiratory tissues are not well understood.

Emphysema is the abnormal accumulation of air inside an organ or tissue.

Patients with hydrocephalus have abnormal accumulation of cerebrospinal fluid (CSF) in the ventricles, or cavities, of the brain.

This defect impairs the breakdown of complex molecules resulting in abnormal accumulation of this macromolecules in the cells of the peripheral and central nervous system.

This can lead to an abnormal accumulation of excessive copper in the liver known as copper storage hepatopathy, leading to hepatic dysfunction and scarring (cirrhosis).

This condition is caused by abnormal accumulation of air in the stomach.

Anasarca: a condition where neonatal puppies have an abnormal accumulation of fluids in their tissues.

Hydrocephalus: a condition where there is an abnormal accumulation of fluid in the ventricles of the brain.

Hepatic lipidosis: an abnormal accumulation of lipids in the liver which leads to liver failure.

Since the major culprit in diabetes is the abnormal accumulation of glucose in the blood, a canine diabetic diet is centered on reducing the carbohydrate content of food.

Bloat (dilation) is a condition of an abnormal accumulation of air, fluid, and / or foam in the stomach and can occur with or without the twisting (volvulus) of the stomach.

Edema is an abnormal accumulation of fluid in a body part.

Congestion, an abnormal accumulation of blood, in the lower extremities is no good thing.

Abnormal accumulation of aluminum has been found in the brains of people with Alzheimer's disease, and when aluminum is injected into the brains of laboratory animals, the animals develop a neurological disease similar to Alzheimer's.

Past research has shown that Parkinson's patients with LRRK2 mutations often show an abnormal accumulation of alpha - synuclein as well.

However, it is widely accepted that a central event in AD pathogenesis is the abnormal accumulation of Aβ and its related toxins, either due to increased production or to deficits in clearance mechanisms [52, 53].

(3,18; cf. 19,20) Even in visceral fat, it has recently emerged that the obesity - driven rise in inflammation and insulin resistance is associated with an abnormal accumulation of senescent cells, albeit senescent endothelial cells rather than adipocytes.

A group of disorders that includes both Alzheimer's and FTD, tauopathies are characterized by the abnormal accumulation of the protein Tau in neurons.

Crigler - Najjar Syndrome is a rare genetic liver disease (incidence around 1/1 000 000 births) associated with the abnormal accumulation of bilirubin — a yellow pigment produced by the liver — in all the body's tissues, particularly the brain tissues.

Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red) in glioblastoma stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.

Abnormal accumulation of PPIX is known to lead to EPP.

Other approaches target the abnormal accumulation of the protein tau in neurofibrillary tangles.

Aside from the feat of answering the longstanding question of how the lymph system arises, understanding how it forms and develops can provide important insights into disease, from metastasis to the abnormal accumulation of lymph fluids, particularly in the wake of surgery to remove cancerous tumors.

In the current study, Dr. Santambrogio and her colleagues looked for abnormal accumulations of proteins in the synovial fluid (which bathes the joints) and blood of patients with JIA.

Share Pei fever can also lead to Amyloidosis, an enzyme deficiency results in abnormal accumulations of amyloid proteins, causing liver or kidney failure.

Not exact matches

LM22A - 4 treatment reduced the accumulation of abnormal proteins in the striatum and cortex — brain regions affected in Huntington's disease.

Also, the study is the first to reveal that microRNAs (miRNAs) influence the development of lipodystrophy (abnormal fat accumulation) which affects many people with HIV receiving anti-retroviral therapy.

It may also bring about advances in diagnosing diseases like Alzheimer's and multiple sclerosis, both of which involve abnormal iron accumulation in the brain.

Amyloid — an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer's disease — starts accumulating inside neurons of people as young as 20, a much younger age than scientists ever imagined, reports a surprising new Northwestern Medicine study.

Amyloid — an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer's disease — starts accumulating inside neurons of people as young as 20, a much younger age than scientists ever imagined.

The problem with making blood stem cells proliferate outside the body is that the artificial growth gives rise to an accumulation of abnormal proteins in a part of the cell called the endoplasmic reticulum, ER.

«How nerve cells are damaged by accumulation of abnormal proteins.»

Both types of dementia (memory and language) can be caused by an accumulation of beta - amyloid, an abnormal toxic protein in the brain.

Several human neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's disease but also aging, are linked to an accumulation of abnormal and aggregated proteins in cells.

«Our results indicate that exercise may slow the progression of Parkinson's disease by turning on the protective gene DJ - 1 and thereby preventing abnormal protein accumulation in brain,» Freed said.

Lewy bodies (accumulation of abnormal alpha - synuclein A protein in the human brain that is associated with the development of Parkinson's.

Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of plaques (composed of amyloid - beta protein) and fibrous tangles (composed of abnormal tau) in brain cells called neurons.

NAFLD is an imbalance between the uptake and removal of lipids in hepatocytes, which leads to abnormal triglyceride accumulation, or steatosis.

This manipulation, which they had previously found to prevent abnormal brain activity, also prevented the excessive accumulation of DSBs.

(21) Moreover, while the link between excessive visceral adipose tissue and age - independent diabetes and metabolic syndrome widely known, recent studies suggest instead that it is the accumulation of senescent subcutaneous adipocyte progenitors — and their abnormal metabolic function — that drives similar diabetes - like phenotypes during the «normal» aging process.

We report here that in vitro generated DS neural cells have abnormal metabolism of amyloid - β (Aβ) manifested by increased secretion and accumulation of Aβ granules of Aβ42 pathological isoform with upregulated expression of the APP gene.

The relatively small number of such cells in a youthful tissue is so small as to be harmless, but after decades of accumulation, the number becomes large enough that their abnormal metabolic state begins to pose a threat to surrounding, healthy tissues.

Alzheimer's Disease involves the accumulation of abnormal protein — either amyloid beta or Tau protein which gums up the brain system.

The accumulation of stress adversely affects the brain, impairing metabolism, and causing abnormal blood sugar and insulin levels, leading to carbohydrate cravings.