Sentences with phrase «abnormal blood vessels in»

One class of drugs, called vascular endothelial growth factor inhibitors, for example, is designed to thwart the growth of abnormal blood vessels in the eye.

We were very excited to find that our compound, at fairly low doses, could quite significantly block the formation of abnormal blood vessels in this model.

Summary: Use of eye injections of drugs aimed at slowing the growth of abnormal blood vessels in the eye is becoming more common for the treatment of individuals with many eye problems including macular degeneration, diabetic retinopathy and retinal artery or vein blockage.

Pulmonary hypertension develops because of abnormal blood vessels in the lungs, which makes it harder for the heart to push blood through and provide oxygen to the rest of the body.

However, a recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

Not exact matches

When there is an increase in blood circulation at the time of pregnancy, the blood vessels may branch outwards and appear abnormal.

Two protein molecules that fit together as lock and key seem to promote the abnormal formation of blood vessels in joints affected by rheumatoid arthritis, according to researchers at the University of Illinois at Chicago College of Medicine, who found that the substances are present at higher levels in the joints of patients affected by the disease.

ROP involves an abnormal growth of blood vessels in the retina that may lead to scarring, retinal detachment and, in severe cases, blindness.

In humans, abnormal and excessive blood vessel growth related to decreased oxygen supply is the most common cause of blindness in premature babies, diabetics, and the elderlIn humans, abnormal and excessive blood vessel growth related to decreased oxygen supply is the most common cause of blindness in premature babies, diabetics, and the elderlin premature babies, diabetics, and the elderly.

Although such abnormal tau clusters are found in brain diseases including Alzheimer's, their location in CTE is unique — near small blood vessels, and most often near the bottom of sulci, the deep folds in the brain's cortex.

Earlier research by other scientists has shown that the drug verteporfin, used to treat abnormal blood vessel formation in the eye, acts on the YAP pathway inhibiting the protein's YAP function.

In the U.S., one in every four deaths is a result of heart disease, which includes a range of conditions from arrhythmias, or abnormal heart rhythms, to defects, as well as blood vessel diseases, more commonly known as cardiovascular diseaseIn the U.S., one in every four deaths is a result of heart disease, which includes a range of conditions from arrhythmias, or abnormal heart rhythms, to defects, as well as blood vessel diseases, more commonly known as cardiovascular diseasein every four deaths is a result of heart disease, which includes a range of conditions from arrhythmias, or abnormal heart rhythms, to defects, as well as blood vessel diseases, more commonly known as cardiovascular diseases.

The gene MAP2K1 has previously been linked to some types of cancerous growths as well as to conditions that lead to abnormal blood vessel formation in the head, face or neck.

In sickle cell anemia, a single genetic mutation leads to abnormal, crescent - shaped red blood cells that clot in tiny blood vessels throughout the body, causing severe pain and eventual organ damagIn sickle cell anemia, a single genetic mutation leads to abnormal, crescent - shaped red blood cells that clot in tiny blood vessels throughout the body, causing severe pain and eventual organ damagin tiny blood vessels throughout the body, causing severe pain and eventual organ damage.

ROP is a condition that causes abnormal blood vessels to grow in the retina (back of the eye) and can cause retinal detachment, which is a major cause of childhood blindness globally.

The researchers used computed tomography (CT) scans to evaluate the severity of abnormal calcium deposition in one of the largest blood vessels in human body, the abdominal aorta.

Linda Shavit, MD (University College London Medical School, in the UK, and Shaare Zedek Medical Center, in Israel) and her colleagues wondered whether the heart problems experienced by kidney stone formers might be due to abnormal deposits of calcium in their blood vessels.

It's thought that the high pressure observed in tumors is a result of these abnormal blood vessels, which leak fluid and proteins into the area between tumor cells, known as the interstitial space.

AMD is described in stages — early, intermediate, and late — with vision loss occurring in late - stage AMD, either from atrophy or abnormal new blood vessels.

Roughly 20 percent of patients with age - related macular degeneration suffer from abnormal blood vessel growth and vascular leakage, says Campochiaro, and so may be helped by this new therapy, if it proves to work in clinical trials.

Working with mice, a multicenter team of researchers has found a new way to reduce the abnormal blood vessel growth and leakage in the eye that accompany some eye diseases.

A problem in this research arena — called antiangiogenesis — has been finding a compound that is selective, closing off abnormal blood vessels only in the diseased organ while leaving all others intact.

Brodsky was part of a team that developed the modified Ham test that measures levels of components of serum,, a protein - rich liquid in blood, and showed it was effective in diagnosing atypical hemolytic - uremic syndrome (aHUS), a genetic disorder in which abnormal blood clots form in small blood vessels in the kidneys.

In AMD, the retinal pigment epithelial (RPE) cells that support the cells in the eye that detect light wear out, and there is also the growth of abnormal, leaky blood vessels below the retinIn AMD, the retinal pigment epithelial (RPE) cells that support the cells in the eye that detect light wear out, and there is also the growth of abnormal, leaky blood vessels below the retinin the eye that detect light wear out, and there is also the growth of abnormal, leaky blood vessels below the retina.

«Finding a way to control angiogenesis not only provides a target for the development of anti-cancer therapies, but may also prove useful in similarly starving abnormal blood vessel growth elsewhere in the body, like in diabetic eye disease.»

The scientists also have demonstrated in animals that the PKal molecular pathway can induce retinal edema through mechanisms that are independent of the VEGF pathway, which at normal levels helps to build and maintain blood vessels but at high concentrations can induce abnormal vessel growth and contribute to DME.

(Revlimid) An immunomodulatory and anti-angiogenic agent, this drug slows the growth of blood vessels feeding abnormal cells and kills abnormal cells in the bone marrow.

These abnormal cells — in the case of pulmonary hypertension, those that line the blood vessels leading to the lungs — release signals that stimulate the growth of small new blood vessels to feed the renegade cells, allowing further proliferation, and thickening of the vessel walls.

In the less common wet AMD, something (scientists aren't sure what) spurs abnormal blood vessel growth, and central vision can be lost in a matter of weeks or dayIn the less common wet AMD, something (scientists aren't sure what) spurs abnormal blood vessel growth, and central vision can be lost in a matter of weeks or dayin a matter of weeks or days.

We really wanted to find a compound, a chemical, that would profoundly stop the growth of blood vessel cells, which of course are the cells that go on to form the abnormal angiogenesis in wet AMD.

The concept of tailoring drugs to regulate and treat abnormal brain blood vessels is a novel treatment strategy and offers great potential to complement existing treatments of this debilitating disease,» commented Dr Matthew Campbell, assistant professor in neurovascular genetics at TCD.

That was the research niche that we set out to explore to see if we could find a new way of targeting the abnormal blood vessel growth that occurs in wet AMD.

Because, of course, it is this abnormal proliferation of blood vessel cells, which we term angiogenesis, in the back of the eye that is the key feature of wet AMD.

«Instead of treating patients after these abnormal blood vessels form in the eye, we may be able to give patients eye drops or systemic medications that prevent their development in the first place.»

When this breakdown happens, the immune system responds by releasing products that cause an inflammatory reaction, activating abnormal clotting in the mother's lungs and blood vessels that can result in a serious blood - clotting disorder known as disseminated intravascular coagulation.

One of that is that your heart is strong enough to pump blood, one is that your arteries and your veins can strip and squeeze blood and then you also need enough blood and fluid within your vessels and when any of those things aren't happening to a strong enough extent which can happen especially when you first switched to a low carbohydrate diet and you're not used to that, you can get some abnormal changes in blood pressure.

Great for your immune system and liver, reishi mushrooms have been described as having «lifespan - extending properties» because they're helpful in preventing abnormal blood vessels from forming.

Figure B shows abnormal, sickled red blood cells blocking blood flow in a blood vessel.

High blood pressure refers to the abnormal elevation of the pressure exerted by blood — specifically blood in the arteries — against the walls of the blood vessels and the organs those vessels supply.

Hepatic portosystemic shunt or arteriovenous fistula: a malformation of blood vessels in the liver or an abnormal communication between the arteries and veins in the liver.

Radiographs will often show the enlargement of the heart, abnormal distension of blood vessels and fluid retention in and around the lungs.

In cats, a condition that results in abnormal blood vessel development to the liver and within the liver can seriously interfere with the organ functioIn cats, a condition that results in abnormal blood vessel development to the liver and within the liver can seriously interfere with the organ functioin abnormal blood vessel development to the liver and within the liver can seriously interfere with the organ function.

Some cancers manifest themselves in the form of a mass of abnormal cells called a tumor, while others affect cells in the blood or lymph systemA network of organs, lymph nodes, lymph ducts, and lymph vessels that make and move lymph from tissues to the bloodstream.

Patients with nephrotic syndrome have high blood pressure and may develop abnormal blood clots resulting in a variety of signs associated with occluded or blocked blood vessels, or edema (swelling), especially of the legs or abdomen.

These are big words for a very small abnormal blood vessel but, in fact, the PDA is the most common congenital heart defect of the dog.

Acquired PSS almost always presents as multiple abnormal vessels, which develop in response to an increase in blood pressure within the liver (hepatic hypertension).

The treatment is almost always a surgical procedure in which the abnormal blood vessels are removed.

A heart murmur is an abnormal sound heard on physical exam with a stethoscope, which develops when blood flow in the heart or great vessels is turbulent.

Arteriovenous Malformation (AVM) refers to an abnormal network of blood vessels in which arteries connect directly to veins instead of going through a bed of capillaries.