Not exact matches
Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in zebrafish, which resulted in
abnormal facial
cartilage, smaller eyes and structural abnormalities of neurons involved in the
development of reproductive organs.
They are used for arthritis, knee ligament injury (anterior cruciate ligament disease or ACL), canine hip dysplasia, elbow dysplasia, dislocating knee cap (patellar dislocation), rheumatoid or septic arthritis,
abnormal joint
cartilage development (osteochondritis dissecans or OCD), and spinal arthritis (spondylosis deformans).
Achondroplasia:
abnormal development of
cartilage leading to dwarfism (seen aberrantly in most breeds, but that's what makes a Basset hound and other achondroplastic breeds long and low).
Although short legs are normal for these breeds it is basically the result of
abnormal development of
cartilage.
Osteochondritis Dissecans or OCD is a serious joint disease in which
abnormal development of
cartilage occurs.
These theories include failure of transition of
cartilage to bone during
development, and excessive wear and tear on the coronoid process due to joint incongruity which places
abnormal stresses on the developing bone.
This abnormality can lead to
development of
abnormal cartilage, and eventually create a loose flap of
cartilage within the joint.
The term osteochondrosis refers to an
abnormal development of the
cartilage on the end of a bone in the joint, while osteochondritis dissecans refers to a separation of the diseased
cartilage from the underlying bone.
Abnormal development of the hip causes excessive wear of the joint
cartilage during weight bearing, eventually leading to the
development of arthritis, often called degenerative joint disease (DJD) or osteoarthritis (OA).