In 1914, German biologist Theodor Boveri postulated that
abnormal chromosome number, or aneuploidy, might be a root cause of cancer.
Errors in meiosis can result in
abnormal chromosome numbers / aneuploidy (Down Syndrome), pregnancy loss, poor oocyte quality and infertility.
Not exact matches
But it also might be
chromosome number two, and so if you have an
abnormal amount of
chromosome number two, and then the sperm comes in and meets it you either have only one or you might have three.
An embryo that carries an
abnormal number of
chromosomes is «aneuploid».
That's because D7 embryos — which develop more slowly — are thought more likely to contain an
abnormal number of
chromosomes (aneuploidy).
«One of the main causes of female infertility is a defect in the eggs that causes them to have an
abnormal number of
chromosomes.
Many tumors are characterized by «aneuploidy,» meaning they display an
abnormal number of
chromosomes and chromosomal segments.
Abnormal number of
chromosomes is often associated with cancer development.
«They have
abnormal numbers of
chromosomes, and they would develop abnormally, and so you can't use them.
The discovery might also apply to cancer, because cancer cells often have
abnormal numbers and arrangements of
chromosomes.
As with most cancers, triple - negative breast cancer (TNBC) cells have
abnormal amounts of
chromosomes or DNA copy
number aberrations (CNAs) in their genomes.
Li points out that, unlike yeast cells, human and mammalian cells have a protein called p53 that kills cells with
abnormal numbers of
chromosomes.
Aneuploidy is a condition in which cells contain an
abnormal number of
chromosomes, and is known to be the cause of many types of cancer and genetic disorders, including Down Syndrome.
UroSEEK uses urine samples to seek out mutations in 11 genes or the presence of
abnormal numbers of
chromosomes that would indicate the presence of DNA associated with bladder cancer or upper tract urothelial cancer (UTUC).
For more than 100 years, researchers have been unable to explain why cancer cells contain
abnormal numbers of
chromosomes, a phenomenon known as aneuploidy.
Aneuploidy (an
abnormal number of
chromosomes) is the most common genetic alteration in human tumors and a major cause for birth defects (Figure 4).
His focus shifted to the
abnormal number of
chromosomes that virtually every cancer tumor has — an observation first made by German scientist Theodor Boveri in the early 20th century.
A genetic test examines a DNA sample of a person's cells for
abnormal genes, or analyzes the
number, arrangement and characteristics of the
chromosomes.
Moreover, many human tumors have highly
abnormal numbers of
chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??
If the test result is
abnormal (the tissue has an
abnormal number of
chromosomes), its good news.