Sentences with phrase «abnormal expression»

Noting that high estrogen concentrations are «a defining characteristic of dominant follicles,» Dr. Denis Magoffin (Ceders - Sinai Medical Center, Los Angeles, California, USA) and co-investigators examined whether abnormal expression of ERs could contribute to poor follicular development and ovulatory failure in women with PCOS.

Using RNA sequencing, the researchers found multiple genes whose abnormal expression could lead to the high rate of death for cloned embryos, including failure to implant in the uterus and failure to develop a normal placenta.

Using a combination of techniques, they found abnormal expression of more than a half - dozen myelin - related genes in the mental patients.

Her team has discovered that mutations or abnormal expression in the gene that encodes ASM can result in a wide range of impacts, from regulating lifespan to enhancing the risk of cancer and neuron degenerative disease.

In a paper published recently in the Journal of Clinical Investigation, lead authors at the University of Georgia, along with colleagues from the Rensselaer and the University of California at San Diego, demonstrated for the first time that the gene NDST1 plays a significant role in the proper development of the diaphragm, and that abnormal expression of the gene could lead to CDH.

For their study, HSS researchers hypothesized that the abnormal expression of genetic elements known as LINE - 1 (L1) retroelements might trigger an innate immune response similar to that produced by outside viruses and contribute to an overproduction of interferons.

The change in the environment — the tumor and its surroundings — causes the abnormal expression of these proteins.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

In fact, a recent study by Arakawa and colleagues of thyroid patients with Hashimoto's and Graves» found that polymorphisms — that is, gene variations that may lead to the abnormal expressions — were as common in autoimmune thyroid disease as they were in the normal population.