Sentences with phrase «abnormal expression in»

Her team has discovered that mutations or abnormal expression in the gene that encodes ASM can result in a wide range of impacts, from regulating lifespan to enhancing the risk of cancer and neuron degenerative disease.

Not exact matches

Intriguingly, DNA in many of the placenta samples has the same imprinting abnormality seen in Silver - Russell, but a dampened down version of it — perhaps a smaller stretch of the gene is affected, or gene expression is less abnormal.

Using RNA sequencing, the researchers found multiple genes whose abnormal expression could lead to the high rate of death for cloned embryos, including failure to implant in the uterus and failure to develop a normal placenta.

Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in zebrafish, which resulted in abnormal facial cartilage, smaller eyes and structural abnormalities of neurons involved in the development of reproductive organs.

In a paper published recently in the Journal of Clinical Investigation, lead authors at the University of Georgia, along with colleagues from the Rensselaer and the University of California at San Diego, demonstrated for the first time that the gene NDST1 plays a significant role in the proper development of the diaphragm, and that abnormal expression of the gene could lead to CDIn a paper published recently in the Journal of Clinical Investigation, lead authors at the University of Georgia, along with colleagues from the Rensselaer and the University of California at San Diego, demonstrated for the first time that the gene NDST1 plays a significant role in the proper development of the diaphragm, and that abnormal expression of the gene could lead to CDin the Journal of Clinical Investigation, lead authors at the University of Georgia, along with colleagues from the Rensselaer and the University of California at San Diego, demonstrated for the first time that the gene NDST1 plays a significant role in the proper development of the diaphragm, and that abnormal expression of the gene could lead to CDin the proper development of the diaphragm, and that abnormal expression of the gene could lead to CDH.

The involvement of this enzyme in susceptibility to oxidative stress, which has frequently been observed in autistic children, its association with gastrointestinal diseases — which often accompany autistic disorders — and its role in nerve development and neurotransmission mean it is an ideal candidate for deregulation of its expression to lead to the abnormal brain development observed in ASD.

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

The change in the environment — the tumor and its surroundings — causes the abnormal expression of these proteins.

Using a combination of techniques, they found abnormal expression of more than a half - dozen myelin - related genes in the mental patients.

Thomas Look and colleagues use a type of genomic screen and identify abnormal HGF expression as a crucial factor for development of a class of acute leukemia in leukemia cell lines and clinical samples.

The finding wasn't surprising, Fallin explains — numerous studies have identified abnormal gene expression of immune genes in autism samples and environmental experiences such as prenatal infection or prenatal exposure to pollutants that can ramp up immune responses are risk factors for ASD.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

In diabetic rat models, female mesenteric arteries show greater abnormal vascular responses demonstrated by greater impairment of acetycholin - induced relaxation and an increased expression of endothelial nitric oxide synthase.

For practical purposes, both mutations and epimutations ultimately harm us in the same way: by causing abnormal gene expression.

However, we can not suspect any abnormal effect on parthenotes due to the aberrant expression of CCNA1 since the protein is not expressed at the blastocyst stage [33], and its cell cycle regulation role is limited in meiotic cells [34].

A University of Tokyo research group has discovered that genome - wide epigenetic disorder is behind patterns of abnormal gene expression found in adult T - cell leukemia - lymphoma...

Since insulin - like peptides are major growth hormones in flies, we anticipated that abnormal expression and secretion of Dilps in the CCHa2 - R mutants would lead to growth defects.

We report here that in vitro generated DS neural cells have abnormal metabolism of amyloid - β (Aβ) manifested by increased secretion and accumulation of Aβ granules of Aβ42 pathological isoform with upregulated expression of the APP gene.

On the other hand, the SCP1 expression is detected in germ cells of SCP3 KO mice, though the structure of the synaptonemal complex and localization of SCP1 in the complex are abnormal in comparison to the wild - type germ cells [50].

Uhlhaas and colleagues summarize decades of work to hypothesize that «in ASDs abnormal brain maturation during early prenatal and postnatal periods results in cortical circuits that are unable to support the expression of high - frequency oscillations during infancy.

Suboptimal IVC reduced the expression of Kap1, Sox2, Hdac1, Dnmt1, and Dnmt3a, suggesting a molecular epigenetic role for gene expression modifiers in the origin and transmission of these abnormal phenotypes.

It is possible that the Oct4 expression patterns that we observe is due to failure of one or more of these processes in the complex, abnormal milieu of this embryonal carcinoma cell line during differentiation.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

Noting that high estrogen concentrations are «a defining characteristic of dominant follicles,» Dr. Denis Magoffin (Ceders - Sinai Medical Center, Los Angeles, California, USA) and co-investigators examined whether abnormal expression of ERs could contribute to poor follicular development and ovulatory failure in women with PCOS.

«The results of this study demonstrate that there are significant alterations in the expression of ER - alpha and ER - beta in PCOS that may be related to abnormal follicular development,» Magoffin et al conclude.

In fact, a recent study by Arakawa and colleagues of thyroid patients with Hashimoto's and Graves» found that polymorphisms — that is, gene variations that may lead to the abnormal expressions — were as common in autoimmune thyroid disease as they were in the normal populatioIn fact, a recent study by Arakawa and colleagues of thyroid patients with Hashimoto's and Graves» found that polymorphisms — that is, gene variations that may lead to the abnormal expressions — were as common in autoimmune thyroid disease as they were in the normal populatioin autoimmune thyroid disease as they were in the normal populatioin the normal population.

Their external expression is a reflection of their body's tendency to be more sluggish and less effective in eliminating toxins, correcting imbalances and removing abnormal cancerous cells.

AASECT opposes the application of labels such as «normal» and «abnormal» to these variations in the healthy sexual expression of adults, and AASECT believes that all sexual and cultural minorities should enjoy sexual freedom, equal civil rights, and parity of social opportunities and privileges.

Yet if the «exclusion demand» was an expression of the child's independence and 100 % of children need to address this issue, then we would expect to see millions of children expressing the «exclusion demand» but instead the rate of the «exclusion demand» in the normal (and abnormal) range population is 0 %.

[jounal] Blair, R. / 2001 / A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendencies / Journal of Abnormal Child Psychology 29: 491 ~ 498

[jounal] Blair, R. J. R. / 2001 / A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendencies / Jounal of Abnormal Child Psychology 29: 491 ~ 498