Noting that high estrogen concentrations are «a defining characteristic of dominant follicles,» Dr. Denis Magoffin (Ceders - Sinai Medical Center, Los Angeles, California, USA) and co-investigators examined whether
abnormal expression of ERs could contribute to poor follicular development and ovulatory failure in women with PCOS.
Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers
an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).
Using a combination of techniques, they found
abnormal expression of more than a half - dozen myelin - related genes in the mental patients.
The change in the environment — the tumor and its surroundings — causes
the abnormal expression of these proteins.
In a paper published recently in the Journal of Clinical Investigation, lead authors at the University of Georgia, along with colleagues from the Rensselaer and the University of California at San Diego, demonstrated for the first time that the gene NDST1 plays a significant role in the proper development of the diaphragm, and that
abnormal expression of the gene could lead to CDH.
Not exact matches
Intriguingly, DNA in many
of the placenta samples has the same imprinting abnormality seen in Silver - Russell, but a dampened down version
of it — perhaps a smaller stretch
of the gene is affected, or gene
expression is less
abnormal.
Using RNA sequencing, the researchers found multiple genes whose
abnormal expression could lead to the high rate
of death for cloned embryos, including failure to implant in the uterus and failure to develop a normal placenta.
Investigators at Duke University, led by Erica Davis, PhD, a co-senior author
of the report, blocked the gene's
expression in zebrafish, which resulted in
abnormal facial cartilage, smaller eyes and structural abnormalities
of neurons involved in the development
of reproductive organs.
FA is caused by reduced
expression of a mitochondrial protein called frataxin (FXN) due to a two mutated or
abnormal copies
of the FXN gene.
Of particular interest are the emerging techniques for genomics and proteomics, which allow profiles of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemical
Of particular interest are the emerging techniques for genomics and proteomics, which allow profiles
of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemical
of gene
expression and protein synthesis to be produced and comparisons to be made between normal and
abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicals.
The involvement
of this enzyme in susceptibility to oxidative stress, which has frequently been observed in autistic children, its association with gastrointestinal diseases — which often accompany autistic disorders — and its role in nerve development and neurotransmission mean it is an ideal candidate for deregulation
of its
expression to lead to the
abnormal brain development observed in ASD.
«Our present study shows examination
of the gene
expression profiles at the very early age
of initial clinical detection reveals both strong evidence
of early biological processes in ASD and
abnormal signals with the potential to serve as an early, practical biomarker
of risk for the disorder in general pediatric settings.»
Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup
of an
abnormal version
of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene
expression.
Thomas Look and colleagues use a type
of genomic screen and identify
abnormal HGF
expression as a crucial factor for development
of a class
of acute leukemia in leukemia cell lines and clinical samples.
The finding wasn't surprising, Fallin explains — numerous studies have identified
abnormal gene
expression of immune genes in autism samples and environmental experiences such as prenatal infection or prenatal exposure to pollutants that can ramp up immune responses are risk factors for ASD.
However, this cellular intervention alters the normal
expression of hypophosphorylated retinoblastoma (RB) protein needed for the
expression of genes involved in cell functions [3] and, therefore, results in an
abnormal cell.
«The authors went on to study the resulting blastocysts for aneuploidy (frequency
of abnormal chromosomes), and pattern
of gene
expression (which genes are active and at what level).
In diabetic rat models, female mesenteric arteries show greater
abnormal vascular responses demonstrated by greater impairment
of acetycholin - induced relaxation and an increased
expression of endothelial nitric oxide synthase.
During the multistep process
of carcinogenesis, decreased
expression of tumor suppressors is often caused by epigenetic modification or
abnormal degradation (48, 49).
However, we can not suspect any
abnormal effect on parthenotes due to the aberrant
expression of CCNA1 since the protein is not expressed at the blastocyst stage [33], and its cell cycle regulation role is limited in meiotic cells [34].
A University
of Tokyo research group has discovered that genome - wide epigenetic disorder is behind patterns
of abnormal gene
expression found in adult T - cell leukemia - lymphoma...
Since insulin - like peptides are major growth hormones in flies, we anticipated that
abnormal expression and secretion
of Dilps in the CCHa2 - R mutants would lead to growth defects.
Her team has discovered that mutations or
abnormal expression in the gene that encodes ASM can result in a wide range
of impacts, from regulating lifespan to enhancing the risk
of cancer and neuron degenerative disease.
We report here that in vitro generated DS neural cells have
abnormal metabolism
of amyloid - β (Aβ) manifested by increased secretion and accumulation
of Aβ granules
of Aβ42 pathological isoform with upregulated
expression of the APP gene.
On the other hand, the SCP1
expression is detected in germ cells
of SCP3 KO mice, though the structure
of the synaptonemal complex and localization
of SCP1 in the complex are
abnormal in comparison to the wild - type germ cells [50].
Uhlhaas and colleagues summarize decades
of work to hypothesize that «in ASDs
abnormal brain maturation during early prenatal and postnatal periods results in cortical circuits that are unable to support the
expression of high - frequency oscillations during infancy.
Molecular profiling
of large tumour numbers has also allowed the annotation
of more than 13 million non-coding mutations, 18 029 gene fusions, 187 429 genome rearrangements, 1 271 436
abnormal copy number segments, 9 175 462
abnormal expression variants and 7 879 142 differentially methylated CpG dinucleotides.
Suboptimal IVC reduced the
expression of Kap1, Sox2, Hdac1, Dnmt1, and Dnmt3a, suggesting a molecular epigenetic role for gene
expression modifiers in the origin and transmission
of these
abnormal phenotypes.
It is possible that the Oct4
expression patterns that we observe is due to failure
of one or more
of these processes in the complex,
abnormal milieu
of this embryonal carcinoma cell line during differentiation.
«The results
of this study demonstrate that there are significant alterations in the
expression of ER - alpha and ER - beta in PCOS that may be related to
abnormal follicular development,» Magoffin et al conclude.
In fact, a recent study by Arakawa and colleagues
of thyroid patients with Hashimoto's and Graves» found that polymorphisms — that is, gene variations that may lead to the
abnormal expressions — were as common in autoimmune thyroid disease as they were in the normal population.
No genes that produce
abnormal proteins were found, but instead the elevated risk appears to come from groups
of tightly - linked DNA sequences called «haplotypes» that regulate the
expression of protein - coding genes.
Their external
expression is a reflection
of their body's tendency to be more sluggish and less effective in eliminating toxins, correcting imbalances and removing
abnormal cancerous cells.
AASECT opposes the application
of labels such as «normal» and «
abnormal» to these variations in the healthy sexual
expression of adults, and AASECT believes that all sexual and cultural minorities should enjoy sexual freedom, equal civil rights, and parity
of social opportunities and privileges.
Yet if the «exclusion demand» was an
expression of the child's independence and 100 %
of children need to address this issue, then we would expect to see millions
of children expressing the «exclusion demand» but instead the rate
of the «exclusion demand» in the normal (and
abnormal) range population is 0 %.
[jounal] Blair, R. / 2001 / A selective impairment in the processing
of sad and fearful
expressions in children with psychopathic tendencies / Journal
of Abnormal Child Psychology 29: 491 ~ 498
[jounal] Blair, R. J. R. / 2001 / A selective impairment in the processing
of sad and fearful
expressions in children with psychopathic tendencies / Jounal
of Abnormal Child Psychology 29: 491 ~ 498