Sentences with phrase «abnormal form»

There, Red Eagle studied the toxicity and stability of abnormal forms of a protein called transthyretin, which can cause heart failure and neurodegenerative disorders.

Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.

However, cancer cells often generate abnormal forms of the androgen receptor that can be switched on all the time without the need for androgen hormone stimulation.

«If we can establish a link between abnormal forms of this gene and ADHD, it could provide us with a powerful new tool for precise diagnosis and early identification of children at risk, and a signpost toward designing better drug treatment,» said Ed Cook, associate professor of psychiatry and of pediatrics at the University of Chicago and lead author of the report.

The new research found that on top of their known effects on cancer, Hsp90 inhibition also blocked production of abnormal forms of the androgen receptor, stripping cancer cells of their defences against hormone treatments.

Meanwhile Kazuo Kuwata and colleagues at Gifu University in Japan have developed a molecule called GN8 that has potential to prevent vCJD by binding to the normal prion protein and preventing it misfolding into the abnormal form that causes disease.

That discovery raised the question of whether the abnormal form of PrP alone can force molecules of the normal form to change shape, spreading destruction in the brain.

For nearly 30 years, researchers have gathered evidence that a group of bizarre, fatal brain diseases — including mad cow and its human equivalent, Creutzfeldt - Jakob disease — are caused not by a virus or bacterium but by an abnormal form of a protein, called a prion.

This particular liver cancer arises from a mutation that produces an abnormal form of the enzyme that is the topic of this current work, protein kinase A, and alters the enzyme's role in cell signaling.

Clinical and experimental evidence suggests however that alpha - synuclein — or abnormal forms of it — could «jump» from one neuron to another and thus spread between anatomically interconnected regions.

The researchers engineered frog eggs to express the 17 abnormal forms of KCNQ1, then measured how the cells transmitted electrical currents.

One provocative theory is that the disease crossed from the patient's own brain tissue, perhaps by an abnormal form of the α - synuclein protein in a process similar to that caused by the «prion» proteins implicated in mad cow disease.

Deferiprone, available for the past 20 years, is used in more than 60 countries to prevent death from blood transfusion - related complications during treatment of thalassemia, an inherited blood disorder in which the body makes an abnormal form of hemoglobin.

The RTM hypothesis is that the immune systems of people who reach the ages at which AS, beta - amyloid, and other pathological aggregates begin to accumulate would generate antibodies against their abnormal form, and that people who remain free of these specific diseases might be producing antibodies that are particularly effective at keeping these aggregates at bay.

Huntingtin is useful, but in HD, an abnormal form of the protein called mutant huntingtin causes damage, kills neurons and eventually produces the symptoms of the disease.