Sentences with phrase «abnormal functioning in»

The new study, published today in the journal PLoS Genetics, identifies abnormal functioning in a gene called PKP2 that encodes the plakophilin - 2 protein, which promotes and maintains a healthy skin barrier.

Some research indicates that a percentage of babies who die of SIDS may have abnormal functioning in the part of the brain that controls waking up from sleep.

Detecting protein - protein interactions is key to understanding both normal and abnormal functions in the cell.

Abnormal function in the dlPFC might be connected to the lethargy associated with both conditions.

Not exact matches

Prior to bone injury, symptoms can be vague and nonspecific such as decreased energy, strength, endurance and cold intolerance; however, abnormal menstrual function should raise concerns in these athletes.

The results showed the former players experienced a reduction in fine motor control and abnormal changes in brain function when compared with healthy people of the same age who had never played contact sport.

The study also discovered that microscopic spasms in capillaries occur, albeit with lower frequency, during normal brain function, too, suggesting that one problem caused by epilepsy is that seizures drive these vasospasms to abnormal levels.

In Cooper's lab, Godinho Ferreira worked to understand why telomeres function differently than deleterious chromosome ends generated by the abnormal breaking of chromosomes.

Payne keyed in the symptoms, and the computer program suggested a handful of potential conditions, including a rare disease called amyloidosis, in which abnormal proteins build up in the body, interfering with normal organ function and causing nerve damage.

The TOPCAT trial also presented the opportunity to study cardiac structure and function in this population through an echocardiography sub-study in 935 patients, which demonstrated a high prevalence of abnormal cardiac structure in these patients.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically engineered mice such that the scientists could switch the TET2 gene on or off.

This sensation of pain was previously thought to be caused by abnormal plasticity in the sensorimotor cortex of the brain, and rehabilitative therapies have focused on restoring normal motor function to relieve the pain.

Abnormal brain activity in psychotic disorders, such as schizophrenia and bipolar disorder, is thought to stem in part from impaired function of the NMDA receptor.

Earlier research by other scientists has shown that the drug verteporfin, used to treat abnormal blood vessel formation in the eye, acts on the YAP pathway inhibiting the protein's YAP function.

Damage to the BSCB, explained the researchers, plays a fundamental role in the development of several pathological conditions, including abnormal motor function.

While late - term gestation was associated with an increase in the rate of abnormal conditions at birth and with worse physical outcomes during childhood, it was also associated with better performance on all three measures of school - based cognitive functioning measures during childhood,» the study concludes.

The other five were conducted in mice; they found that, after being exposed to the blood of young mice, old mice had less abnormal thickening of their heart, grew more nervous tissue, and saw improved cognitive function, among other changes.

More than 2.5 million Americans have epilepsy, a disorder in which abnormal electrical impulses in the brain affect a variety of mental and physical functions.

The introduction of ICSI in 1992 revolutionized the treatment of couples with male factor infertility (infertility due to abnormal semen characteristics, abnormal sperm function, or surgical sterilization), and made paternity possible for a large proportion of men with no measurable sperm count.

The mice had symptoms such as abnormal brain function, impaired memory and high levels of either amyloid - beta or tau proteins in the brain.

The child is still breathing, the child is walking, the locomotor function is not so abnormal that it's incompatible with life in our culture.

And in some of the most dramatic evidence of the technique's potential, a research team reports this week in Science Translational Medicine that they used it to rid mice of abnormal brain clumps similar to those in Alzheimer's disease, restoring lost memory and cognitive functions.

Abnormal chandelier cell function also has been implicated in schizophrenia.

Abnormal CaSR function can not only trigger familial benign hypercalcaemia and hyperparathyroidism but it is also involved in various other diseases such as Alzheimer's disease, diabetes, cancer and cardiovascular diseases.

Research findings indicate that abnormal CaSR function and / or abundance play a significant role in the development or progression of several non-communicable diseases (or NCDs) such as Alzheimer's disease, cardiovascular diseases, diabetes, cancer, and degenerative muscle loss.

Abnormal functioning of the amygdala is implicated in several neurological diseases, such as autism, phobias, post-traumatic stress disorder and anxiety.

Researchers still don't fully understand how this cholesterol - processing dysfunction leads to the suite of symptoms seen in NPC patients, including abnormal motor function and loss of cognitive function.

Besides the redundant scalp and abnormal cranial shapes resulting from the arrest in brain growth, other physical features consistent with ZIKV infection reflect immobility of the joints, resulting from altered brain function in utero.

The abnormal spinal curvature causes a wide range of problems, including inability to balance in a seated position, pain, and possibly long - term adverse effects on lung, heart, and gastrointestinal function.

Brain - imaging studies confirmed that hippocampal function was abnormal in people with the methionine variant.

Combining morphine, a narcotic pain reliever, and nortriptyline, an antidepressant, has been found to successfully relieve chronic neuropathic pain — or a localized sensation of pain due to abnormal function of the nervous system — in 87 per cent of patients, and significantly better than with either drug alone.

The most common genetic mutation in ALS and FTD is an abnormal repeated expansion of the coding sequence within a gene, C9ORF72, with unknown function.

The attenuation of MP's effects could also reflect abnormal D2 receptor function, as was previously suggested to explain findings in marijuana - abusing schizophrenic patients, who, despite displaying low DA release, showed increases in psychotic symptoms when challenged with amphetamine (21).

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

However, using these cell lines it should be possible to determine in detail how the defects arise (which is difficult in patients), and perhaps how to alter the segregation of mutant versus normal mtDNA during cell division to eventually lessen the burden of abnormal mitochondria function.

This led the researchers to conclude that the abnormal functioning of the astroglial cells plays a key role in the occurrence of Down syndrome.

In the study, they show how levetiracetam — a drug commonly prescribed for patients who suffer from epilepsy — suppresses abnormal brain activity and restores memory function in these micIn the study, they show how levetiracetam — a drug commonly prescribed for patients who suffer from epilepsy — suppresses abnormal brain activity and restores memory function in these micin these mice.

The Center for Integrative and Cognitive Neuroscience, directed by Jeffrey Schall, helps form and support alliances of investigators interested in studying how normal and abnormal behavior and cognition arise from the function of the brain.

To achieve this goal, the center's clinical and basic investigators are engaging in four distinct yet synergistic projects: 1) identifying mechanisms of abnormal cell proliferation, 2) examining the role of thrombosis in the development of PAH, 3) studying the role of nitric oxide deficiency in PAH, and 4) testing two existing drugs to restore lost cellular function due to a genetic mutation related to PAH.

Patient 2: NBAS c. 5741G > A p. (Arg1914His); c. 2032C > T p. (Gln678 *) in a 5 - year old boy with similar presenting features, bone fragility, mild developmental delay, abnormal liver function tests and immunodeficiency.

The Institute is studying the functional architecture of the prefrontal cortex and the role this crucial circuitry plays in both normal and abnormal cognitive function.

«The [theory] that has guided therapeutic strategies for more than 30 years is that amyloid beta is a freak, that what it does is abnormal and has no function,» says study corresponding author Robert Moir, PhD, of the Genetics and Aging Research Unit at the MassGeneral Institute for Neurodegenerative Disease in Boston.

About 40 percent of Americans have calcified pineals by age seventeen.50 «Calcium, phosphorus and fluoride deposits increase with aging and are likely to cause decreased melatonin production and abnormal pineal function, which could contribute to a variety of effects in humans.»

If we skimp on this vital form of self - care we not only set ourselves up for poor mental function the next day but we're also more prone to abnormal fluctuations in cortisol and weight gain.

During the pregnancy period, whether a person is normal, slightly abnormal, or borderline, many women have a borderline OAT axis imbalance and a borderline estrogen dominance, and so it's very important to pay some attention to supporting the body's adrenal function and to normalizing the estrogen level during the pregnancy period in order to have a smooth second and third trimester and a smooth delivery.

The resulting nerve interference disrupts the flow of information between your brain and the regions of your body supplied by the irritated spinal nerves, potentially resulting in loss of function or abnormal function of affected cells, tissues, organs, and organ systems.

These free radicals are generated in the body due to abnormal metabolism or improper physiological function and they start damaging cells responsible for maintaining immunity of the body, thus lowering the immunity level and making the body prone to infections.

Autoimmune diseases can result in the destruction of body tissue (s), abnormal growth of an organ or changes in organ function.

Newborns also receive Thyroid tests to determine if their thyroid function is normal in order to avoid growth and developmental issues which may result from abnormal levels of the hormone.

A. Folate / folic acid (B9)- Mouth sores and pale skin B. Inositol - Poor brain function, hair loss, high LDL, and eczema C. Vitamin A-Dry eyes, dry skin, bright lights at night bothersome, trouble distinguishing between blues and purples D. Vitamin B1 (Thiamine)- Loss of appetite, pain in limbs swollen feet or legs E. Vitamin B2 (Riboflavin)- Anemia, nerve damage, sluggish metabolism, sore throat F. Vitamin C - Bruising, bleeding gums, fatigue, loss of appetite G. Vitamin D - Thin or brittle bones, joint pain, fatigue, depression, getting sick often, impaired wound healing H. Vitamin E-Muscle weakness, Abnormal eye movements, vision problems I. Vitamin K2 - Easy bruising, excessive bleeding from wounds, blood in urine or stool