Sentences with phrase «abnormal functioning of»

Abnormal functioning of neurotransmitter systems has been implicated, including serotonin, norepinephrine, dopamine and glutamate systems.

Depression, inflammation, and the clustering of metabolic risk markers indicate abnormal functioning of stress - sensitive systems.9 These 3 conditions also predict age - related diseases.

«The investigation of a dog hip problem usually involves tests for a genetic condition called hip dysplasia (CHD), which is the abnormal functioning of the hips, and osteoarthritis.

This led the researchers to conclude that the abnormal functioning of the astroglial cells plays a key role in the occurrence of Down syndrome.

«While it is well - established that obesity generates cellular and molecular stress leading to abnormal functioning of many cellular processes, the mechanisms remain incompletely understood,» said senior author Gökhan S. Hotamisligil, chair of the Department of Genetics and Complex Diseases and the Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research.

Abnormal functioning of the amygdala is implicated in several neurological diseases, such as autism, phobias, post-traumatic stress disorder and anxiety.

Seeing your life pass before you and the light at the end of the tunnel, can be explained by new research on abnormal functioning of dopamine and oxygen flow

Combining morphine, a narcotic pain reliever, and nortriptyline, an antidepressant, has been found to successfully relieve chronic neuropathic pain — or a localized sensation of pain due to abnormal function of the nervous system — in 87 per cent of patients, and significantly better than with either drug alone.

The resulting nerve interference disrupts the flow of information between your brain and the regions of your body supplied by the irritated spinal nerves, potentially resulting in loss of function or abnormal function of affected cells, tissues, organs, and organ systems.

The close relationship between liver and pancreas with the upper gut can lead to a triad of abnormalities whereby the pancreas becomes inflamed, as does the liver, and the abnormal function of these organs leads to inflammation and a change in the normal digestive system balance in the small intestine.

Not exact matches

But when I looked up Xylitol this is what I found; The side effects of xylitol, a low - calorie sweetener and alternative to sugar, include gas, diarrhea, low blood sugar and possible abnormal liver function tests.

Some research indicates that a percentage of babies who die of SIDS may have abnormal functioning in the part of the brain that controls waking up from sleep.

The results showed the former players experienced a reduction in fine motor control and abnormal changes in brain function when compared with healthy people of the same age who had never played contact sport.

In Cooper's lab, Godinho Ferreira worked to understand why telomeres function differently than deleterious chromosome ends generated by the abnormal breaking of chromosomes.

The origins of the major types of headaches remain a conundrum: Headaches seem to result from the abnormal brain functions of a completely normal brain structure.

Payne keyed in the symptoms, and the computer program suggested a handful of potential conditions, including a rare disease called amyloidosis, in which abnormal proteins build up in the body, interfering with normal organ function and causing nerve damage.

PSC is otherwise difficult to detect, with half of affected individuals not having symptoms until they receive abnormal results from liver function tests.

The TOPCAT trial also presented the opportunity to study cardiac structure and function in this population through an echocardiography sub-study in 935 patients, which demonstrated a high prevalence of abnormal cardiac structure in these patients.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically engineered mice such that the scientists could switch the TET2 gene on or off.

A research group discovered a new function of the chromosomal terminus, which may lead to the clarification of the mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation.

This sensation of pain was previously thought to be caused by abnormal plasticity in the sensorimotor cortex of the brain, and rehabilitative therapies have focused on restoring normal motor function to relieve the pain.

Besides, the function of subtelomere, the telomere - adjacent region, has not yet been clarified although abnormal telomere structure such as multiple malformation and mental retardation exists.

Abnormal brain activity in psychotic disorders, such as schizophrenia and bipolar disorder, is thought to stem in part from impaired function of the NMDA receptor.

The device can treat either form of age - related macular degeneration: the dry stage, where the delicate tissues of the macula become thinned and slowly lose function, or the less common wet stage that's caused by the growth of abnormal blood vessels behind the macula.

«Too little of this protein disrupts normal stem cell function, but too much can promote abnormal growth and lead to cancer.

Damage to the BSCB, explained the researchers, plays a fundamental role in the development of several pathological conditions, including abnormal motor function.

While late - term gestation was associated with an increase in the rate of abnormal conditions at birth and with worse physical outcomes during childhood, it was also associated with better performance on all three measures of school - based cognitive functioning measures during childhood,» the study concludes.

The other five were conducted in mice; they found that, after being exposed to the blood of young mice, old mice had less abnormal thickening of their heart, grew more nervous tissue, and saw improved cognitive function, among other changes.

More than 2.5 million Americans have epilepsy, a disorder in which abnormal electrical impulses in the brain affect a variety of mental and physical functions.

The introduction of ICSI in 1992 revolutionized the treatment of couples with male factor infertility (infertility due to abnormal semen characteristics, abnormal sperm function, or surgical sterilization), and made paternity possible for a large proportion of men with no measurable sperm count.

The mice had symptoms such as abnormal brain function, impaired memory and high levels of either amyloid - beta or tau proteins in the brain.

And in some of the most dramatic evidence of the technique's potential, a research team reports this week in Science Translational Medicine that they used it to rid mice of abnormal brain clumps similar to those in Alzheimer's disease, restoring lost memory and cognitive functions.

The group» finding that the impaired intracellular protein trafficking leads to neuropsychiatric disorders - related abnormal higher brain functions has high impact on the fields of psychiatry, basic medical sciences, and pharmaceutical sciences.

Research findings indicate that abnormal CaSR function and / or abundance play a significant role in the development or progression of several non-communicable diseases (or NCDs) such as Alzheimer's disease, cardiovascular diseases, diabetes, cancer, and degenerative muscle loss.

These splice sites instruct the genetic machinery to build abnormal dystrophin molecules, but once the gene is successfully edited it expresses a much - improved dystrophin protein product, enhancing the function of the muscle tissue.

Researchers still don't fully understand how this cholesterol - processing dysfunction leads to the suite of symptoms seen in NPC patients, including abnormal motor function and loss of cognitive function.

The abnormal brain circuitry of LKS patients renders the brain incapable of imprinting memory, further impairing brain function.

Molofsky is a psychiatrist who studies how astrocytes organize nerve circuits, and how disruptions of these nerve circuits during development or disease may involve abnormal astrocyte function.

Besides the redundant scalp and abnormal cranial shapes resulting from the arrest in brain growth, other physical features consistent with ZIKV infection reflect immobility of the joints, resulting from altered brain function in utero.

Until now, U.S. safety regulations have been based on ensuring plants are designed to withstand certain specified failures or abnormal events, or «design - basis - events» — such as equipment failures, loss of power, and inability to cool the reactor core — that could impair critical safety functions.

The abnormal spinal curvature causes a wide range of problems, including inability to balance in a seated position, pain, and possibly long - term adverse effects on lung, heart, and gastrointestinal function.

Biology may also play a role — for example, a greater propensity towards abnormal blood vessel function during emotional stress, such as exaggerated constriction of coronary or peripheral blood vessels.

Like Lewis, Gottmundsdottir administers simple reflex tests to check her subjects for signs of abnormal brain function.

The most common genetic mutation in ALS and FTD is an abnormal repeated expansion of the coding sequence within a gene, C9ORF72, with unknown function.

The attenuation of MP's effects could also reflect abnormal D2 receptor function, as was previously suggested to explain findings in marijuana - abusing schizophrenic patients, who, despite displaying low DA release, showed increases in psychotic symptoms when challenged with amphetamine (21).

It has been suggested that these abnormal connections cause the decrement of cognitive function.

«We still do not understand fully how these abnormal amyloid and tau protein depositions affect brain functions and cause dementia,» stated Satoshi Minoshima, MD, PhD, chair of the SNMMI Scientific Program Committee.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

• Keeping abnormal proteins from building up and potentially shutting down major organs (heart, liver and nervous system, to name a few) • Protecting the brain's functions of learning and memory against neurotransmitter toxicity • Activating or increasing the activity of proteins that promote the initial growth, maintenance and survival of brain neurons • Enhancing the movement of proteins, lipids and other cell parts through the cytoplasm of cell bodies.

However, using these cell lines it should be possible to determine in detail how the defects arise (which is difficult in patients), and perhaps how to alter the segregation of mutant versus normal mtDNA during cell division to eventually lessen the burden of abnormal mitochondria function.